NFIC_CHICK
ID NFIC_CHICK Reviewed; 439 AA.
AC P17926;
DT 01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1990, sequence version 1.
DT 03-AUG-2022, entry version 116.
DE RecName: Full=Nuclear factor 1 C-type;
DE Short=NF1-C;
DE Short=Nuclear factor 1/C;
DE AltName: Full=CCAAT-box-binding transcription factor;
DE Short=CTF;
DE AltName: Full=Nuclear factor I/C;
DE Short=NF-I/C;
DE Short=NFI-C;
DE AltName: Full=TGGCA-binding protein;
GN Name=NFIC; Synonyms=NFI-C;
OS Gallus gallus (Chicken).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC Phasianinae; Gallus.
OX NCBI_TaxID=9031;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Embryo;
RX PubMed=2339052; DOI=10.1093/nar/18.9.2607;
RA Rupp R.A.W., Kruse U., Multhaup G., Goebel U., Beyreuther K., Sippel A.E.;
RT "Chicken NFI/TGGCA proteins are encoded by at least three independent
RT genes: NFI-A, NFI-B and NFI-C with homologues in mammalian genomes.";
RL Nucleic Acids Res. 18:2607-2616(1990).
CC -!- FUNCTION: Recognizes and binds the palindromic sequence 5'-
CC TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the
CC origin of replication of adenovirus type 2. These proteins are
CC individually capable of activating transcription and replication.
CC -!- SUBUNIT: Binds DNA as a homodimer.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced.;
CC Name=1;
CC IsoId=P17926-1; Sequence=Displayed;
CC -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC number of yeast and animal transcription factors.
CC {ECO:0000250|UniProtKB:P08651}.
CC -!- SIMILARITY: Belongs to the CTF/NF-I family. {ECO:0000255|PROSITE-
CC ProRule:PRU00436}.
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DR EMBL; X51483; CAA35850.1; -; mRNA.
DR RefSeq; XP_015155166.1; XM_015299680.1. [P17926-1]
DR AlphaFoldDB; P17926; -.
DR STRING; 9031.ENSGALP00000017751; -.
DR Ensembl; ENSGALT00000083181; ENSGALP00000061240; ENSGALG00000041643. [P17926-1]
DR GeneID; 396208; -.
DR CTD; 4782; -.
DR VEuPathDB; HostDB:geneid_396208; -.
DR eggNOG; KOG3663; Eukaryota.
DR GeneTree; ENSGT00950000182916; -.
DR InParanoid; P17926; -.
DR OrthoDB; 967862at2759; -.
DR PRO; PR:P17926; -.
DR Proteomes; UP000000539; Chromosome 28.
DR Bgee; ENSGALG00000041643; Expressed in cerebellum and 12 other tissues.
DR ExpressionAtlas; P17926; baseline and differential.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProt.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR000647; CTF/NFI.
DR InterPro; IPR020604; CTF/NFI_DNA-bd-dom.
DR InterPro; IPR019739; CTF/NFI_DNA-bd_CS.
DR InterPro; IPR019548; CTF/NFI_DNA-bd_N.
DR InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR PANTHER; PTHR11492; PTHR11492; 1.
DR Pfam; PF00859; CTF_NFI; 1.
DR Pfam; PF03165; MH1; 1.
DR Pfam; PF10524; NfI_DNAbd_pre-N; 1.
DR SMART; SM00523; DWA; 1.
DR PROSITE; PS00349; CTF_NFI_1; 1.
DR PROSITE; PS51080; CTF_NFI_2; 1.
PE 1: Evidence at protein level;
KW Activator; Alternative splicing; Direct protein sequencing;
KW DNA replication; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..439
FT /note="Nuclear factor 1 C-type"
FT /id="PRO_0000100202"
FT DNA_BIND 1..195
FT /note="CTF/NF-I"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00436"
FT REGION 191..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 260..349
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 415..439
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 404..412
FT /note="9aaTAD"
FT /evidence="ECO:0000250|UniProtKB:P08651"
FT COMPBIAS 193..214
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 260..281
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 296..317
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 328..349
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 439 AA; 49233 MW; E9D9DFBBDBB11336 CRC64;
MYSSPLCLTQ DEFHPFIEAL LPHVRAFAYT WFNLQARKRK YFKKHEKRMT KDEERAVKDE
LLSEKPEVKQ KWASRLLAKL RKDIRPECRE DFVLSITGKK PSCCVLSNPD QKGKMRRIDC
LRQADKVWRL DLVMVILFKG IPLESTDGER LVKAGQCTNP ILCIQPHHIS VSVKELDLYL
AYFVRERDSE QSSSPRTGIA SDQEDTKPNT LDSTDFQESF VTSGVFSVTE LIQVSRTPVV
TGTGPNFSLG ELQGHLAYDL NPSSTGMRRT LPSTSSSGSK RHKSGSMEDD IDTSPGGEYY
TSSNSPTSSS RNWTEDMEGG ISPNVKTEMD KSPFNSPSPQ DSSPRLSSFT QHHRPVIAVH
SGIARSPHPS STLHFPTTSI LPQTASTYFP HTAIRYPPHL NPQDPLKDLV SLACDPSNQQ
PGPPTLHQAR PLRTVPSWD
