NFYA6_ARATH
ID NFYA6_ARATH Reviewed; 308 AA.
AC Q9LVJ7; C0SVB0;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2000, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Nuclear transcription factor Y subunit A-6;
DE Short=AtNF-YA-6;
GN Name=NFYA6; OrderedLocusNames=At3g14020; ORFNames=MDC16.15;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10819329; DOI=10.1093/dnares/7.2.131;
RA Sato S., Nakamura Y., Kaneko T., Katoh T., Asamizu E., Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 3. I. Sequence
RT features of the regions of 4,504,864 bp covered by sixty P1 and TAC
RT clones.";
RL DNA Res. 7:131-135(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA Takagi M.;
RT "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=11250072; DOI=10.1016/s0378-1119(01)00323-7;
RA Gusmaroli G., Tonelli C., Mantovani R.;
RT "Regulation of the CCAAT-binding NF-Y subunits in Arabidopsis thaliana.";
RL Gene 264:173-185(2001).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11867211; DOI=10.1016/s0378-1119(01)00833-2;
RA Gusmaroli G., Tonelli C., Mantovani R.;
RT "Regulation of novel members of the Arabidopsis thaliana CCAAT-binding
RT nuclear factor Y subunits.";
RL Gene 283:41-48(2002).
CC -!- FUNCTION: Stimulates the transcription of various genes by recognizing
CC and binding to a CCAAT motif in promoters. {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and
CC dimerize for NF-YA association and DNA binding (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q9LVJ7; Q8L4B2: NFYC9; NbExp=3; IntAct=EBI-15195195, EBI-2466050;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in flowers and siliques.
CC {ECO:0000269|PubMed:11250072}.
CC -!- SIMILARITY: Belongs to the NFYA/HAP2 subunit family.
CC {ECO:0000255|PROSITE-ProRule:PRU00966}.
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DR EMBL; AB019229; BAB02333.1; -; Genomic_DNA.
DR EMBL; CP002686; AEE75456.1; -; Genomic_DNA.
DR EMBL; CP002686; ANM65529.1; -; Genomic_DNA.
DR EMBL; AB493613; BAH30451.1; -; mRNA.
DR RefSeq; NP_001327488.1; NM_001338098.1.
DR RefSeq; NP_188018.1; NM_112256.3.
DR PDB; 6R2V; X-ray; 2.50 A; A=170-241.
DR PDBsum; 6R2V; -.
DR AlphaFoldDB; Q9LVJ7; -.
DR SMR; Q9LVJ7; -.
DR BioGRID; 5950; 23.
DR IntAct; Q9LVJ7; 21.
DR STRING; 3702.AT3G14020.1; -.
DR PaxDb; Q9LVJ7; -.
DR PRIDE; Q9LVJ7; -.
DR EnsemblPlants; AT3G14020.1; AT3G14020.1; AT3G14020.
DR EnsemblPlants; AT3G14020.2; AT3G14020.2; AT3G14020.
DR GeneID; 820616; -.
DR Gramene; AT3G14020.1; AT3G14020.1; AT3G14020.
DR Gramene; AT3G14020.2; AT3G14020.2; AT3G14020.
DR KEGG; ath:AT3G14020; -.
DR Araport; AT3G14020; -.
DR TAIR; locus:2088232; AT3G14020.
DR eggNOG; KOG1561; Eukaryota.
DR HOGENOM; CLU_058712_2_0_1; -.
DR InParanoid; Q9LVJ7; -.
DR OMA; YHEVANL; -.
DR OrthoDB; 1213009at2759; -.
DR PhylomeDB; Q9LVJ7; -.
DR PRO; PR:Q9LVJ7; -.
DR Proteomes; UP000006548; Chromosome 3.
DR ExpressionAtlas; Q9LVJ7; baseline and differential.
DR Genevisible; Q9LVJ7; AT.
DR GO; GO:0016602; C:CCAAT-binding factor complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0009793; P:embryo development ending in seed dormancy; IMP:TAIR.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0048316; P:seed development; IMP:TAIR.
DR GO; GO:0010262; P:somatic embryogenesis; IMP:TAIR.
DR InterPro; IPR018362; CCAAT-binding_factor_CS.
DR InterPro; IPR001289; NFYA.
DR PANTHER; PTHR12632; PTHR12632; 1.
DR Pfam; PF02045; CBFB_NFYA; 1.
DR PRINTS; PR00616; CCAATSUBUNTB.
DR SMART; SM00521; CBF; 1.
DR PROSITE; PS00686; NFYA_HAP2_1; 1.
DR PROSITE; PS51152; NFYA_HAP2_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Activator; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..308
FT /note="Nuclear transcription factor Y subunit A-6"
FT /id="PRO_0000198776"
FT DNA_BIND 204..229
FT /note="NFYA/HAP2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00966"
FT REGION 53..76
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 174..197
FT /note="Subunit association domain (SAD)"
FT TURN 177..179
FT /evidence="ECO:0007829|PDB:6R2V"
FT HELIX 180..195
FT /evidence="ECO:0007829|PDB:6R2V"
FT HELIX 209..215
FT /evidence="ECO:0007829|PDB:6R2V"
SQ SEQUENCE 308 AA; 34433 MW; B5D56EAEECD2BA45 CRC64;
MQEFHSSKDS LPCPATSWDN SVFTNSNVQG SSSLTDNNTL SLTMEMKQTG FQMQHYDSSS
TQSTGGESYS EVASLSEPTN RYGHNIVVTH LSGYKENPEN PIGSHSISKV SQDSVVLPIE
AASWPLHGNV TPHFNGFLSF PYASQHTVQH PQIRGLVPSR MPLPHNIPEN EPIFVNAKQY
QAILRRRERR AKLEAQNKLI KVRKPYLHES RHLHALKRVR GSGGRFLNTK KHQESNSSLS
PPFLIPPHVF KNSPGKFRQM DISRGGVVSS VSTTSCSDIT GNNNDMFQQN PQFRFSGYPS
NHHVSVLM
