NFYB_DICDI
ID NFYB_DICDI Reviewed; 490 AA.
AC Q54WV0;
DT 05-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 102.
DE RecName: Full=Nuclear transcription factor Y subunit beta;
DE AltName: Full=CAAT box DNA-binding protein subunit B;
DE AltName: Full=Nuclear transcription factor Y subunit B;
DE Short=NF-YB;
GN Name=nfyB; ORFNames=DDB_G0279419;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Component of the NF-Y/HAP transcription factor complex. The
CC NF-Y complex stimulates the transcription of various genes by
CC recognizing and binding to a CCAAT motif in promoters (By similarity).
CC {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC components, nfyA, nfyB and nfyC. nfyB and nfyC must interact and
CC dimerize for nfyA association and DNA binding (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NFYB/HAP3 subunit family. {ECO:0000305}.
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DR EMBL; AAFI02000031; EAL67648.1; -; Genomic_DNA.
DR RefSeq; XP_641617.1; XM_636525.1.
DR AlphaFoldDB; Q54WV0; -.
DR SMR; Q54WV0; -.
DR STRING; 44689.DDB0220099; -.
DR PaxDb; Q54WV0; -.
DR EnsemblProtists; EAL67648; EAL67648; DDB_G0279419.
DR GeneID; 8622023; -.
DR KEGG; ddi:DDB_G0279419; -.
DR dictyBase; DDB_G0279419; nfyB.
DR eggNOG; KOG0869; Eukaryota.
DR HOGENOM; CLU_557158_0_0_1; -.
DR InParanoid; Q54WV0; -.
DR OMA; CACIICT; -.
DR PRO; PR:Q54WV0; -.
DR Proteomes; UP000002195; Chromosome 3.
DR GO; GO:0016602; C:CCAAT-binding factor complex; ISS:dictyBase.
DR GO; GO:0003677; F:DNA binding; ISS:dictyBase.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IEA:InterPro.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IEA:InterPro.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:dictyBase.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR003958; CBFA_NFYB_domain.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR027113; Transc_fact_NFYB/HAP3.
DR InterPro; IPR003956; Transcrpt_fac_NFYB/HAP3_CS.
DR PANTHER; PTHR11064; PTHR11064; 1.
DR Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
DR PROSITE; PS00685; NFYB_HAP3; 1.
PE 3: Inferred from homology;
KW Activator; Coiled coil; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..490
FT /note="Nuclear transcription factor Y subunit beta"
FT /id="PRO_0000371333"
FT DNA_BIND 53..59
FT /evidence="ECO:0000250"
FT REGION 1..48
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 80..91
FT /note="Subunit association domain (SAD)"
FT /evidence="ECO:0000250"
FT REGION 139..195
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 221..264
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..490
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 188..219
FT /evidence="ECO:0000255"
FT COILED 269..307
FT /evidence="ECO:0000255"
FT COMPBIAS 1..43
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 156..171
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 490 AA; 56677 MW; CEB1C25530B84333 CRC64;
MSGNEDFIYD DNSSSSISNQ TDGGGGGGSS NNNSGGNANN NNNEGDREQD RYLPIANIIR
IMKKALPNNA KVAKDAKETV QDCVSEFISF ITSEASDKCQ QEKRKTINGE DIIAAMVSLG
FENYVEPLKV YLLKYRETEK NSNNKRSPKK SESSSPPESP PLAHLDNSIN SGYQPPPPPQ
QQQQQPPQVQ QQQQQQQQQQ QQQLQQQQQL QQHQQQQLQP QQQQQHLQQH LQQQQPQQQQ
QPPQQQQQQL TTTTTTTSTN NQQYQQQPQQ QQQQQQQQQQ QQQQQQQQQQ QQQQQQQQQQ
QQQQQVQPPY ILQQHNIQQP NVFLNQQAQQ QQQQQQQQQQ PMMNIQSHQQ QFPQQHQIQQ
HLQQQHQHLQ QIHNMQPPHQ QMQFNQQFQM SQQIQMPQQF SNNNNNNNNN NNNNNNNNNN
NNSNNNNNNN NNNNNNNNNP NNNINNNLNN SSNSLHNSGN SLHNSGNSGQ IPPLYQQPYI
STNPEYPSTS
