NFX1_DICDI
ID NFX1_DICDI Reviewed; 1506 AA.
AC Q54BK0;
DT 20-MAY-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 103.
DE RecName: Full=Transcriptional repressor NF-X1 homolog;
GN Name=nfx1; ORFNames=DDB_G0293590;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: May play a role in transcription regulation. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NFX1 family. {ECO:0000305}.
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DR EMBL; AAFI02000218; EAL60607.1; -; Genomic_DNA.
DR RefSeq; XP_629029.1; XM_629027.1.
DR AlphaFoldDB; Q54BK0; -.
DR STRING; 44689.DDB0220630; -.
DR PaxDb; Q54BK0; -.
DR EnsemblProtists; EAL60607; EAL60607; DDB_G0293590.
DR GeneID; 8629315; -.
DR KEGG; ddi:DDB_G0293590; -.
DR dictyBase; DDB_G0293590; -.
DR eggNOG; KOG1952; Eukaryota.
DR HOGENOM; CLU_248448_0_0_1; -.
DR InParanoid; Q54BK0; -.
DR OMA; CFGVEGT; -.
DR PRO; PR:Q54BK0; -.
DR Proteomes; UP000002195; Chromosome 6.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR GO; GO:0000122; P:negative regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR InterPro; IPR034078; NFX1_fam.
DR InterPro; IPR000967; Znf_NFX1.
DR InterPro; IPR019787; Znf_PHD-finger.
DR InterPro; IPR001841; Znf_RING.
DR PANTHER; PTHR12360; PTHR12360; 2.
DR Pfam; PF01422; zf-NF-X1; 8.
DR SMART; SM00438; ZnF_NFX; 8.
DR PROSITE; PS50089; ZF_RING_2; 1.
PE 3: Inferred from homology;
KW DNA-binding; Metal-binding; Nucleus; Reference proteome; Repeat;
KW Transcription; Transcription regulation; Zinc; Zinc-finger.
FT CHAIN 1..1506
FT /note="Transcriptional repressor NF-X1 homolog"
FT /id="PRO_0000334616"
FT ZN_FING 363..416
FT /note="PHD-type"
FT ZN_FING 366..414
FT /note="RING-type; degenerate"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT ZN_FING 460..478
FT /note="NF-X1-type 1"
FT ZN_FING 515..534
FT /note="NF-X1-type 2"
FT ZN_FING 581..600
FT /note="NF-X1-type 3"
FT ZN_FING 642..661
FT /note="NF-X1-type 4"
FT ZN_FING 739..758
FT /note="NF-X1-type 5"
FT ZN_FING 796..817
FT /note="NF-X1-type 6"
FT ZN_FING 852..868
FT /note="NF-X1-type 7"
FT ZN_FING 1062..1084
FT /note="NF-X1-type 8"
FT REGION 1..123
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..164
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 181..282
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 897..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1021..1040
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1132..1167
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1447..1473
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 189..217
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 218..233
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 251..265
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 266..280
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 897..920
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 934..984
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 985..1002
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1506 AA; 168882 MW; 8D3831244AE69AD2 CRC64;
MEESQNIPPK TQTLNNSENS INNINNNNLT TTTTTTAVGN TNYKNNNRYN NNRYNRNNFN
NYNNNNNNNN NNNNMVTSTT SPPTTTTTTT STTTTATPSS NSNNRRKNYH NNNYNNNNNN
NQLSEDTDEV ILYTPADISA SLKSESAKQQ QQQQQQSLPT QEPTQTLNWQ QELYKLNPKS
KAFVPKPQGS VPFNNTNNNN NNNNNNNNNV PQSPIKDNNR PQRERRERKP KENNTQQPQP
QQPQQPQQPQ PQPQQQQQSQ QQQTVKENNR KKENKLQSKK DIITNNDNIE PIKSKEDISL
ANKFAKNRAK ENLAKTNSIN NSNTANSNKI KGKTKFIFNE NDEKNSEYTP LAIQMITKIQ
ANIYECMVCF ENVGKNAVIW SCSQCFTMFH SSCIKQWSSK SVTTEGKWKC PGCRYNHEVK
PEHFQPACFC GKVKDPQYNP YHLAHSCGEV CGKLRAKSNC PHSCTMLCHP GPCLNCSSLG
DIKDCYCGKT KYRLLCGEVD KGKVCEGKCE KLLSCGNHRC QQQCHSGSCS PCEVVETQKC
YCGKHIDKTK PCGSGSIDTS QSDDDPRFFS CAEKCDRTLD CGNHKCQRTC HKGDCEPCSL
VPDRVDRCNC KQTTLEELGV VRTSCLDPIP VCKKVCSTLL ACKQHSCTDR CHTGPCGSCK
VKVRSICRCG KTTENRQCGV IQQNMSSTSA AAFTCGNVCK ILRSCKRHEC GVKCCPSTSS
SDEAGNHVCT LVCGKQLKCG VHKCQQLCHS GKCYNCYINS YDDLACPCGK TVIQPPVPCG
TKPPMCNHPC TIKRECGHSN EVWEHKCHSG PCPPCTYLVD KMCAGGHQVQ KSVKCSTIDA
SCGRICGKVL SCLSHTCPRI CHSGPCLINN NNVNINKQQP LLPANLIASK NNYQLQQQSK
LPTTTTTTTT TTSTTSTTSP KIIEKDEELI EDDNNNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN EKAEITNECN HDHDHEHEHS DDENSEEEVD LNECNHNHEC
NEEEERIKKE EKEDDEDEDE LFDSLMGNLT CGYLCGIPLK SCEHTCHQAC HPGEPCPTNI
SCKQKVRIYC KCKRRSVETL CCGKDDTRQL ECDEVCEKEE REKQLKEAFY GSHTLDNNPN
NPNNPNNPNN NTTTTTTTTT TTTSSPTNFT VLDPTSIDYQ PNKLQIEALQ LIAKASPKLI
KKIEAIYEDF INSNLLKQTI KYTDSIQLFL LVQMAKFYQM KYREKKPLNY IEFFKKTSYQ
IPSPRLSEMV GINGSSLSSG TISNSLSFSI NNGQSYASIS LSPSEMVAQA QAQAELENQC
PALLFKNLDP SIKTDHLTNL LQEFEGRYKL MWVDDSNCLA IFGDSISFSM ASQIKTMFTY
EIYQDDPSLI DITFGNSVLS TPTSSSGSNS GVSSPLSYLS PLKKSQDTQF FRVSQQMNKF
SFLDTINQNQ NQNNNNNNNN NNNNNSNINI KPTIPLYSTS TANANRMLRR SNENTGENVA
DDWENL
