ID   NFRKB_XENTR             Reviewed;        1265 AA.
AC   Q6P4L9;
DT   21-MAR-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Nuclear factor related to kappa-B-binding protein;
DE   AltName: Full=DNA-binding protein R kappa-B;
GN   Name=nfrkb;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Binds to DNA. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NFRKB family. {ECO:0000305}.
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DR   EMBL; BC063348; AAH63348.1; -; mRNA.
DR   RefSeq; NP_989207.1; NM_203876.1.
DR   AlphaFoldDB; Q6P4L9; -.
DR   SMR; Q6P4L9; -.
DR   STRING; 8364.ENSXETP00000063281; -.
DR   PaxDb; Q6P4L9; -.
DR   GeneID; 394815; -.
DR   KEGG; xtr:394815; -.
DR   CTD; 4798; -.
DR   Xenbase; XB-GENE-6258496; nfrkb.
DR   eggNOG; KOG1927; Eukaryota.
DR   InParanoid; Q6P4L9; -.
DR   OrthoDB; 140291at2759; -.
DR   Proteomes; UP000008143; Chromosome 7.
DR   Proteomes; UP000790000; Unplaced.
DR   GO; GO:0031011; C:Ino80 complex; IEA:InterPro.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0002020; F:protease binding; IBA:GO_Central.
DR   Gene3D; 1.10.10.2430; -; 1.
DR   InterPro; IPR044867; DEUBAD_dom.
DR   InterPro; IPR024867; NFRKB.
DR   InterPro; IPR025220; NFRKB_winged_dom.
DR   InterPro; IPR038106; NFRKB_winged_sf.
DR   PANTHER; PTHR13052; PTHR13052; 1.
DR   Pfam; PF14465; NFRKB_winged; 1.
DR   PROSITE; PS51916; DEUBAD; 1.
PE   2: Evidence at transcript level;
KW   DNA-binding; Nucleus; Reference proteome.
FT   CHAIN           1..1265
FT                   /note="Nuclear factor related to kappa-B-binding protein"
FT                   /id="PRO_0000227809"
FT   DOMAIN          39..156
FT                   /note="DEUBAD"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01264"
FT   REGION          670..693
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          705..738
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1000..1033
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          1234..1265
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        716..732
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1265 AA;  137075 MW;  C8746D8ED2EE958B CRC64;
     MESLDSMLTD PLELGPCVES NGTGIMEECM LGGTRVSLPE DLLEDPDLFF EVVSRDTWKN
     VLSDSQREHL KQFLPVFPDD NANQQEKIIQ SLFRGDNFRF GNPLHIAQKL FRDGHFNPEV
     VKYRQLCLKS QYKRYLTSQQ QYFHKLLKQI LASRKELLDL ARKNGPDQVL KKKPSSLRNT
     PEERETRAQC RYLKILREVK DECGDGTLSS EEEDLSSWLP ESPTHCPSVA VPLRVIPTLS
     TQDMKTADKQ EFTNHDLKLL LRRHREKRKR QSDHPDLITD NLSMNDIMTR VNAGRKGSLA
     ALFDLATMKK RVKEKDDKKK KKLKTIKTEV EDYPDMPDEA DIMPAVLPPE TPQVTLTAVK
     EEPLEDVKPP LPFNEISACF FCLLLDILTM EGPCSLPLLE DKVSDWQSLP ASTLNSWFSV
     APNWCDLVHP ALIYLSGECK VASSSFTPFV EFREKTQQWK CVVSSSDSEK ELVAHFHLWL
     ETKDQIYSKE NEDCIDASTP IPRVRTDYIV RPSSGEEKHV FQEQERHRYI QPHKAFTFRM
     HGFESVVGPV KGVFDKETSL NKAREHSLLR SDRPAYVTIL SLVRDAAARL PNGEGTRAEI
     CELLKDSQFL APDVTSAQVN TVVSGALDRL HYEKDPCVKY DIGRKLWIYL HRDRSEEEFE
     RIHQAQAAAA KAKKALQQKP KPPTKMKSGS KECSLKLCGT PEPAQLSLTE SSMPPTPGTP
     GTPTPPALPS TPMSPSTSAT VNKIVASTIT ETQKSSQSVL LVSSPAMPQL STLLSPAVTS
     QSTSVTPTSG RAATISSSTG VPQVRIVTAT TGVPTTQSAA VVTQPLSPVI SHIRLPVTTT
     PTKALAQTQV VTVPVKNQTT IGASRLGASV TTQGSVTVNT LNSSAGLASK SVVSSPGASG
     PAILQSITGQ SIIKQVALSG QLGVKSQPSS SLPLSSTNFR IQGKDVLRLP PSSITTDAKG
     QTILRITPDM MATLAKSQVT AVKLSQELFS AAPVSTTGKG LLHVTSSPSS PSPPAPSTIK
     LTPEMKPAET SSSSFRLMPA LGISVAEQKG KVVTAGESKP ATTIRIVQGL GVMPPKVSAT
     QSITVSAKPV TVPSSTIVNP VHSASNVSLP TVNSTAVKTA PTGIVVGTGA ATVRQIPVTT
     TQQGKLPARI TVPLSVLSQP MKGKGVVTAP IIKGNLGANI SGLGRNIILT TVPAGTKLIA
     GNKPVSFLTA QQLQQLQQQG QATQVRIQTV PASHLPQGTS PASSKAVSTV VVTTTPTTKP
     TQEPQ