NFED1_BACSU
ID NFED1_BACSU Reviewed; 437 AA.
AC P54465;
DT 01-OCT-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1996, sequence version 1.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Membrane protein NfeD1b {ECO:0000303|PubMed:22753055};
GN Name=nfeD1 {ECO:0000303|PubMed:22753055}; Synonyms=yqeZ;
GN OrderedLocusNames=BSU25390;
OS Bacillus subtilis (strain 168).
OC Bacteria; Firmicutes; Bacilli; Bacillales; Bacillaceae; Bacillus.
OX NCBI_TaxID=224308;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=168 / JH642;
RX PubMed=8969508; DOI=10.1099/13500872-142-11-3103;
RA Mizuno M., Masuda S., Takemaru K., Hosono S., Sato T., Takeuchi M.,
RA Kobayashi Y.;
RT "Systematic sequencing of the 283 kb 210 degrees-232 degrees region of the
RT Bacillus subtilis genome containing the skin element and many sporulation
RT genes.";
RL Microbiology 142:3103-3111(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=168;
RX PubMed=9384377; DOI=10.1038/36786;
RA Kunst F., Ogasawara N., Moszer I., Albertini A.M., Alloni G., Azevedo V.,
RA Bertero M.G., Bessieres P., Bolotin A., Borchert S., Borriss R.,
RA Boursier L., Brans A., Braun M., Brignell S.C., Bron S., Brouillet S.,
RA Bruschi C.V., Caldwell B., Capuano V., Carter N.M., Choi S.-K.,
RA Codani J.-J., Connerton I.F., Cummings N.J., Daniel R.A., Denizot F.,
RA Devine K.M., Duesterhoeft A., Ehrlich S.D., Emmerson P.T., Entian K.-D.,
RA Errington J., Fabret C., Ferrari E., Foulger D., Fritz C., Fujita M.,
RA Fujita Y., Fuma S., Galizzi A., Galleron N., Ghim S.-Y., Glaser P.,
RA Goffeau A., Golightly E.J., Grandi G., Guiseppi G., Guy B.J., Haga K.,
RA Haiech J., Harwood C.R., Henaut A., Hilbert H., Holsappel S., Hosono S.,
RA Hullo M.-F., Itaya M., Jones L.-M., Joris B., Karamata D., Kasahara Y.,
RA Klaerr-Blanchard M., Klein C., Kobayashi Y., Koetter P., Koningstein G.,
RA Krogh S., Kumano M., Kurita K., Lapidus A., Lardinois S., Lauber J.,
RA Lazarevic V., Lee S.-M., Levine A., Liu H., Masuda S., Mauel C.,
RA Medigue C., Medina N., Mellado R.P., Mizuno M., Moestl D., Nakai S.,
RA Noback M., Noone D., O'Reilly M., Ogawa K., Ogiwara A., Oudega B.,
RA Park S.-H., Parro V., Pohl T.M., Portetelle D., Porwollik S.,
RA Prescott A.M., Presecan E., Pujic P., Purnelle B., Rapoport G., Rey M.,
RA Reynolds S., Rieger M., Rivolta C., Rocha E., Roche B., Rose M., Sadaie Y.,
RA Sato T., Scanlan E., Schleich S., Schroeter R., Scoffone F., Sekiguchi J.,
RA Sekowska A., Seror S.J., Serror P., Shin B.-S., Soldo B., Sorokin A.,
RA Tacconi E., Takagi T., Takahashi H., Takemaru K., Takeuchi M.,
RA Tamakoshi A., Tanaka T., Terpstra P., Tognoni A., Tosato V., Uchiyama S.,
RA Vandenbol M., Vannier F., Vassarotti A., Viari A., Wambutt R., Wedler E.,
RA Wedler H., Weitzenegger T., Winters P., Wipat A., Yamamoto H., Yamane K.,
RA Yasumoto K., Yata K., Yoshida K., Yoshikawa H.-F., Zumstein E.,
RA Yoshikawa H., Danchin A.;
RT "The complete genome sequence of the Gram-positive bacterium Bacillus
RT subtilis.";
RL Nature 390:249-256(1997).
