NFILZ_HUMAN
ID NFILZ_HUMAN Reviewed; 289 AA.
AC A0A5F9ZHS7;
DT 17-JUN-2020, integrated into UniProtKB/Swiss-Prot.
DT 11-DEC-2019, sequence version 1.
DT 03-AUG-2022, entry version 12.
DE RecName: Full=NFIL3 like protein {ECO:0000305};
DE AltName: Full=NFIL3 like basic leucine zipper {ECO:0000312|HGNC:HGNC:52681};
GN Name=NFILZ {ECO:0000312|HGNC:HGNC:52681};
OS Homo sapiens (Human).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC Homo.
OX NCBI_TaxID=9606;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX PubMed=15057824; DOI=10.1038/nature02399;
RA Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E.,
RA Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A.,
RA Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S.,
RA Carrano A.V., Caoile C., Chan Y.M., Christensen M., Cleland C.A.,
RA Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J.,
RA Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M.,
RA Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W.,
RA Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V.,
RA Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D.,
RA McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I.,
RA Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L.,
RA Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A.,
RA She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M.,
RA Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J.,
RA Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA Rubin E.M., Lucas S.M.;
RT "The DNA sequence and biology of human chromosome 19.";
RL Nature 428:529-535(2004).
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00978}.
CC -!- SIMILARITY: Belongs to the bZIP family. NFIL3 subfamily. {ECO:0000305}.
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DR EMBL; AC243312; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_016855268.1; XM_016999779.1.
DR RefSeq; XP_016883059.1; XM_017027570.1.
DR AlphaFoldDB; A0A5F9ZHS7; -.
DR SMR; A0A5F9ZHS7; -.
DR PeptideAtlas; A0A5F9ZHS7; -.
DR Ensembl; ENST00000570582.4; ENSP00000500121.1; ENSG00000268480.4.
DR Ensembl; ENST00000671902.2; ENSP00000500604.1; ENSG00000268480.4.
DR Ensembl; ENST00000673603.2; ENSP00000499970.1; ENSG00000268480.4.
DR Ensembl; ENST00000691075.1; ENSP00000509575.1; ENSG00000268480.4.
DR MANE-Select; ENST00000691075.1; ENSP00000509575.1; NM_001378600.1; NP_001365529.1.
DR GeneCards; NFILZ; -.
DR HGNC; HGNC:52681; NFILZ.
DR HPA; ENSG00000268480; Tissue enriched (testis).
DR neXtProt; NX_A0A5F9ZHS7; -.
DR VEuPathDB; HostDB:ENSG00000268480; -.
DR GeneTree; ENSGT00940000164108; -.
DR OMA; WRCLVAH; -.
DR PRO; PR:A0A5F9ZHS7; -.
DR Proteomes; UP000005640; Chromosome 19.
DR Bgee; ENSG00000268480; Expressed in thymus and 40 other tissues.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0006955; P:immune response; IEA:InterPro.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IEA:InterPro.
DR InterPro; IPR004827; bZIP.
DR InterPro; IPR046347; bZIP_sf.
DR InterPro; IPR016743; NFIL3/E4BP4.
DR PANTHER; PTHR15284:SF1; PTHR15284:SF1; 1.
DR Pfam; PF07716; bZIP_2; 1.
DR SMART; SM00338; BRLZ; 1.
DR SUPFAM; SSF57959; SSF57959; 1.
DR PROSITE; PS50217; BZIP; 1.
DR PROSITE; PS00036; BZIP_BASIC; 1.
PE 3: Inferred from homology;
KW DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..289
FT /note="NFIL3 like protein"
FT /id="PRO_0000450365"
FT DOMAIN 42..105
FT /note="bZIP"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 48..64
FT /note="Basic motif"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
FT REGION 70..91
FT /note="Leucine-zipper"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00978"
SQ SEQUENCE 289 AA; 31047 MW; 49C132DD4B81BFC3 CRC64;
MDVGFSGLPD VSQSHSKTLW GARGRGPSIR RQREFMPEEK KDTVYWEKRR KNNEAAKRSR
EKRRLNDAAI EGRLAALMEE NALLKGELKA LKLRFGLLPL TGGPRALPLQ ALLLEAPWTG
DPRPGAEALS SLSGSHSCLL RPRSLDAGIP GCRGCLLAPR WTGLATSPRS PQESASPTLN
RIDMALQTAL PPALFSCHLL EGHVGSRPEL RPCWGLWSPV PSGCRASGPS DVLLTPTADP
MGLSPGVTCP APGNSPEGLG QPSLPHKLRI KSRASGRVPR GWEGGQAPL