NFKI1_CAEEL
ID NFKI1_CAEEL Reviewed; 611 AA.
AC G5EDE9;
DT 10-OCT-2018, integrated into UniProtKB/Swiss-Prot.
DT 14-DEC-2011, sequence version 1.
DT 03-AUG-2022, entry version 72.
DE RecName: Full=ANK repeat-containing protein nipk-1 {ECO:0000305};
GN Name=nfki-1 {ECO:0000303|PubMed:28099418, ECO:0000312|WormBase:C33A11.1};
GN Synonyms=nbid-1 {ECO:0000312|WormBase:C33A11.1};
GN ORFNames=C33A11.1 {ECO:0000312|WormBase:C33A11.1};
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239 {ECO:0000312|Proteomes:UP000001940};
RN [1] {ECO:0000312|Proteomes:UP000001940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2 {ECO:0000312|Proteomes:UP000001940};
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [2] {ECO:0000305}
RP FUNCTION, TISSUE SPECIFICITY, AND MUTAGENESIS OF 179-GLN--ALA-611; ASP-247
RP AND 286-ARG--ALA-611.
RX PubMed=28099418; DOI=10.1038/nature20818;
RA Chen C., Itakura E., Nelson G.M., Sheng M., Laurent P., Fenk L.A.,
RA Butcher R.A., Hegde R.S., de Bono M.;
RT "IL-17 is a neuromodulator of Caenorhabditis elegans sensory responses.";
RL Nature 542:43-48(2017).
CC -!- FUNCTION: Acts downstream of the receptor complex composed of ilcr-1
CC and ilcr-2, which is a signaling complex that modulates neuronal
CC activity and animal behavior in response to sensory neuron input.
CC Mediates signaling of the complex. {ECO:0000269|PubMed:28099418}.
CC -!- TISSUE SPECIFICITY: Expressed in the nervous system.
CC {ECO:0000269|PubMed:28099418}.
CC -!- SIMILARITY: Belongs to the iASPP family. {ECO:0000305}.
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DR EMBL; BX284606; CAB01860.2; -; Genomic_DNA.
DR PIR; E89722; E89722.
DR PIR; T19653; T19653.
DR RefSeq; NP_510540.1; NM_078139.4.
DR AlphaFoldDB; G5EDE9; -.
DR SMR; G5EDE9; -.
DR STRING; 6239.C33A11.1.1; -.
DR EPD; G5EDE9; -.
DR PaxDb; G5EDE9; -.
DR PeptideAtlas; G5EDE9; -.
DR EnsemblMetazoa; C33A11.1.1; C33A11.1.1; WBGene00007877.
DR GeneID; 181625; -.
DR KEGG; cel:CELE_C33A11.1; -.
DR CTD; 181625; -.
DR WormBase; C33A11.1; CE24824; WBGene00007877; nfki-1.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000160551; -.
DR HOGENOM; CLU_458733_0_0_1; -.
DR InParanoid; G5EDE9; -.
DR OMA; GSGYECG; -.
DR OrthoDB; 750283at2759; -.
DR PhylomeDB; G5EDE9; -.
DR PRO; PR:G5EDE9; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00007877; Expressed in pharyngeal muscle cell (C elegans) and 3 other tissues.
DR GO; GO:0045597; P:positive regulation of cell differentiation; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR Gene3D; 1.25.40.20; -; 2.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR028320; iASPP.
DR PANTHER; PTHR24164; PTHR24164; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF13637; Ank_4; 1.
DR SMART; SM00248; ANK; 6.
DR SUPFAM; SSF48403; SSF48403; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 1.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 1: Evidence at protein level;
KW ANK repeat; Coiled coil; Reference proteome; Repeat.
FT CHAIN 1..611
FT /note="ANK repeat-containing protein nipk-1"
FT /evidence="ECO:0000305"
FT /id="PRO_0000445234"
FT REPEAT 375..405
FT /note="ANK 1"
FT /evidence="ECO:0000255"
FT REPEAT 417..446
FT /note="ANK 2"
FT /evidence="ECO:0000255"
FT REPEAT 452..482
FT /note="ANK 3"
FT /evidence="ECO:0000255"
FT REPEAT 486..527
FT /note="ANK 4"
FT /evidence="ECO:0000255"
FT REPEAT 532..561
FT /note="ANK 5"
FT /evidence="ECO:0000255"
FT REGION 92..167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 212..255
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 280..333
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 91..149
FT /evidence="ECO:0000255"
FT COMPBIAS 92..151
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 314..333
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MUTAGEN 179..611
FT /note="Missing: Defective aggregation behavior."
FT /evidence="ECO:0000269|PubMed:28099418"
FT MUTAGEN 247
FT /note="D->G: Defective aggregation behavior."
FT /evidence="ECO:0000269|PubMed:28099418"
FT MUTAGEN 286..611
FT /note="Missing: Defective aggregation behavior."
FT /evidence="ECO:0000269|PubMed:28099418"
SQ SEQUENCE 611 AA; 66539 MW; 5D4DEC8B0080DEC8 CRC64;
MATVAPKGNC LVARAIPSDS HADQLTDLLC KLSVNGDANQ KSVNKFESQH GVTPSDFRDI
QNIRSSALAK KTKTSKFQLD GVTLFADLTP NSKSKKKTEN QETKEKDEEA EEKKDGPPKD
DKELKMKKEK EQEDENAELD EQKKDGDLLG RGPVHNVRVA TGGSHPYHRA QIPYGCAAQT
PITDISAYTG YGSGYECGST WSLSPDTTIG SISASTTPDT VLSSDGYGSA SPPQHSPKES
LQSPFSDISS ADTSRVLTPE NNELPESLQD FILQYSNQYT KEESIRGRPP SADSGVSSPM
SARSAPYASP HVPQGTCSGP TTPSFNQTRL SPRTSENGIT AKQRLNAIIP ESDLATGFHW
ACTTWKNVLT NRDADGDTPL HIVAAHNDLG KIYALCETLR KTMNENDDNV FNVSNNFGET
PLYVAVLQRS IEVVEYLLEL GASPNSRSSR AVGDSPLHFA TARGMNNMVE ALLSKREIRV
NETNDDGQTS LLCAVKMHGM MDEQTQHKID NKSIIEMLIK AGADPTIAET STGKTIVHHA
VDKMDVELLD FLKTVVNEDT FTELANLSDF HGDTAVDLLC SSTQNEDTNN VRENLYIRLL
TSGAVPNKSR A
