ID   NFIX_CHICK              Reviewed;         431 AA.
AC   Q90932;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 108.
DE   RecName: Full=Nuclear factor 1 X-type;
DE            Short=NF1-X;
DE            Short=Nuclear factor 1/X;
DE   AltName: Full=CCAAT-box-binding transcription factor;
DE            Short=CTF;
DE   AltName: Full=Nuclear factor I/X;
DE            Short=NF-I/X;
DE            Short=NFI-X;
DE   AltName: Full=TGGCA-binding protein;
GN   Name=NFIX; Synonyms=NFI-X;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=1754401; DOI=10.1093/nar/19.23.6641;
RA   Kruse U., Qian F., Sippel A.E.;
RT   "Identification of a fourth nuclear factor I gene in chicken by cDNA
RT   cloning: NFI-X.";
RL   Nucleic Acids Res. 19:6641-6641(1991).
CC   -!- FUNCTION: Recognizes and binds the palindromic sequence 5'-
CC       TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the
CC       origin of replication of adenovirus type 2. These proteins are
CC       individually capable of activating transcription and replication.
CC   -!- SUBUNIT: Binds DNA as a homodimer.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=1;
CC         Comment=A number of isoforms are produced.;
CC       Name=1;
CC         IsoId=Q90932-1; Sequence=Displayed;
CC   -!- DOMAIN: The 9aaTAD motif is a transactivation domain present in a large
CC       number of yeast and animal transcription factors.
CC       {ECO:0000250|UniProtKB:Q14938}.
CC   -!- SIMILARITY: Belongs to the CTF/NF-I family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00436}.
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DR   EMBL; X61225; CAA43537.1; -; mRNA.
DR   PIR; S20065; S20065.
DR   RefSeq; NP_990601.1; NM_205270.1. [Q90932-1]
DR   AlphaFoldDB; Q90932; -.
DR   PRIDE; Q90932; -.
DR   GeneID; 396207; -.
DR   KEGG; gga:396207; -.
DR   CTD; 4784; -.
DR   VEuPathDB; HostDB:geneid_396207; -.
DR   InParanoid; Q90932; -.
DR   OrthoDB; 967862at2759; -.
DR   PhylomeDB; Q90932; -.
DR   PRO; PR:Q90932; -.
DR   Proteomes; UP000000539; Unplaced.
DR   GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR   GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IEA:UniProt.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   InterPro; IPR000647; CTF/NFI.
DR   InterPro; IPR020604; CTF/NFI_DNA-bd-dom.
DR   InterPro; IPR019739; CTF/NFI_DNA-bd_CS.
DR   InterPro; IPR019548; CTF/NFI_DNA-bd_N.
DR   InterPro; IPR003619; MAD_homology1_Dwarfin-type.
DR   PANTHER; PTHR11492; PTHR11492; 1.
DR   Pfam; PF00859; CTF_NFI; 1.
DR   Pfam; PF03165; MH1; 1.
DR   Pfam; PF10524; NfI_DNAbd_pre-N; 1.
DR   SMART; SM00523; DWA; 1.
DR   PROSITE; PS00349; CTF_NFI_1; 1.
DR   PROSITE; PS51080; CTF_NFI_2; 1.
PE   2: Evidence at transcript level;
KW   Activator; Alternative splicing; DNA replication; DNA-binding; Nucleus;
KW   Reference proteome; Transcription; Transcription regulation.
FT   CHAIN           1..431
FT                   /note="Nuclear factor 1 X-type"
FT                   /id="PRO_0000100206"
FT   DNA_BIND        1..194
FT                   /note="CTF/NF-I"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00436"
FT   REGION          259..319
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          404..431
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   MOTIF           389..397
FT                   /note="9aaTAD"
FT                   /evidence="ECO:0000250|UniProtKB:Q14938"
SQ   SEQUENCE   431 AA;  46903 MW;  83989A0292E74D6C CRC64;
     MYSPYCLTQD EFHPFIEALL PHVRAFSYTW FNLQARKRKY FKKHEKRMSK EEERAVKDEL
     LGEKPEVKQK WASRLLAKLR KDIRPECRED FVLSVTGKKA PCCVLSNPDQ KGKIRRIDCL
     RQADKVWRLD LVMVILFKGV PLESTDGERL AKAPQCASPG LCVQPHHIGV TIKELDLYLA
     FFVQAPDSGQ SDSSNPQGDA DIKPLPNGHL SFQDCFVTSG VWNVTELVRV SQTPVATASG
     PNFSLADLES PGGYYNISPV TLGRRPLGPP TASGPKRPKA LDEGDLEGPG DDVFYSGPGR
     SPAPGSSQGP WGGDVDTSPA TLKKSGKLDF CSALSGHAAS PRMAFGHHPL PVLAGVRPAS
     ALHFPSGSLL PQSGPYFAHP TIRYHHGQDS LKDFVQFVCA DGAAQGPQHS QRPAPPLPPA
     LSASDPATAT F