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NFILZ_HUMAN
ID   NFILZ_HUMAN             Reviewed;         289 AA.
AC   A0A5F9ZHS7;
DT   17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT   11-DEC-2019, sequence version 1.
DT   03-AUG-2022, entry version 12.
DE   RecName: Full=NFIL3 like protein {ECO:0000305};
DE   AltName: Full=NFIL3 like basic leucine zipper {ECO:0000312|HGNC:HGNC:52681};
GN   Name=NFILZ {ECO:0000312|HGNC:HGNC:52681};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA   Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA   Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA   Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA   Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA   Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA   Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA   Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA   Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA   McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA   Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA   Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA   She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA   Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA   Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC   -!- SIMILARITY: Belongs to the bZIP family. NFIL3 subfamily. {ECO:0000305}.
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DR   EMBL; AC243312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   RefSeq; XP_016855268.1; XM_016999779.1.
DR   RefSeq; XP_016883059.1; XM_017027570.1.
DR   AlphaFoldDB; A0A5F9ZHS7; -.
DR   SMR; A0A5F9ZHS7; -.
DR   PeptideAtlas; A0A5F9ZHS7; -.
DR   Ensembl; ENST00000570582.4; ENSP00000500121.1; ENSG00000268480.4.
DR   Ensembl; ENST00000671902.2; ENSP00000500604.1; ENSG00000268480.4.
DR   Ensembl; ENST00000673603.2; ENSP00000499970.1; ENSG00000268480.4.
DR   Ensembl; ENST00000691075.1; ENSP00000509575.1; ENSG00000268480.4.
DR   MANE-Select; ENST00000691075.1; ENSP00000509575.1; NM_001378600.1; NP_001365529.1.
DR   GeneCards; NFILZ; -.
DR   HGNC; HGNC:52681; NFILZ.
DR   HPA; ENSG00000268480; Tissue enriched (testis).
DR   neXtProt; NX_A0A5F9ZHS7; -.
DR   VEuPathDB; HostDB:ENSG00000268480; -.
DR   GeneTree; ENSGT00940000164108; -.
DR   OMA; WRCLVAH; -.
DR   PRO; PR:A0A5F9ZHS7; -.
DR   Proteomes; UP000005640; Chromosome 19.
DR   Bgee; ENSG00000268480; Expressed in thymus and 40 other tissues.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0006955; P:immune response; IEA:InterPro.
DR   GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR   InterPro; IPR004827; bZIP.
DR   InterPro; IPR046347; bZIP_sf.
DR   InterPro; IPR016743; NFIL3/E4BP4.
DR   PANTHER; PTHR15284:SF1; PTHR15284:SF1; 1.
DR   Pfam; PF07716; bZIP_2; 1.
DR   SMART; SM00338; BRLZ; 1.
DR   SUPFAM; SSF57959; SSF57959; 1.
DR   PROSITE; PS50217; BZIP; 1.
DR   PROSITE; PS00036; BZIP_BASIC; 1.
PE   3: Inferred from homology;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..289
FT                   /note="NFIL3 like protein"
FT                   /id="PRO_0000450365"
FT   DOMAIN          42..105
FT                   /note="bZIP"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          1..27
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          48..64
FT                   /note="Basic motif"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT   REGION          70..91
FT                   /note="Leucine-zipper"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ   SEQUENCE   289 AA;  31047 MW;  49C132DD4B81BFC3 CRC64;
     MDVGFSGLPD VSQSHSKTLW GARGRGPSIR RQREFMPEEK KDTVYWEKRR KNNEAAKRSR
     EKRRLNDAAI EGRLAALMEE NALLKGELKA LKLRFGLLPL TGGPRALPLQ ALLLEAPWTG
     DPRPGAEALS SLSGSHSCLL RPRSLDAGIP GCRGCLLAPR WTGLATSPRS PQESASPTLN
     RIDMALQTAL PPALFSCHLL EGHVGSRPEL RPCWGLWSPV PSGCRASGPS DVLLTPTADP
     MGLSPGVTCP APGNSPEGLG QPSLPHKLRI KSRASGRVPR GWEGGQAPL
 
 
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