ID   NFRA_STAEQ              Reviewed;         251 AA.
AC   Q5HRX9;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   15-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=NADPH-dependent oxidoreductase;
DE            EC=1.6.-.-;
GN   Name=nfrA; OrderedLocusNames=SERP0062;
OS   Staphylococcus epidermidis (strain ATCC 35984 / RP62A).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176279;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 35984 / RP62A;
RX   PubMed=15774886; DOI=10.1128/jb.187.7.2426-2438.2005;
RA   Gill S.R., Fouts D.E., Archer G.L., Mongodin E.F., DeBoy R.T., Ravel J.,
RA   Paulsen I.T., Kolonay J.F., Brinkac L.M., Beanan M.J., Dodson R.J.,
RA   Daugherty S.C., Madupu R., Angiuoli S.V., Durkin A.S., Haft D.H.,
RA   Vamathevan J.J., Khouri H., Utterback T.R., Lee C., Dimitrov G., Jiang L.,
RA   Qin H., Weidman J., Tran K., Kang K.H., Hance I.R., Nelson K.E.,
RA   Fraser C.M.;
RT   "Insights on evolution of virulence and resistance from the complete genome
RT   analysis of an early methicillin-resistant Staphylococcus aureus strain and
RT   a biofilm-producing methicillin-resistant Staphylococcus epidermidis
RT   strain.";
RL   J. Bacteriol. 187:2426-2438(2005).
CC   -!- FUNCTION: Reduces FMN, organic nitro compounds and disulfide DTNB.
CC       Involved in maintenance of the cellular redox state and the disulfide
CC       stress response (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the flavin oxidoreductase frp family.
CC       {ECO:0000305}.
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DR   EMBL; CP000029; AAW53453.1; -; Genomic_DNA.
DR   RefSeq; WP_002455899.1; NC_002976.3.
DR   AlphaFoldDB; Q5HRX9; -.
DR   SMR; Q5HRX9; -.
DR   STRING; 176279.SERP0062; -.
DR   EnsemblBacteria; AAW53453; AAW53453; SERP0062.
DR   GeneID; 50019666; -.
DR   KEGG; ser:SERP0062; -.
DR   eggNOG; COG0778; Bacteria.
DR   HOGENOM; CLU_070764_0_0_9; -.
DR   OMA; GMCLGYP; -.
DR   Proteomes; UP000000531; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02146; NfsA-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR016446; Flavin_OxRdtase_Frp.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   PANTHER; PTHR43425; PTHR43425; 1.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   PIRSF; PIRSF005426; Frp; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..251
FT                   /note="NADPH-dependent oxidoreductase"
FT                   /id="PRO_0000239729"
SQ   SEQUENCE   251 AA;  28600 MW;  30183CE3A4DED52B CRC64;
     MSDYVYELMK QHHSVRKFKN QPLGSETVEK LVEAGQSAST SSYLQTYSII GVEDPSIKAR
     LKEVSGQPYV LDNGYLFVFV LDYYRHHLVD EVAASNMETS YGSAEGLLVG TIDVALVAQN
     MAVAAEDMGY GIVYLGSLRN DVARVREILN LPDYTFPLFG MAVGEPSDEE NGSPKPRLPF
     KHIFHKDQYD ANQHQQRKEL EAYDQVVSEY YKERTHGVRT ENWSQQIETF LGRKTRLDML
     DELKKAGFIQ R