NFX1_CAEEL
ID NFX1_CAEEL Reviewed; 1119 AA.
AC Q18034;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 164.
DE RecName: Full=Transcriptional repressor NF-X1 homolog;
GN Name=nfx-1; Synonyms=tag-182; ORFNames=C16A3.7;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
CC -!- FUNCTION: May play a role in transcription regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NFX1 family. {ECO:0000305}.
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DR EMBL; FO080367; CCD63227.1; -; Genomic_DNA.
DR PIR; A88481; A88481.
DR RefSeq; NP_498394.1; NM_065993.6.
DR AlphaFoldDB; Q18034; -.
DR BioGRID; 41120; 2.
DR DIP; DIP-26775N; -.
DR STRING; 6239.C16A3.7; -.
DR EPD; Q18034; -.
DR PaxDb; Q18034; -.
DR PeptideAtlas; Q18034; -.
DR EnsemblMetazoa; C16A3.7.1; C16A3.7.1; WBGene00007048.
DR GeneID; 175902; -.
DR KEGG; cel:CELE_C16A3.7; -.
DR UCSC; C16A3.7; c. elegans.
DR CTD; 175902; -.
DR WormBase; C16A3.7; CE04007; WBGene00007048; nfx-1.
DR eggNOG; KOG1952; Eukaryota.
DR GeneTree; ENSGT00940000156325; -.
DR HOGENOM; CLU_005714_0_0_1; -.
DR InParanoid; Q18034; -.
DR OMA; WCEKEVD; -.
DR OrthoDB; 299100at2759; -.
DR PhylomeDB; Q18034; -.
DR PRO; PR:Q18034; -.
DR Proteomes; UP000001940; Chromosome III.
DR Bgee; WBGene00007048; Expressed in germ line (C elegans) and 4 other tissues.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR034078; NFX1_fam.
DR InterPro; IPR001374; R3H_dom.
DR InterPro; IPR036867; R3H_dom_sf.
DR InterPro; IPR000967; Znf_NFX1.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12360; PTHR12360; 1.
DR Pfam; PF01424; R3H; 1.
DR Pfam; PF01422; zf-NF-X1; 7.
DR SMART; SM00393; R3H; 1.
DR SMART; SM00438; ZnF_NFX; 10.
DR SUPFAM; SSF82708; SSF82708; 1.
DR PROSITE; PS51061; R3H; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1119
FT /note="Transcriptional repressor NF-X1 homolog"
FT /id="PRO_0000334615"
FT DOMAIN 867..937
FT /note="R3H"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00382"
FT ZN_FING 235..287
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 330..348
FT /note="NF-X1-type 1"
FT ZN_FING 383..402
FT /note="NF-X1-type 2"
FT ZN_FING 439..458
FT /note="NF-X1-type 3"
FT ZN_FING 500..523
FT /note="NF-X1-type 4"
FT ZN_FING 565..584
FT /note="NF-X1-type 5"
FT ZN_FING 592..611
FT /note="NF-X1-type 6"
FT ZN_FING 649..668
FT /note="NF-X1-type 7"
FT ZN_FING 703..726
FT /note="NF-X1-type 8"
FT ZN_FING 735..756
FT /note="NF-X1-type 9"
FT REGION 1..214
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1024..1047
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1078..1119
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..21
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 67..101
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 111..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 194..214
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1119 AA; 125148 MW; 067CF6DF66C45DFE CRC64;
MADTEGTSSS IPTSTNSSRH RASRGRGGRF RQAPRQVGAN TADNLDAAPL MNPRGGHRGG
SGNKRGRGQK EATSASRLQM QPEANFTFNP NAATFNPAQS VLFDPSVPPP TIGASTHSNQ
NSRQQEPSQN RRRRGGQQNT QRRQLEIQEQ RGDSHPQNQS RQNNRNQLNV DRIANQQNKS
VQNPSRNPGN SRRGQGARRR EQKEEPLTEE ETKILADKPL REGLVYLLEN NKYECAICYT
RITTRQGVWS CKTCYHIFHI STGCITDWAR SSRDKEGANT WRCPTCQTEN ETMPYNYYCF
CGRMRNPNFR VGEVPHSCGE TCGGARKFGC PHPCTELCHP GPCIECKLFT TKSCNCGKTK
KSVRCGSDQE VMCETVCGKQ LSCGQHNCER ICHSGDCGEC TVILEQDCFC GKTPKEVSCN
PCAHEKYSCG SECDGMFSCG IHHCTKKCHD KECGECETGA NRIRTCPCGR NTLQSLGVTR
KKCTDMVPTC DSVCDKWLTC GTPGKNHHCR EKCHEGPCPP CNLNTSVICR CGTSKGVIPC
DEYLQIMKTT GEYLCTKRCR KKKSCGMHKC QEVCCIQDEH FCLQMCNKRL SCGIHTCENV
CHAGQCRPCL QASFDEQFCH CGHTVRMPPI PCGARLPVCS QPCVRPHSCD HSVSHKCHGE
QNCPPCTQLT EKMCYGGHRV RKNIPCHIDS VSCGVVCKKP LKCGVHVCQR TCHGEECEKE
GEKCTKKCET IRELCEHPCA LPCHEDSPCE PSPCKASVRI SCECGRIKKD APCCEVDKMI
LSKLEKEEEE KSESDGEEKV VKEGILKRST SFSQLNCMKC DDECKKLERN RKVAEALEVD
TDEYGMNKLA PTISFPCYLK EMVRTNIDFV KSVEKILIDL VIQILSGEAY HDTFRAHLPA
MSIEKRRFVH EYANFFNIAS ESVDSPPKRS IVLTAVRGKS HQPLVLISDL VNYKGALKTP
GPAVIRKDIM DQALSKKEET EGLMKPLRCT EKMVVRREAR PMKEITAPIP LKQQNQFALL
GSDVDSDDEE SNVPTTSNLV SSPPKDWWKD EEEGWQKVQQ KEYVVEVERD MTEDEIEAAK
KLDEGPTWED QCDEDAPATE TSSAIESPAK EEPVAELLE
