NFYC2_ARATH
ID NFYC2_ARATH Reviewed; 199 AA.
AC Q8LCG7; O23636; Q8VY66; Q9SGU4;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 20-DEC-2005, sequence version 2.
DT 03-AUG-2022, entry version 133.
DE RecName: Full=Nuclear transcription factor Y subunit C-2;
DE Short=AtNF-YC-2;
DE AltName: Full=Transcriptional activator HAP5B;
GN Name=NFYC2; Synonyms=HAP5B; OrderedLocusNames=At1g56170;
GN ORFNames=F14G9.21, T6H22.3;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [5]
RP NUCLEOTIDE SEQUENCE [MRNA] OF 59-199, AND TISSUE SPECIFICITY.
RX PubMed=9662544; DOI=10.1104/pp.117.3.1015;
RA Edwards D., Murray J.A.H., Smith A.G.;
RT "Multiple genes encoding the conserved CCAAT-box transcription factor
RT complex are expressed in Arabidopsis.";
RL Plant Physiol. 117:1015-1022(1998).
RN [6]
RP TISSUE SPECIFICITY.
RX PubMed=11250072; DOI=10.1016/s0378-1119(01)00323-7;
RA Gusmaroli G., Tonelli C., Mantovani R.;
RT "Regulation of the CCAAT-binding NF-Y subunits in Arabidopsis thaliana.";
RL Gene 264:173-185(2001).
RN [7]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11867211; DOI=10.1016/s0378-1119(01)00833-2;
RA Gusmaroli G., Tonelli C., Mantovani R.;
RT "Regulation of novel members of the Arabidopsis thaliana CCAAT-binding
RT nuclear factor Y subunits.";
RL Gene 283:41-48(2002).
RN [8]
RP INTERACTION WITH HTT1, AND SUBCELLULAR LOCATION.
RC STRAIN=cv. Columbia, and cv. Wassilewskija;
RX PubMed=24728648; DOI=10.1105/tpc.114.124883;
RA Li S., Liu J., Liu Z., Li X., Wu F., He Y.;
RT "HEAT-INDUCED TAS1 TARGET1 Mediates Thermotolerance via HEAT STRESS
RT TRANSCRIPTION FACTOR A1a-Directed Pathways in Arabidopsis.";
RL Plant Cell 26:1764-1780(2014).
CC -!- FUNCTION: Stimulates the transcription of various genes by recognizing
CC and binding to a CCAAT motif in promoters. {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and
CC dimerize for NF-YA association and DNA binding (By similarity).
CC Interacts with HTT1 in both cytoplasm and nucleus (PubMed:24728648).
CC {ECO:0000250, ECO:0000269|PubMed:24728648}.
CC -!- INTERACTION:
CC Q8LCG7; Q8L500: APRR9; NbExp=3; IntAct=EBI-2125983, EBI-7920168;
CC Q8LCG7; Q9LRH6: GATA25; NbExp=3; IntAct=EBI-2125983, EBI-2460434;
CC Q8LCG7; Q7XA73: TIFY4A; NbExp=3; IntAct=EBI-2125983, EBI-15199673;
CC Q8LCG7; Q8GY55: TIFY4B; NbExp=3; IntAct=EBI-2125983, EBI-15206004;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000269|PubMed:24728648}. Cytoplasm
CC {ECO:0000269|PubMed:24728648}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. {ECO:0000269|PubMed:11250072,
CC ECO:0000269|PubMed:9662544}.
CC -!- SIMILARITY: Belongs to the NFYC/HAP5 subunit family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF02832.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=AAG50900.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC Sequence=CAA74053.1; Type=Erroneous termination; Note=Truncated C-terminus.; Evidence={ECO:0000305};
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DR EMBL; AC009894; AAF02832.1; ALT_INIT; Genomic_DNA.
DR EMBL; AC069159; AAG50900.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE33353.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE33354.1; -; Genomic_DNA.
DR EMBL; AY072411; AAL62403.1; -; mRNA.
DR EMBL; AY114704; AAM48023.1; -; mRNA.
DR EMBL; AY086605; AAM63665.1; -; mRNA.
DR EMBL; Y13725; CAA74053.1; ALT_SEQ; mRNA.
DR PIR; B96603; B96603.
DR RefSeq; NP_001077726.1; NM_001084257.2.
DR RefSeq; NP_176013.1; NM_104496.3.
DR AlphaFoldDB; Q8LCG7; -.
DR SMR; Q8LCG7; -.
DR BioGRID; 27295; 22.
DR IntAct; Q8LCG7; 6.
DR STRING; 3702.AT1G56170.2; -.
DR PaxDb; Q8LCG7; -.
DR PRIDE; Q8LCG7; -.
DR ProteomicsDB; 251056; -.
DR EnsemblPlants; AT1G56170.1; AT1G56170.1; AT1G56170.
DR EnsemblPlants; AT1G56170.2; AT1G56170.2; AT1G56170.
DR GeneID; 842070; -.
DR Gramene; AT1G56170.1; AT1G56170.1; AT1G56170.
DR Gramene; AT1G56170.2; AT1G56170.2; AT1G56170.
DR KEGG; ath:AT1G56170; -.
DR Araport; AT1G56170; -.
DR TAIR; locus:2011776; AT1G56170.
DR eggNOG; KOG1657; Eukaryota.
DR HOGENOM; CLU_045277_5_4_1; -.
DR InParanoid; Q8LCG7; -.
DR OMA; PPRAYQS; -.
DR PhylomeDB; Q8LCG7; -.
DR PRO; PR:Q8LCG7; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8LCG7; differential.
DR Genevisible; Q8LCG7; AT.
DR GO; GO:0016602; C:CCAAT-binding factor complex; ISS:TAIR.
DR GO; GO:0005737; C:cytoplasm; IDA:UniProtKB.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISS:TAIR.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR Pfam; PF00125; Histone; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW Activator; Cytoplasm; DNA-binding; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..199
FT /note="Nuclear transcription factor Y subunit C-2"
FT /id="PRO_0000218251"
FT CONFLICT 53
FT /note="Q -> K (in Ref. 4; AAM63665)"
FT /evidence="ECO:0000305"
FT CONFLICT 145
FT /note="Missing (in Ref. 4; AAM63665)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 199 AA; 23124 MW; 38A0E251F5555DA2 CRC64;
MEQSEEGQQQ QQQGVMDYVP PHAYQSGPVN AASHMAFQQA HHFHHHHQQQ QQQQLQMFWA
NQMQEIEHTT DFKNHTLPLA RIKKIMKADE DVRMISAEAP VIFAKACEMF ILELTLRAWI
HTEENKRRTL QKNDIAAAIS RTDVFDFLVD IIPRDELKEE GLGVTKGTIP SVVGSPPYYY
LQQQGMMQHW PQEQHPDES
