ID   NFXL1_XENLA             Reviewed;         914 AA.
AC   A0JMY5;
DT   06-MAR-2007, integrated into UniProtKB/Swiss-Prot.
DT   12-DEC-2006, sequence version 1.
DT   03-AUG-2022, entry version 57.
DE   RecName: Full=NF-X1-type zinc finger protein NFXL1;
GN   Name=nfxl1;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Oocyte;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000305}; Single-pass membrane
CC       protein {ECO:0000305}.
CC   -!- SIMILARITY: Belongs to the NFX1 family. {ECO:0000305}.
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DR   EMBL; BC126051; AAI26052.1; -; mRNA.
DR   RefSeq; NP_001090441.1; NM_001096972.1.
DR   AlphaFoldDB; A0JMY5; -.
DR   MaxQB; A0JMY5; -.
DR   PRIDE; A0JMY5; -.
DR   GeneID; 779353; -.
DR   KEGG; xla:779353; -.
DR   CTD; 779353; -.
DR   Xenbase; XB-GENE-964728; nfxl1.L.
DR   OMA; PCPPCAQ; -.
DR   OrthoDB; 299100at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 779353; Expressed in blastula and 19 other tissues.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005634; C:nucleus; IEA:InterPro.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   InterPro; IPR034078; NFX1_fam.
DR   InterPro; IPR000967; Znf_NFX1.
DR   InterPro; IPR001841; Znf_RING.
DR   PANTHER; PTHR12360; PTHR12360; 1.
DR   Pfam; PF01422; zf-NF-X1; 10.
DR   SMART; SM00438; ZnF_NFX; 11.
DR   PROSITE; PS50089; ZF_RING_2; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Membrane; Metal-binding; Reference proteome; Repeat;
KW   Transmembrane; Transmembrane helix; Zinc; Zinc-finger.
FT   CHAIN           1..914
FT                   /note="NF-X1-type zinc finger protein NFXL1"
FT                   /id="PRO_0000278828"
FT   TRANSMEM        892..909
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   ZN_FING         163..224
FT                   /note="RING-type; atypical"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00175"
FT   ZN_FING         269..287
FT                   /note="NF-X1-type 1"
FT   ZN_FING         322..341
FT                   /note="NF-X1-type 2"
FT   ZN_FING         375..394
FT                   /note="NF-X1-type 3"
FT   ZN_FING         428..447
FT                   /note="NF-X1-type 4"
FT   ZN_FING         455..476
FT                   /note="NF-X1-type 5"
FT   ZN_FING         480..499
FT                   /note="NF-X1-type 6"
FT   ZN_FING         507..526
FT                   /note="NF-X1-type 7"
FT   ZN_FING         674..702
FT                   /note="NF-X1-type 8"
FT   ZN_FING         715..733
FT                   /note="NF-X1-type 9"
FT   ZN_FING         777..796
FT                   /note="NF-X1-type 10"
FT   REGION          1..120
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          830..879
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        18..42
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        53..73
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        74..94
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   914 AA;  102146 MW;  FC0B384F2718B2E1 CRC64;
     MDAPWRQAGR GRARGRATSA SGGSSQAPGP VSASNRNASY PRGVPTDGNG VQRPGTGWGN
     STYASASKPV TTENVKRETN EENSKKKFEE IQKANQAAVK KLAEDHYSSS DDEDGDEDAD
     GKQKKILALT FTSYTSQTDG DLSELARTQQ YVNEAFQAGA VTCLICIASV KRNQAVWSCS
     GCFCIFHMPC IQKWAKDSVF LVSSPLTDDD FEKKDYPWPC PKCRYEYKRS ETPCRYYCYC
     GKVEDPPLDP WLVPHSCGQV CEREFKPTCG HKCLLLCHPG PCPPCPKMVT ITCFCQKAKP
     VPRRCSAKEW SCQQPCRKTL MCKQHKCENP CHKGDCLPCP RVSKQKCLCG RNVAQRPCAS
     PTWQCEQVCG KTLPCGNHTC EKICHAGPCG QCPRSGNRLC PCAKSKYTLP CTEDVPTCGD
     SCDKLLECAL HKCSQRCHRG PCETCRQEVE KQCRCGKHTK RMPCHKPYLC ETKCAKVRDC
     QRHQCKRKCC SGNCPGCDQQ CGRSLGCRNH KCPSVCHRGS CYPCPETIDV KCNCSKTVLK
     VPCGRERTTK PPKCKEVCSC PSTCHHEARE RHRCHFGPCP PCRQTCKKIL NRCSHLCPVP
     CHDEALVKQK GLPQPAGPWE QPSEPTFIQT ALPCPPCQVP IPTECLGKHE ISPLPCHAAG
     PFSCKRPCGR PLACGNHTCS RECHKVTDVN GNKERAGVEC AACEEECNKP RPPECPHRCN
     LPCHSDDCPP CVQMIRTKCH CKISNLFIEC TKLSMADAKE KNNLTSCKNQ CPKELPCGHR
     CKEICHQGNC SLNCIQKVKL RCPCRRIKKE MPCNSVREGH ISLECDSVCL DVRKKAAEMK
     AEEENAAVEQ ERRRQQAELE AFENRLKGKR RKNKRKDEVE VQQTAWQKYK KYIMMPVCGI
     ALAVFTLYYT QVDV