ID   NFYB_CHICK              Reviewed;         205 AA.
AC   P25207; Q5ZL45;
DT   01-MAY-1992, integrated into UniProtKB/Swiss-Prot.
DT   30-AUG-2005, sequence version 2.
DT   03-AUG-2022, entry version 142.
DE   RecName: Full=Nuclear transcription factor Y subunit beta;
DE   AltName: Full=CAAT box DNA-binding protein subunit B;
DE   AltName: Full=Nuclear transcription factor Y subunit B;
DE            Short=NF-YB;
GN   Name=NFYB; ORFNames=RCJMB04_7n24;
OS   Gallus gallus (Chicken).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae;
OC   Phasianinae; Gallus.
OX   NCBI_TaxID=9031;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=CB; TISSUE=Bursa of Fabricius;
RX   PubMed=15642098; DOI=10.1186/gb-2004-6-1-r6;
RA   Caldwell R.B., Kierzek A.M., Arakawa H., Bezzubov Y., Zaim J., Fiedler P.,
RA   Kutter S., Blagodatski A., Kostovska D., Koter M., Plachy J., Carninci P.,
RA   Hayashizaki Y., Buerstedde J.-M.;
RT   "Full-length cDNAs from chicken bursal lymphocytes to facilitate gene
RT   function analysis.";
RL   Genome Biol. 6:R6.1-R6.9(2005).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 1-151.
RX   PubMed=1549471; DOI=10.1093/nar/20.5.1087;
RA   Li X.-Y., Mantovani R., Hooft van Huijsduijnen R., Andre I., Benoist C.,
RA   Mathis D.;
RT   "Evolutionary variation of the CCAAT-binding transcription factor NF-Y.";
RL   Nucleic Acids Res. 20:1087-1091(1992).
CC   -!- FUNCTION: Component of the sequence-specific heterotrimeric
CC       transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3'
CC       box motif found in the promoters of its target genes. NF-Y can function
CC       as both an activator and a repressor, depending on its interacting
CC       cofactors.
CC   -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC       components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and
CC       dimerize for NF-YA association and DNA binding (By similarity).
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus.
CC   -!- DOMAIN: Can be divided into 3 domains: the weakly conserved A domain,
CC       the highly conserved B domain thought to be involved in subunit
CC       interaction and DNA binding, and the Glu-rich C domain.
CC   -!- SIMILARITY: Belongs to the NFYB/HAP3 subunit family. {ECO:0000305}.
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DR   EMBL; AJ719889; CAG31548.1; -; mRNA.
DR   EMBL; X59713; CAA42233.1; ALT_SEQ; mRNA.
DR   PIR; S24469; S24469.
DR   RefSeq; NP_990600.1; NM_205269.1.
DR   AlphaFoldDB; P25207; -.
DR   SMR; P25207; -.
DR   STRING; 9031.ENSGALP00000020733; -.
DR   PaxDb; P25207; -.
DR   Ensembl; ENSGALT00000054743; ENSGALP00000057619; ENSGALG00000041193.
DR   Ensembl; ENSGALT00000065187; ENSGALP00000051245; ENSGALG00000041193.
DR   Ensembl; ENSGALT00000067128; ENSGALP00000050636; ENSGALG00000041193.
DR   Ensembl; ENSGALT00000070018; ENSGALP00000056991; ENSGALG00000041193.
DR   Ensembl; ENSGALT00000101106; ENSGALP00000072563; ENSGALG00000041193.
DR   GeneID; 396205; -.
DR   KEGG; gga:396205; -.
DR   CTD; 4801; -.
DR   VEuPathDB; HostDB:geneid_396205; -.
DR   eggNOG; KOG0869; Eukaryota.
DR   GeneTree; ENSGT00940000154917; -.
DR   HOGENOM; CLU_066247_9_2_1; -.
DR   InParanoid; P25207; -.
DR   OMA; PRWDWFL; -.
DR   OrthoDB; 1529111at2759; -.
DR   PhylomeDB; P25207; -.
DR   TreeFam; TF314521; -.
DR   PRO; PR:P25207; -.
DR   Proteomes; UP000000539; Chromosome 1.
DR   Bgee; ENSGALG00000041193; Expressed in spermatocyte and 12 other tissues.
DR   ExpressionAtlas; P25207; baseline and differential.
DR   GO; GO:0016602; C:CCAAT-binding factor complex; IBA:GO_Central.
DR   GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:InterPro.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR   GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   Gene3D; 1.10.20.10; -; 1.
DR   InterPro; IPR003958; CBFA_NFYB_domain.
DR   InterPro; IPR009072; Histone-fold.
DR   InterPro; IPR027113; Transc_fact_NFYB/HAP3.
DR   InterPro; IPR003956; Transcrpt_fac_NFYB/HAP3_CS.
DR   PANTHER; PTHR11064; PTHR11064; 1.
DR   Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR   SUPFAM; SSF47113; SSF47113; 1.
DR   PROSITE; PS00685; NFYB_HAP3; 1.
PE   2: Evidence at transcript level;
KW   Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..205
FT                   /note="Nuclear transcription factor Y subunit beta"
FT                   /id="PRO_0000204612"
FT   DNA_BIND        57..63
FT                   /evidence="ECO:0000250"
FT   REGION          1..50
FT                   /note="A domain"
FT   REGION          24..50
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          51..140
FT                   /note="B domain"
FT   REGION          84..95
FT                   /note="Subunit association domain (SAD)"
FT                   /evidence="ECO:0000250"
FT   REGION          141..201
FT                   /note="C domain"
FT   COMPBIAS        28..49
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   205 AA;  22585 MW;  C68BEBBE27049AD2 CRC64;
     MDGDSSTTDA SQLGIAGDYI GGSHYVIQPH DDTEDSMNDH EDTNGSKESF REQDIYLPIA
     NVARIMKNAI PQTGKIAKDA KECVQECVSE FISFITSEAS ERCHQEKRKT INGEDILFAM
     STLGFDSYVE PLKLYLQKFR EAMKGEKGIG GTVTTGDGLS EELTEEAFTN QLPAGLITTD
     GQQQNVMVYT TSYQQISGVQ QIQFS