ID   NFRA_STAHJ              Reviewed;         251 AA.
AC   Q4L378;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   25-MAY-2022, entry version 103.
DE   RecName: Full=NADPH-dependent oxidoreductase;
DE            EC=1.6.-.-;
GN   Name=nfrA; OrderedLocusNames=SH2590;
OS   Staphylococcus haemolyticus (strain JCSC1435).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=279808;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=JCSC1435;
RX   PubMed=16237012; DOI=10.1128/jb.187.21.7292-7308.2005;
RA   Takeuchi F., Watanabe S., Baba T., Yuzawa H., Ito T., Morimoto Y.,
RA   Kuroda M., Cui L., Takahashi M., Ankai A., Baba S., Fukui S., Lee J.C.,
RA   Hiramatsu K.;
RT   "Whole-genome sequencing of Staphylococcus haemolyticus uncovers the
RT   extreme plasticity of its genome and the evolution of human-colonizing
RT   staphylococcal species.";
RL   J. Bacteriol. 187:7292-7308(2005).
CC   -!- FUNCTION: Reduces FMN, organic nitro compounds and disulfide DTNB.
CC       Involved in maintenance of the cellular redox state and the disulfide
CC       stress response (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the flavin oxidoreductase frp family.
CC       {ECO:0000305}.
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DR   EMBL; AP006716; BAE05899.1; -; Genomic_DNA.
DR   RefSeq; WP_011276836.1; NC_007168.1.
DR   AlphaFoldDB; Q4L378; -.
DR   SMR; Q4L378; -.
DR   STRING; 279808.SH2590; -.
DR   PRIDE; Q4L378; -.
DR   EnsemblBacteria; BAE05899; BAE05899; SH2590.
DR   KEGG; sha:SH2590; -.
DR   eggNOG; COG0778; Bacteria.
DR   HOGENOM; CLU_070764_0_0_9; -.
DR   OMA; GMCLGYP; -.
DR   OrthoDB; 1847197at2; -.
DR   Proteomes; UP000000543; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02146; NfsA-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR016446; Flavin_OxRdtase_Frp.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   PANTHER; PTHR43425; PTHR43425; 1.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   PIRSF; PIRSF005426; Frp; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NADP; Oxidoreductase.
FT   CHAIN           1..251
FT                   /note="NADPH-dependent oxidoreductase"
FT                   /id="PRO_0000239730"
SQ   SEQUENCE   251 AA;  28492 MW;  B984F09B99FB14E7 CRC64;
     MSDYVYDLMK KHHSVRQFKD KALSDETVQK LVEAGQSAST SSYLQTYSII GVDDPEIKKQ
     LKEVSGQPYV VDNGYLFVFV LDYYRHNLIN ENVDFDMQTS FESAEGLLVG AIDVALVSEN
     VALAAEDMGY GIVYLGSLRN DVARVKEILD LPEYAFPLFG MAVGEPADDE NGAPKPRLPF
     EHVFHKNVYN SNAKEQREAI QKYDEEISEY YKERTNGKRQ ETWSQQVAGF LSGKTRLDML
     EELNKSGLMK K