ID   NFIL3_DANRE             Reviewed;         462 AA.
AC   Q68EL6;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Nuclear factor interleukin-3-regulated protein;
GN   Name=nfil3;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (JUN-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a transcriptional regulator of a number of
CC       proteins of the circadian clock. {ECO:0000250|UniProtKB:O08750}.
CC   -!- SUBUNIT: Homodimer (By similarity). Binds DNA as a dimer (By
CC       similarity). {ECO:0000250|UniProtKB:Q16649}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC   -!- SIMILARITY: Belongs to the bZIP family. NFIL3 subfamily. {ECO:0000305}.
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DR   EMBL; BC080210; AAH80210.1; -; mRNA.
DR   RefSeq; NP_001004120.1; NM_001004120.2.
DR   AlphaFoldDB; Q68EL6; -.
DR   SMR; Q68EL6; -.
DR   STRING; 7955.ENSDARP00000119920; -.
DR   PaxDb; Q68EL6; -.
DR   Ensembl; ENSDART00000190913; ENSDARP00000153020; ENSDARG00000110085.
DR   GeneID; 445509; -.
DR   KEGG; dre:445509; -.
DR   CTD; 4783; -.
DR   ZFIN; ZDB-GENE-040822-28; nfil3.
DR   eggNOG; KOG3119; Eukaryota.
DR   InParanoid; Q68EL6; -.
DR   OrthoDB; 1450431at2759; -.
DR   PhylomeDB; Q68EL6; -.
DR   PRO; PR:Q68EL6; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   Bgee; ENSDARG00000110085; Expressed in post-anal tail bud and 6 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0007623; P:circadian rhythm; IBA:GO_Central.
DR   GO; GO:0007507; P:heart development; IMP:ZFIN.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0061515; P:myeloid cell development; IMP:ZFIN.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR016743; NFIL3/E4BP4.
DR   InterPro; IPR010533; Vert_IL3-reg_TF.
DR   PANTHER; PTHR15284:SF1; PTHR15284:SF1; 1.
DR   Pfam; PF07716; bZIP_2; 1.
DR   Pfam; PF06529; Vert_IL3-reg_TF; 1.
DR   PIRSF; PIRSF019029; bZIP_E4BP4; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   2: Evidence at transcript level;
KW   Activator; Biological rhythms; Cytoplasm; DNA-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..462
FT                   /note="Nuclear factor interleukin-3-regulated protein"
FT                   /id="PRO_0000292671"
FT   DOMAIN          63..126
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          69..85
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          91..112
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          172..210
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          238..289
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        172..203
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        238..259
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  51501 MW;  D9D8DF585B45FFC7 CRC64;
     MQAIKKEPPC SGPYGGEDAL VLAVALQGTD RDLINHKLST LPFKSKSTSC RRKREFIPDE
     KKDNLYWERR RKNNEAAKRS REKRRLNDMV LENKLMALGE ENASLKAELL SLKLRFGLVS
     SAAYAQEVQN ISTSTAALYQ DFMSPSATKD SYPSDLEPTR LTSSCISVIK HSPHSALSDG
     SDSSTVTQGS PLINISRSPD SIKQEPLETG RYSKERISPY ELYRNYLSSP FPGNFSQPSP
     FLQIARSSSN SPRTSDGDDG AVSKSSDNED EQQVPKGPVP TRSDSQSVIV STLKVPDSSA
     SALPHKLRIK ARAIQIKVEA IDPDYESSGK SSFPVDMSAR RRYQMSQCAT PEYIQSSLSP
     MSFQMTNVQD WNHRPKEWHE DHQEALTSYK YRQCPDSPRP VPNKLIVDLE NDSYANSESE
     NLYLKQGIED LSAEVACLKR LISKQQGSVI ESTKSTTEID SS