NFYAA_ARATH
ID NFYAA_ARATH Reviewed; 269 AA.
AC Q8LFU0; Q9FG19;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 2.
DT 25-MAY-2022, entry version 114.
DE RecName: Full=Nuclear transcription factor Y subunit A-10;
DE Short=AtNF-YA-10;
GN Name=NFYA10; OrderedLocusNames=At5g06510; ORFNames=F15M7.4;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RA Kaneko T., Katoh T., Asamizu E., Sato S., Nakamura Y., Kotani H.,
RA Tabata S.;
RT "Structural analysis of Arabidopsis thaliana chromosome 5. XI.";
RL Submitted (JUN-2000) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11867211; DOI=10.1016/s0378-1119(01)00833-2;
RA Gusmaroli G., Tonelli C., Mantovani R.;
RT "Regulation of novel members of the Arabidopsis thaliana CCAAT-binding
RT nuclear factor Y subunits.";
RL Gene 283:41-48(2002).
CC -!- FUNCTION: Stimulates the transcription of various genes by recognizing
CC and binding to a CCAAT motif in promoters. {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and
CC dimerize for NF-YA association and DNA binding (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q8LFU0-1; Sequence=Displayed;
CC -!- SIMILARITY: Belongs to the NFYA/HAP2 subunit family.
CC {ECO:0000255|PROSITE-ProRule:PRU00966}.
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DR EMBL; AP002543; BAB11400.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91025.1; -; Genomic_DNA.
DR EMBL; CP002688; AED91027.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68856.1; -; Genomic_DNA.
DR EMBL; CP002688; ANM68857.1; -; Genomic_DNA.
DR EMBL; AY084643; AAM61206.1; -; mRNA.
DR RefSeq; NP_001330575.1; NM_001342881.1. [Q8LFU0-1]
DR RefSeq; NP_001330576.1; NM_001342882.1. [Q8LFU0-1]
DR RefSeq; NP_196269.1; NM_120734.4. [Q8LFU0-1]
DR RefSeq; NP_974741.1; NM_203012.1. [Q8LFU0-1]
DR AlphaFoldDB; Q8LFU0; -.
DR SMR; Q8LFU0; -.
DR BioGRID; 15818; 5.
DR STRING; 3702.AT5G06510.2; -.
DR PaxDb; Q8LFU0; -.
DR ProteomicsDB; 250509; -. [Q8LFU0-1]
DR EnsemblPlants; AT5G06510.1; AT5G06510.1; AT5G06510. [Q8LFU0-1]
DR EnsemblPlants; AT5G06510.2; AT5G06510.2; AT5G06510. [Q8LFU0-1]
DR EnsemblPlants; AT5G06510.5; AT5G06510.5; AT5G06510. [Q8LFU0-1]
DR EnsemblPlants; AT5G06510.6; AT5G06510.6; AT5G06510. [Q8LFU0-1]
DR GeneID; 830539; -.
DR Gramene; AT5G06510.1; AT5G06510.1; AT5G06510. [Q8LFU0-1]
DR Gramene; AT5G06510.2; AT5G06510.2; AT5G06510. [Q8LFU0-1]
DR Gramene; AT5G06510.5; AT5G06510.5; AT5G06510. [Q8LFU0-1]
DR Gramene; AT5G06510.6; AT5G06510.6; AT5G06510. [Q8LFU0-1]
DR KEGG; ath:AT5G06510; -.
DR Araport; AT5G06510; -.
DR TAIR; locus:2144113; AT5G06510.
DR eggNOG; KOG1561; Eukaryota.
DR InParanoid; Q8LFU0; -.
DR OMA; TPWWNAF; -.
DR PhylomeDB; Q8LFU0; -.
DR PRO; PR:Q8LFU0; -.
DR Proteomes; UP000006548; Chromosome 5.
DR ExpressionAtlas; Q8LFU0; baseline and differential.
DR Genevisible; Q8LFU0; AT.
DR GO; GO:0016602; C:CCAAT-binding factor complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR InterPro; IPR018362; CCAAT-binding_factor_CS.
DR InterPro; IPR001289; NFYA.
DR PANTHER; PTHR12632; PTHR12632; 1.
DR Pfam; PF02045; CBFB_NFYA; 1.
DR SMART; SM00521; CBF; 1.
DR PROSITE; PS00686; NFYA_HAP2_1; 1.
DR PROSITE; PS51152; NFYA_HAP2_2; 1.
PE 2: Evidence at transcript level;
KW Activator; Alternative splicing; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..269
FT /note="Nuclear transcription factor Y subunit A-10"
FT /id="PRO_0000198780"
FT DNA_BIND 164..189
FT /note="NFYA/HAP2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00966"
FT REGION 168..227
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 137..158
FT /note="Subunit association domain (SAD)"
FT COMPBIAS 191..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 66
FT /note="G -> R (in Ref. 3; AAM61206)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 269 AA; 29794 MW; 13A1A3F240192386 CRC64;
MQTEELLSPP QTPWWNAFGS QPLTTESLSG EASDSFTGVK AVTTEAEQGV VDKQTSTTLF
TFSPGGEKSS RDVPKPHVAF AMQSACFEFG FAQPMMYTKH PHVEQYYGVV SAYGSQRSSG
RVMIPLKMET EEDGTIYVNS KQYHGIIRRR QSRAKAEKLS RCRKPYMHHS RHLHAMRRPR
GSGGRFLNTK TADAAKQSKP SNSQSSEVFH PENETINSSR EANESNLSDS AVTSMDYFLS
SSAYSPGGMV MPIKWNAAAM DIGCCKLNI
