ID   NFRA_STAS1              Reviewed;         251 AA.
AC   Q49UU0;
DT   13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT   13-SEP-2005, sequence version 1.
DT   25-MAY-2022, entry version 94.
DE   RecName: Full=NADPH-dependent oxidoreductase;
DE            EC=1.6.-.-;
GN   Name=nfrA; OrderedLocusNames=SSP2331;
OS   Staphylococcus saprophyticus subsp. saprophyticus (strain ATCC 15305 / DSM
OS   20229 / NCIMB 8711 / NCTC 7292 / S-41).
OC   Bacteria; Firmicutes; Bacilli; Bacillales; Staphylococcaceae;
OC   Staphylococcus.
OX   NCBI_TaxID=342451;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 15305 / DSM 20229 / NCIMB 8711 / NCTC 7292 / S-41;
RX   PubMed=16135568; DOI=10.1073/pnas.0502950102;
RA   Kuroda M., Yamashita A., Hirakawa H., Kumano M., Morikawa K., Higashide M.,
RA   Maruyama A., Inose Y., Matoba K., Toh H., Kuhara S., Hattori M., Ohta T.;
RT   "Whole genome sequence of Staphylococcus saprophyticus reveals the
RT   pathogenesis of uncomplicated urinary tract infection.";
RL   Proc. Natl. Acad. Sci. U.S.A. 102:13272-13277(2005).
CC   -!- FUNCTION: Reduces FMN, organic nitro compounds and disulfide DTNB.
CC       Involved in maintenance of the cellular redox state and the disulfide
CC       stress response (By similarity). {ECO:0000250}.
CC   -!- COFACTOR:
CC       Name=FMN; Xref=ChEBI:CHEBI:58210; Evidence={ECO:0000250};
CC   -!- SIMILARITY: Belongs to the flavin oxidoreductase frp family.
CC       {ECO:0000305}.
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DR   EMBL; AP008934; BAE19476.1; -; Genomic_DNA.
DR   RefSeq; WP_011303929.1; NZ_MTGA01000035.1.
DR   AlphaFoldDB; Q49UU0; -.
DR   SMR; Q49UU0; -.
DR   STRING; 342451.SSP2331; -.
DR   EnsemblBacteria; BAE19476; BAE19476; SSP2331.
DR   KEGG; ssp:SSP2331; -.
DR   PATRIC; fig|342451.11.peg.2320; -.
DR   eggNOG; COG0778; Bacteria.
DR   HOGENOM; CLU_070764_0_0_9; -.
DR   OMA; GMCLGYP; -.
DR   OrthoDB; 1847197at2; -.
DR   Proteomes; UP000006371; Chromosome.
DR   GO; GO:0016491; F:oxidoreductase activity; IEA:UniProtKB-KW.
DR   CDD; cd02146; NfsA-like; 1.
DR   Gene3D; 3.40.109.10; -; 1.
DR   InterPro; IPR016446; Flavin_OxRdtase_Frp.
DR   InterPro; IPR029479; Nitroreductase.
DR   InterPro; IPR000415; Nitroreductase-like.
DR   PANTHER; PTHR43425; PTHR43425; 1.
DR   Pfam; PF00881; Nitroreductase; 1.
DR   PIRSF; PIRSF005426; Frp; 1.
DR   SUPFAM; SSF55469; SSF55469; 1.
PE   3: Inferred from homology;
KW   Flavoprotein; FMN; NADP; Oxidoreductase; Reference proteome.
FT   CHAIN           1..251
FT                   /note="NADPH-dependent oxidoreductase"
FT                   /id="PRO_0000239731"
SQ   SEQUENCE   251 AA;  28612 MW;  CAA07DA88CFAA300 CRC64;
     MSEHVYNLLK NHHSVRKFKK EPISEAHIKQ LVEAGQNAST SSYLQAYSII GINDPEIKEE
     LKEVSGQPYV VENGYLFVFV MDYYRHSIIN EESKHDMQTS FESAEGLLVG TIDATLVAQN
     IAATAEDMGY GMVYLGSLRN DVERVREILE LPKHTFPLFG MALGIPEDDE NGSPKPRLPF
     EHVFHANKYD SDKDSQRETL KAYDQTVSDY YSSRTNGERT ESWSNQVANF MSAKQRLDML
     EQLNKSGFIK K