ID   NFI1L_DANRE             Reviewed;         210 AA.
AC   Q6DGP4;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=NEDD4 family-interacting protein 1-like;
GN   Name=ndfip1l; Synonyms=ndfip1; ORFNames=zgc:92833;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Brain;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in Golgi structure maintenance.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
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DR   EMBL; BC076296; AAH76296.1; -; mRNA.
DR   RefSeq; NP_001002503.1; NM_001002503.2.
DR   RefSeq; XP_009293887.1; XM_009295612.1.
DR   AlphaFoldDB; Q6DGP4; -.
DR   STRING; 7955.ENSDARP00000125987; -.
DR   Ensembl; ENSDART00000166750; ENSDARP00000135351; ENSDARG00000102367.
DR   Ensembl; ENSDART00000171297; ENSDARP00000137128; ENSDARG00000102367.
DR   Ensembl; ENSDART00000174570; ENSDARP00000143559; ENSDARG00000102367.
DR   GeneID; 436776; -.
DR   KEGG; dre:436776; -.
DR   CTD; 436776; -.
DR   ZFIN; ZDB-GENE-040718-207; ndfip1l.
DR   eggNOG; KOG4812; Eukaryota.
DR   GeneTree; ENSGT00390000012721; -.
DR   HOGENOM; CLU_074980_2_0_1; -.
DR   InParanoid; Q6DGP4; -.
DR   PhylomeDB; Q6DGP4; -.
DR   TreeFam; TF324911; -.
DR   PRO; PR:Q6DGP4; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Chromosome 21.
DR   Bgee; ENSDARG00000102367; Expressed in pharyngeal gill and 20 other tissues.
DR   ExpressionAtlas; Q6DGP4; baseline.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR   GO; GO:0050699; F:WW domain binding; IBA:GO_Central.
DR   GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0007034; P:vacuolar transport; IEA:InterPro.
DR   InterPro; IPR019325; NEDD4/Bsd2.
DR   PANTHER; PTHR13396; PTHR13396; 1.
DR   Pfam; PF10176; DUF2370; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..210
FT                   /note="NEDD4 family-interacting protein 1-like"
FT                   /id="PRO_0000076272"
FT   TOPO_DOM        1..105
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        106..126
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        127..132
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        133..153
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        154..161
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        162..182
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        183..210
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..31
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           30..33
FT                   /note="PPxY motif 1"
FT   MOTIF           53..56
FT                   /note="PPxY motif 2"
SQ   SEQUENCE   210 AA;  23776 MW;  A6A0F564689B10F9 CRC64;
     MAEPSGRYQQ LPCEEEPEAG PQVAADAPPP YSSIAADSAA FFDYKDDAAF PNPPSYNVAT
     SLPSYDEAER TKTETSVPLV SGRDDDFVAR DDFEDADQLR IGNDGIFMLT FFMAFLFNWI
     GFFLSFCLTT SAAGRYGAIS GFGLSLIKWI LIVRFSTYFP GYFDGQYWLW WVFLVLGFLL
     FLRGFINYAK IRKMADSFST LPRTRVLFIY