ID   NFRA_STAES              Reviewed;         251 AA.
AC   Q8CMQ4;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 2.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=NADPH-dependent oxidoreductase;
DE            EC=1.6.-.-;
GN   Name=nfrA; OrderedLocusNames=SE_2355;
OS   Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=176280;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 12228 / FDA PCI 1200;
RX   PubMed=12950922; DOI=10.1046/j.1365-2958.2003.03671.x;
RA   Zhang Y.-Q., Ren S.-X., Li H.-L., Wang Y.-X., Fu G., Yang J., Qin Z.-Q.,
RA   Miao Y.-G., Wang W.-Y., Chen R.-S., Shen Y., Chen Z., Yuan Z.-H.,
RA   Zhao G.-P., Qu D., Danchin A., Wen Y.-M.;
RT   "Genome-based analysis of virulence genes in a non-biofilm-forming
RT   Staphylococcus epidermidis strain (ATCC 12228).";
RL   Mol. Microbiol. 49:1577-1593(2003).
CC   -!- FUNCTION: Reduces FMN, organic nitro compounds and disulfide DTNB.
CC       Involved in maintenance of the cellular redox state and the disulfide
CC       stress response (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the flavin oxidoreductase frp family.
CC       {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAO05998.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AE015929; AAO05998.1; ALT_INIT; Genomic_DNA.
DR   RefSeq; NP_765910.1; NC_004461.1.
DR   RefSeq; WP_002485228.1; NC_004461.1.
DR   AlphaFoldDB; Q8CMQ4; -.
DR   SMR; Q8CMQ4; -.
DR   STRING; 176280.SE_2355; -.
DR   EnsemblBacteria; AAO05998; AAO05998; SE_2355.
DR   KEGG; sep:SE_2355; -.
DR   PATRIC; fig|176280.10.peg.2298; -.
DR   eggNOG; COG0778; Bacteria.
DR   HOGENOM; CLU_070764_0_0_9; -.
DR   Proteomes; UP000001411; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02146; NfsA-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR016446; Flavin_OxRdtase_Frp.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   PANTHER; PTHR43425; PTHR43425; 1.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   PIRSF; PIRSF005426; Frp; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NADP; Oxidoreductase.
FT   CHAIN           1..251
FT                   /note="NADPH-dependent oxidoreductase"
FT                   /id="PRO_0000239728"
SQ   SEQUENCE   251 AA;  28577 MW;  300DDCE65E81752B CRC64;
     MSDYVYELMK QHHSVRKFKN QPLGSETVEK LVEAGQSAST SSYLQTYSII GVEDPSIKAR
     LKEVSGQPYV LDNGYLFVFV LDYYRHHLVD EVAASNMETS YGSAEGLLVG TIDVALVAQN
     MAVAAEDMGY GIVYLGSLRN DVARVREILN LPDYTFPLFG MAVGEPSDEE NGSPKPRLPF
     KHIFHKDQYD ANQHQQRKEL EAYDQVVSEY YKERTNGVRT ENWSQQIETF LGRKTRLDML
     DELKKAGFIK R