NFYA8_ARATH
ID NFYA8_ARATH Reviewed; 328 AA.
AC Q9LNP6; B3LF92;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 123.
DE RecName: Full=Nuclear transcription factor Y subunit A-8;
DE Short=AtNF-YA-8;
GN Name=NFYA8; OrderedLocusNames=At1g17590; ORFNames=F11A6.14, F1L3.29;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RA De Los Reyes C., Quan R., Chen H., Bautista V.R., Kim C.J., Ecker J.R.;
RT "Arabidopsis ORF clones.";
RL Submitted (JUN-2008) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=11867211; DOI=10.1016/s0378-1119(01)00833-2;
RA Gusmaroli G., Tonelli C., Mantovani R.;
RT "Regulation of novel members of the Arabidopsis thaliana CCAAT-binding
RT nuclear factor Y subunits.";
RL Gene 283:41-48(2002).
CC -!- FUNCTION: Stimulates the transcription of various genes by recognizing
CC and binding to a CCAAT motif in promoters. {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and
CC dimerize for NF-YA association and DNA binding (By similarity).
CC {ECO:0000250}.
CC -!- INTERACTION:
CC Q9LNP6; Q8L4B2: NFYC9; NbExp=3; IntAct=EBI-15192013, EBI-2466050;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the whole plant, except roots.
CC {ECO:0000269|PubMed:11867211}.
CC -!- SIMILARITY: Belongs to the NFYA/HAP2 subunit family.
CC {ECO:0000255|PROSITE-ProRule:PRU00966}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF79478.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AC022492; AAF79478.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC034257; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; CP002684; AEE29608.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29609.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29610.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE29611.1; -; Genomic_DNA.
DR EMBL; BT033080; ACE98541.1; -; mRNA.
DR RefSeq; NP_001185024.1; NM_001198095.1.
DR RefSeq; NP_173202.1; NM_101621.3.
DR RefSeq; NP_973850.1; NM_202121.2.
DR RefSeq; NP_973851.1; NM_202122.2.
DR AlphaFoldDB; Q9LNP6; -.
DR SMR; Q9LNP6; -.
DR BioGRID; 23575; 25.
DR IntAct; Q9LNP6; 21.
DR STRING; 3702.AT1G17590.3; -.
DR PaxDb; Q9LNP6; -.
DR PRIDE; Q9LNP6; -.
DR ProteomicsDB; 251110; -.
DR EnsemblPlants; AT1G17590.1; AT1G17590.1; AT1G17590.
DR EnsemblPlants; AT1G17590.2; AT1G17590.2; AT1G17590.
DR EnsemblPlants; AT1G17590.3; AT1G17590.3; AT1G17590.
DR EnsemblPlants; AT1G17590.4; AT1G17590.4; AT1G17590.
DR GeneID; 838335; -.
DR Gramene; AT1G17590.1; AT1G17590.1; AT1G17590.
DR Gramene; AT1G17590.2; AT1G17590.2; AT1G17590.
DR Gramene; AT1G17590.3; AT1G17590.3; AT1G17590.
DR Gramene; AT1G17590.4; AT1G17590.4; AT1G17590.
DR KEGG; ath:AT1G17590; -.
DR Araport; AT1G17590; -.
DR TAIR; locus:2007953; AT1G17590.
DR eggNOG; KOG1561; Eukaryota.
DR HOGENOM; CLU_058712_2_0_1; -.
DR InParanoid; Q9LNP6; -.
DR OMA; FACVSYP; -.
DR OrthoDB; 1213009at2759; -.
DR PhylomeDB; Q9LNP6; -.
DR PRO; PR:Q9LNP6; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9LNP6; baseline and differential.
DR Genevisible; Q9LNP6; AT.
DR GO; GO:0016602; C:CCAAT-binding factor complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR018362; CCAAT-binding_factor_CS.
DR InterPro; IPR001289; NFYA.
DR PANTHER; PTHR12632; PTHR12632; 1.
DR Pfam; PF02045; CBFB_NFYA; 1.
DR PRINTS; PR00616; CCAATSUBUNTB.
DR SMART; SM00521; CBF; 1.
DR PROSITE; PS00686; NFYA_HAP2_1; 1.
DR PROSITE; PS51152; NFYA_HAP2_2; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..328
FT /note="Nuclear transcription factor Y subunit A-8"
FT /id="PRO_0000198778"
FT DNA_BIND 205..230
FT /note="NFYA/HAP2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00966"
FT REGION 54..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 175..198
FT /note="Subunit association domain (SAD)"
SQ SEQUENCE 328 AA; 36463 MW; 1B04241E2F22F1A7 CRC64;
MDKKVSFTSS VAHSTPPYLS TSISWGLPTK SNGVTESLSL KVVDARPERL INTKNISFQD
QDSSSTLSSA QSSNDVTSSG DDNPSRQISF LAHSDVCKGF EETQRKRFAI KSGSSTAGIA
DIHSSPSKAN FSFHYADPHF GGLMPAAYLP QATIWNPQMT RVPLPFDLIE NEPVFVNAKQ
FHAIMRRRQQ RAKLEAQNKL IKARKPYLHE SRHVHALKRP RGSGGRFLNT KKLQESTDPK
QDMPIQQQHA TGNMSRFVLY QLQNSNDCDC STTSRSDITS ASDSVNLFGH SEFLISDCPS
QTNPTMYVHG QSNDMHGGRN THHFSVHI
