NFYA_DICDI
ID NFYA_DICDI Reviewed; 517 AA.
AC Q54S29;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 82.
DE RecName: Full=Nuclear transcription factor Y subunit alpha;
DE AltName: Full=CAAT box DNA-binding protein subunit A;
DE AltName: Full=Nuclear transcription factor Y subunit A;
DE Short=NF-YA;
GN Name=nfyA; ORFNames=DDB_G0282697;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the NF-Y/HAP transcription factor complex. The
CC NF-Y complex stimulates the transcription of various genes by
CC recognizing and binding to a CCAAT motif in promoters (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC components, nfyA, nfyB and nfyC. nfyB and nfyC must interact and
CC dimerize for nfyA association and DNA binding (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00966}.
CC -!- SIMILARITY: Belongs to the NFYA/HAP2 subunit family.
CC {ECO:0000255|PROSITE-ProRule:PRU00966}.
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DR EMBL; AAFI02000047; EAL66208.1; -; Genomic_DNA.
DR RefSeq; XP_640210.1; XM_635118.1.
DR AlphaFoldDB; Q54S29; -.
DR SMR; Q54S29; -.
DR STRING; 44689.DDB0220100; -.
DR PaxDb; Q54S29; -.
DR EnsemblProtists; EAL66208; EAL66208; DDB_G0282697.
DR GeneID; 8623750; -.
DR KEGG; ddi:DDB_G0282697; -.
DR dictyBase; DDB_G0282697; nfyA.
DR eggNOG; KOG1561; Eukaryota.
DR HOGENOM; CLU_527271_0_0_1; -.
DR InParanoid; Q54S29; -.
DR OMA; NRRWQSE; -.
DR PRO; PR:Q54S29; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016602; C:CCAAT-binding factor complex; ISS:dictyBase.
DR GO; GO:0003677; F:DNA binding; ISS:dictyBase.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:dictyBase.
DR InterPro; IPR018362; CCAAT-binding_factor_CS.
DR InterPro; IPR001289; NFYA.
DR PANTHER; PTHR12632; PTHR12632; 1.
DR Pfam; PF02045; CBFB_NFYA; 1.
DR PRINTS; PR00616; CCAATSUBUNTB.
DR SMART; SM00521; CBF; 1.
DR PROSITE; PS00686; NFYA_HAP2_1; 1.
DR PROSITE; PS51152; NFYA_HAP2_2; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..517
FT /note="Nuclear transcription factor Y subunit alpha"
FT /id="PRO_0000371334"
FT DNA_BIND 262..287
FT /note="NFYA/HAP2-type"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00966"
FT REGION 1..95
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 121..183
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 252..281
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..517
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOTIF 232..255
FT /note="Subunit association domain (SAD)"
FT COMPBIAS 21..95
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 304..358
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 372..517
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 517 AA; 57279 MW; 01E6625A0C00BFF9 CRC64;
MNQINYLTSE RNFLPPTDRD ILNLGNNSSN SNNNSSSSNN NNNNNNNNNN NNNNNNNNSN
SNSNSNNNNN NNSNNNNSSS SPDHMSLHSN GMDIHHNQQN HHYQNIQHQP HHFQQNYDER
RIDYGNNNNN NNTNSMNNSN NNSNNNSNNN SNNNNNNNNN NNNNNNNNNS NNNNNSNNNN
FNYNIKQQPQ QTLQNQIVNM NGNIITSNGN HHYPTPHMLY ARMAEIVEEP LYVNAKQYNR
ILKRRAARAK LESENKLPKT RKAYQHESRH QHAIRRQRGC GGRFLTKADQ AKLDAQNAAN
AAAAAANPNA SSTSTTTSNI TNNNNNNNNN NNTNNNNNNN NTNVNGSGGS GGSNKIASSD
DDIENDVEND SDSANIKNNS NSPNQSSSSP PPSKSKVVKK SNTINKRNNN INNNNNNNNN
NNNEKTQPIS SSSSSSSPLL NNGHIQAQQN QSPSSSPSQN LPPLNFSNNI NNNINNNGNP
TNFNNNNPNN NPNNNNNNNP NNNSFLPPLS NFSNNRS
