ID   NFIP1_XENTR             Reviewed;         211 AA.
AC   Q4V786;
DT   06-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2005, sequence version 1.
DT   03-AUG-2022, entry version 73.
DE   RecName: Full=NEDD4 family-interacting protein 1;
GN   Name=ndfip1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUN-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May play a role in Golgi structure maintenance.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Golgi apparatus membrane {ECO:0000250}; Multi-
CC       pass membrane protein {ECO:0000250}.
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DR   EMBL; BC098082; AAH98082.1; -; mRNA.
DR   RefSeq; NP_001027505.1; NM_001032334.1.
DR   AlphaFoldDB; Q4V786; -.
DR   STRING; 8364.ENSXETP00000003388; -.
DR   PaxDb; Q4V786; -.
DR   DNASU; 613097; -.
DR   Ensembl; ENSXETT00000038608; ENSXETP00000038608; ENSXETG00000019569.
DR   GeneID; 613097; -.
DR   KEGG; xtr:613097; -.
DR   CTD; 80762; -.
DR   Xenbase; XB-GENE-961957; ndfip1.
DR   eggNOG; KOG4812; Eukaryota.
DR   HOGENOM; CLU_074980_2_0_1; -.
DR   InParanoid; Q4V786; -.
DR   OrthoDB; 1495850at2759; -.
DR   Proteomes; UP000008143; Chromosome 3.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000019569; Expressed in brain and 19 other tissues.
DR   GO; GO:0005783; C:endoplasmic reticulum; IBA:GO_Central.
DR   GO; GO:0005794; C:Golgi apparatus; IBA:GO_Central.
DR   GO; GO:0000139; C:Golgi membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; IBA:GO_Central.
DR   GO; GO:0050699; F:WW domain binding; IBA:GO_Central.
DR   GO; GO:0030001; P:metal ion transport; IBA:GO_Central.
DR   GO; GO:0031398; P:positive regulation of protein ubiquitination; IBA:GO_Central.
DR   GO; GO:0006511; P:ubiquitin-dependent protein catabolic process; IBA:GO_Central.
DR   GO; GO:0007034; P:vacuolar transport; IEA:InterPro.
DR   InterPro; IPR019325; NEDD4/Bsd2.
DR   PANTHER; PTHR13396; PTHR13396; 1.
DR   Pfam; PF10176; DUF2370; 1.
PE   2: Evidence at transcript level;
KW   Golgi apparatus; Membrane; Reference proteome; Repeat; Transmembrane;
KW   Transmembrane helix.
FT   CHAIN           1..211
FT                   /note="NEDD4 family-interacting protein 1"
FT                   /id="PRO_0000076274"
FT   TOPO_DOM        1..106
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        107..127
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        128..133
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        134..154
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        155..162
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        163..183
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        184..211
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   REGION          1..48
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           29..32
FT                   /note="PPxY motif 1"
FT   MOTIF           54..57
FT                   /note="PPxY motif 2"
FT   COMPBIAS        1..33
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   211 AA;  24056 MW;  11436B624B1245B1 CRC64;
     MSEQSSSRYQ QLQNEEEPGE NPQASTDAPP PYSSIAGESS GLFDYKDELG FPKPPSYNVA
     TSLPSYDEAE RTKAEATIPL VPGRDDDFVA RDDFDDADQL RIGNDGIFML TFFMAFLFNW
     IGFFLSFCLT SSAAGRYGAI SGFGLSLIKW ILIVRFSTYF PGYFDGQYWL WWVFLVLGFL
     LFLRGFINYA KVRKMPDNFS TLPRTRVLFI Y