ID   NFRA_STAA3              Reviewed;         251 AA.
AC   Q2FJN3;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   21-MAR-2006, sequence version 1.
DT   03-AUG-2022, entry version 74.
DE   RecName: Full=NADPH-dependent oxidoreductase;
DE            EC=1.6.-.-;
GN   Name=nfrA; OrderedLocusNames=SAUSA300_0381;
OS   Staphylococcus aureus (strain USA300).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=367830;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=USA300;
RX   PubMed=16517273; DOI=10.1016/s0140-6736(06)68231-7;
RA   Diep B.A., Gill S.R., Chang R.F., Phan T.H., Chen J.H., Davidson M.G.,
RA   Lin F., Lin J., Carleton H.A., Mongodin E.F., Sensabaugh G.F.,
RA   Perdreau-Remington F.;
RT   "Complete genome sequence of USA300, an epidemic clone of community-
RT   acquired meticillin-resistant Staphylococcus aureus.";
RL   Lancet 367:731-739(2006).
CC   -!- FUNCTION: Reduces FMN, organic nitro compounds and disulfide DTNB.
CC       Involved in maintenance of the cellular redox state and the disulfide
CC       stress response (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the flavin oxidoreductase frp family.
CC       {ECO:0000305}.
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DR   EMBL; CP000255; ABD21165.1; -; Genomic_DNA.
DR   RefSeq; WP_001289311.1; NZ_CP027476.1.
DR   AlphaFoldDB; Q2FJN3; -.
DR   SMR; Q2FJN3; -.
DR   PRIDE; Q2FJN3; -.
DR   EnsemblBacteria; ABD21165; ABD21165; SAUSA300_0381.
DR   KEGG; saa:SAUSA300_0381; -.
DR   HOGENOM; CLU_070764_0_0_9; -.
DR   OMA; GMCLGYP; -.
DR   Proteomes; UP000001939; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02146; NfsA-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR016446; Flavin_OxRdtase_Frp.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   PANTHER; PTHR43425; PTHR43425; 1.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   PIRSF; PIRSF005426; Frp; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NADP; Oxidoreductase.
FT   CHAIN           1..251
FT                   /note="NADPH-dependent oxidoreductase"
FT                   /id="PRO_0000239727"
SQ   SEQUENCE   251 AA;  28597 MW;  1355044E1B8F11F0 CRC64;
     MSEHVYNLVK KHHSVRKFKN KPLSEDVVKK LVEAGQSAST SSFLQAYSII GIDDEKIKEN
     LREVSGQPYV VENGYLFVFV IDYYRHHLVD QHAETDMENA YGSTEGLLVG AIDAALVAEN
     IAVTAEDMGY GIVFLGSLRN DVERVREILD LPDYVFPVFG MAVGEPADDE NGAAKPRLPF
     DHVFHHNKYH ADKETQYAQM ADYDQTISEY YDQRTNGNRK ETWSQQIEMF LGNKARLDML
     EQLQKSGLIQ R