RN [3]
RP SUBCELLULAR LOCATION, AND DISRUPTION PHENOTYPE.
RC STRAIN=168 / PY79;
RX PubMed=22753055; DOI=10.1128/jb.00910-12;
RA Dempwolff F., Moeller H.M., Graumann P.L.;
RT "Synthetic motility and cell shape defects associated with deletions of
RT flotillin/reggie paralogs in Bacillus subtilis and interplay of these
RT proteins with NfeD proteins.";
RL J. Bacteriol. 194:4652-4661(2012).
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305|PubMed:22753055};
CC Multi-pass membrane protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: No change in localization of FloA or FloT.
CC {ECO:0000269|PubMed:22753055}.
CC -!- SIMILARITY: Belongs to the NfeD family. {ECO:0000305}.
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DR EMBL; D84432; BAA12472.1; -; Genomic_DNA.
DR EMBL; AL009126; CAB14481.1; -; Genomic_DNA.
DR PIR; H69952; H69952.
DR RefSeq; NP_390417.1; NC_000964.3.
DR RefSeq; WP_003230024.1; NZ_JNCM01000036.1.
DR AlphaFoldDB; P54465; -.
DR SMR; P54465; -.
DR STRING; 224308.BSU25390; -.
DR jPOST; P54465; -.
DR PaxDb; P54465; -.
DR PRIDE; P54465; -.
DR EnsemblBacteria; CAB14481; CAB14481; BSU_25390.
DR GeneID; 937859; -.
DR KEGG; bsu:BSU25390; -.
DR PATRIC; fig|224308.179.peg.2760; -.
DR eggNOG; COG1030; Bacteria.
DR InParanoid; P54465; -.
DR OMA; QMDTPGG; -.
DR PhylomeDB; P54465; -.
DR BioCyc; BSUB:BSU25390-MON; -.
DR Proteomes; UP000001570; Chromosome.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR Gene3D; 2.40.50.140; -; 1.
DR InterPro; IPR029045; ClpP/crotonase-like_dom_sf.
DR InterPro; IPR012340; NA-bd_OB-fold.
DR InterPro; IPR002810; NfeD-like_C.
DR InterPro; IPR002825; Pept_S49_ser-pept_pro.
DR Pfam; PF01957; NfeD; 1.
DR Pfam; PF01972; SDH_sah; 1.
DR SUPFAM; SSF52096; SSF52096; 1.
PE 3: Inferred from homology;
KW Cell membrane; Membrane; Reference proteome; Transmembrane;
KW Transmembrane helix.
FT CHAIN 1..437
FT /note="Membrane protein NfeD1b"
FT /id="PRO_0000049792"
FT TRANSMEM 2..22
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 231..251
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 253..273
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 288..308
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TRANSMEM 316..336
FT /note="Helical"
FT /evidence="ECO:0000255"
SQ SEQUENCE 437 AA; 46462 MW; 89BAE117E2A38AFC CRC64;
MLQIKGFRAA LLGIFLLSLL GVQLNAKAEK QTVYVIPVEK NVEQGLASFL SRSLQDAKDA
HADHIILDIN TPGGLVKSAI DMADLITESE IPVTAYVNKR ALSAGAYIAL QADHIYMAPG
GKMGAAAIVD GQGNAADQKA QSLWLAEMED AAVKNNRDPK YALAMADPDI DAKEVGAPKG
DLLTLNADKA IEVGYSEGTA DNLSTLVKKL GFEKAQISYA KESFAEKTAR WLTNPVIVPI
LLTIAFLGLT VELFSPGVGL PGTAGLIALL LFFYGHLAAG LAGYETVLLF IAGVILILLE
IFLPGGIIGL LGLGAIIASL FLAAGSFTVM AVSLLIASAV SITAFILLTR VLGKRMKFFK
KLILNDSTNT ESGYVSNQTR TDLMGKVGIT FTPLRPSGTV IIDDERLDVV SEGSFTEKDK
KVKVIKVEGS RIVVREI
