ID   NFIL3_XENTR             Reviewed;         462 AA.
AC   Q5FW38;
DT   26-JUN-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-MAR-2005, sequence version 1.
DT   03-AUG-2022, entry version 104.
DE   RecName: Full=Nuclear factor interleukin-3-regulated protein;
GN   Name=nfil3;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (FEB-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May act as a transcriptional regulator of a number of
CC       proteins of the circadian clock. {ECO:0000250|UniProtKB:O08750}.
CC   -!- SUBUNIT: Homodimer (By similarity). Binds DNA as a dimer (By
CC       similarity). {ECO:0000250|UniProtKB:Q16649}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250}. Nucleus
CC       {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC   -!- SIMILARITY: Belongs to the bZIP family. NFIL3 subfamily. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC089641; AAH89641.1; -; mRNA.
DR   RefSeq; NP_001015710.1; NM_001015710.1.
DR   RefSeq; XP_012817037.1; XM_012961583.2.
DR   RefSeq; XP_012817043.1; XM_012961589.2.
DR   AlphaFoldDB; Q5FW38; -.
DR   SMR; Q5FW38; -.
DR   STRING; 8364.ENSXETP00000038058; -.
DR   PaxDb; Q5FW38; -.
DR   DNASU; 548427; -.
DR   GeneID; 548427; -.
DR   KEGG; xtr:548427; -.
DR   CTD; 4783; -.
DR   Xenbase; XB-GENE-479624; nfil3.
DR   eggNOG; KOG3119; Eukaryota.
DR   HOGENOM; CLU_052045_0_0_1; -.
DR   InParanoid; Q5FW38; -.
DR   OMA; DKIPSVC; -.
DR   OrthoDB; 1450431at2759; -.
DR   PhylomeDB; Q5FW38; -.
DR   TreeFam; TF328374; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000000804; Expressed in brain and 15 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0007623; P:circadian rhythm; IBA:GO_Central.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0045892; P:negative regulation of transcription, DNA-templated; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR016743; NFIL3/E4BP4.
DR   InterPro; IPR010533; Vert_IL3-reg_TF.
DR   PANTHER; PTHR15284:SF1; PTHR15284:SF1; 1.
DR   Pfam; PF07716; bZIP_2; 1.
DR   Pfam; PF06529; Vert_IL3-reg_TF; 1.
DR   PIRSF; PIRSF019029; bZIP_E4BP4; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   2: Evidence at transcript level;
KW   Activator; Biological rhythms; Cytoplasm; DNA-binding; Nucleus;
KW   Reference proteome; Repressor; Transcription; Transcription regulation.
FT   CHAIN           1..462
FT                   /note="Nuclear factor interleukin-3-regulated protein"
FT                   /id="PRO_0000292673"
FT   DOMAIN          73..136
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          79..95
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          101..122
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          263..304
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        280..294
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   462 AA;  51878 MW;  6DD740030DC4E438 CRC64;
     MQLRKMPTIK REQECADSRN NMENILVLSS NIPDMSESMD SSNDMLYSEG APAKNKNSSC
     RRKREFIPDE KKDAMYWEKR RKNNEAAKRS REKRRLNDMV LENKLIALGE ENASLKTELL
     SLKLKFGLIS SASYAQEIQK VTTSTAMYFQ EYSSSKPNVM SYNSDHEHSV MTSSCISVIK
     HSPQSSLSDV SEASSVEHVQ PSTVQSNCRS TDINFQRIKQ EPMERENFSR DAREDSNTFQ
     GSIYTNYIGN TFSGYSHSPP LLHINRSSSN SPRTSEADEG VVGKTSDGED EQQVPKGPIH
     SPVELKNGHT TIIKVPEVNS SALPHKLRIK AKAMQIKVEA LESELNSTQK LTLPIDMSSK
     RHLQLEKHNS ETMVHSSLSP LSVQVTNIQD WPLKPGQWHH RELDKIPSVC KTSGIVDIKD
     NVFKASESES LYLKQGIANL SAEVATLKRL IVTQEICASN SS