ID   NFIL3_XENLA             Reviewed;         456 AA.
AC   Q66J36;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Nuclear factor interleukin-3-regulated protein;
GN   Name=nfil3;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a transcriptional regulator of a number of
CC       proteins of the circadian clock. {ECO:0000250|UniProtKB:O08750}.
CC   -!- SUBUNIT: Homodimer (By similarity). Binds DNA as a dimer (By
CC       similarity). {ECO:0000250|UniProtKB:Q16649}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC   -!- SIMILARITY: Belongs to the bZIP family. NFIL3 subfamily. {ECO:0000305}.
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DR   EMBL; BC081074; AAH81074.1; -; mRNA.
DR   RefSeq; NP_001087679.1; NM_001094210.1.
DR   AlphaFoldDB; Q66J36; -.
DR   SMR; Q66J36; -.
DR   GeneID; 447503; -.
DR   KEGG; xla:447503; -.
DR   CTD; 447503; -.
DR   Xenbase; XB-GENE-865288; nfil3.L.
DR   OrthoDB; 1450431at2759; -.
DR   Proteomes; UP000186698; Chromosome 4L.
DR   Bgee; 447503; Expressed in internal ear and 1 other tissue.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0007623; P:circadian rhythm; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR016743; NFIL3/E4BP4.
DR   InterPro; IPR010533; Vert_IL3-reg_TF.
DR   PANTHER; PTHR15284:SF1; PTHR15284:SF1; 1.
DR   Pfam; PF07716; bZIP_2; 1.
DR   Pfam; PF06529; Vert_IL3-reg_TF; 1.
DR   PIRSF; PIRSF019029; bZIP_E4BP4; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   2: Evidence at transcript level;
KW   Activator; Biological rhythms; Cytoplasm; DNA-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..456
FT                   /note="Nuclear factor interleukin-3-regulated protein"
FT                   /id="PRO_0000292672"
FT   DOMAIN          66..129
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          30..49
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          72..88
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          94..115
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          257..297
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        274..288
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   456 AA;  50864 MW;  B5CD515190100FE8 CRC64;
     MPTIKKEQEC ADSRMENILV LSSNIPDMSE SMDSSNDMLY SDGLPVKNKS SSCRRKREFI
     PDEKKDAMYW EKRRKNNEAA KRSREKRRLN DMVLENKLIA LGEENASLKT ELLSLKLKFG
     LISSTSYAQE IQKVTSSTAM YYQEYASSKS NMMSYNSDPE HSVMTSSCIS VIKHSPQSSL
     SDVSEASSSV EHVQPSTIQS NCRSTDIKSQ RIKQEQMEAG NFSRDAREES NTFQGSIYAN
     YIGNTFSGYS HSPPLLHINR SSSNSPRTSE ADEGVVGKTS DVEDEQQVPK GPIHSPIELK
     NGHATIIKVP EVNSSALPHK LRIKAKAMQI KVESLESELN STQKLTLPID MSSKQHLQLE
     KHNSESMVHS SLSPLSVQVT NIQDWPLKPG QWHHRELEKI PSVCKTSGIV AIKDNVYKAS
     ESESLYLKQG IATLSAEVAS LKRLIVTQEI CASNSS