ID   NFRA_STAAM              Reviewed;         251 AA.
AC   Q99WJ6;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-2001, sequence version 1.
DT   03-AUG-2022, entry version 100.
DE   RecName: Full=NADPH-dependent oxidoreductase;
DE            EC=1.6.-.-;
GN   Name=nfrA; OrderedLocusNames=SAV0382;
OS   Staphylococcus aureus (strain Mu50 / ATCC 700699).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=158878;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Mu50 / ATCC 700699;
RX   PubMed=11418146; DOI=10.1016/s0140-6736(00)04403-2;
RA   Kuroda M., Ohta T., Uchiyama I., Baba T., Yuzawa H., Kobayashi I., Cui L.,
RA   Oguchi A., Aoki K., Nagai Y., Lian J.-Q., Ito T., Kanamori M.,
RA   Matsumaru H., Maruyama A., Murakami H., Hosoyama A., Mizutani-Ui Y.,
RA   Takahashi N.K., Sawano T., Inoue R., Kaito C., Sekimizu K., Hirakawa H.,
RA   Kuhara S., Goto S., Yabuzaki J., Kanehisa M., Yamashita A., Oshima K.,
RA   Furuya K., Yoshino C., Shiba T., Hattori M., Ogasawara N., Hayashi H.,
RA   Hiramatsu K.;
RT   "Whole genome sequencing of meticillin-resistant Staphylococcus aureus.";
RL   Lancet 357:1225-1240(2001).
CC   -!- FUNCTION: Reduces FMN, organic nitro compounds and disulfide DTNB.
CC       Involved in maintenance of the cellular redox state and the disulfide
CC       stress response (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the flavin oxidoreductase frp family.
CC       {ECO:0000305}.
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DR   EMBL; BA000017; BAB56544.1; -; Genomic_DNA.
DR   RefSeq; WP_001287099.1; NC_002758.2.
DR   AlphaFoldDB; Q99WJ6; -.
DR   SMR; Q99WJ6; -.
DR   World-2DPAGE; 0002:Q99WJ6; -.
DR   PaxDb; Q99WJ6; -.
DR   EnsemblBacteria; BAB56544; BAB56544; SAV0382.
DR   KEGG; sav:SAV0382; -.
DR   HOGENOM; CLU_070764_0_0_9; -.
DR   OMA; GMCLGYP; -.
DR   PhylomeDB; Q99WJ6; -.
DR   BioCyc; SAUR158878:SAV_RS02105-MON; -.
DR   Proteomes; UP000002481; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02146; NfsA-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR016446; Flavin_OxRdtase_Frp.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   PANTHER; PTHR43425; PTHR43425; 1.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   PIRSF; PIRSF005426; Frp; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NADP; Oxidoreductase.
FT   CHAIN           1..251
FT                   /note="NADPH-dependent oxidoreductase"
FT                   /id="PRO_0000239725"
SQ   SEQUENCE   251 AA;  28609 MW;  16100445AB3F11F7 CRC64;
     MSDYVYNLVK KHHSVRKFKN KPLSEDVVKK LVEAGQSAST SSFLQAYSII GIDDEKIKEN
     LREVSGQPYV VENGYLFVFV IDYYRHHLVD QHAETDMENA YGSTEGLLVG AIDAALVAEN
     IAVTAEDMGY GIVFLGSLRN DVERVREILD LPDYVFPVFG MAVGEPADDE NGAAKPRLPF
     DHVFHHNKYH ADKETQYAQM ADYDQTISEY YDQRTNGNRK ETWSQQIEMF LGNKARLDML
     EQLQKSGLIQ R