NFYC9_ARATH
ID NFYC9_ARATH Reviewed; 231 AA.
AC Q8L4B2; O04033; Q9SNZ0;
DT 20-DEC-2005, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-2002, sequence version 1.
DT 25-MAY-2022, entry version 131.
DE RecName: Full=Nuclear transcription factor Y subunit C-9;
DE Short=AtNF-YC-9;
DE AltName: Full=Transcriptional activator HAP5C;
GN Name=NFYC9; Synonyms=HAP5C; OrderedLocusNames=At1g08970; ORFNames=F7G19.16;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Gherraby W., Pateraki I., Makris A.M., Sanmartin M., Chatzopoulos P.,
RA Kanellis A.K.;
RT "Manipulation of the expression of heme activated protein HAP5c gene in
RT transgenic plants.";
RL Submitted (OCT-1999) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RA Brover V.V., Troukhan M.E., Alexandrov N.A., Lu Y.-P., Flavell R.B.,
RA Feldmann K.A.;
RT "Full-length cDNA from Arabidopsis thaliana.";
RL Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
RN [6]
RP GENE FAMILY, NOMENCLATURE, AND TISSUE SPECIFICITY.
RX PubMed=11867211; DOI=10.1016/s0378-1119(01)00833-2;
RA Gusmaroli G., Tonelli C., Mantovani R.;
RT "Regulation of novel members of the Arabidopsis thaliana CCAAT-binding
RT nuclear factor Y subunits.";
RL Gene 283:41-48(2002).
RN [7]
RP TISSUE SPECIFICITY.
RC STRAIN=cv. Columbia, and cv. Wassilewskija;
RX PubMed=17322342; DOI=10.1104/pp.106.089904;
RA Warpeha K.M., Upadhyay S., Yeh J., Adamiak J., Hawkins S.I., Lapik Y.R.,
RA Anderson M.B., Kaufman L.S.;
RT "The GCR1, GPA1, PRN1, NF-Y signal chain mediates both blue light and
RT abscisic acid responses in Arabidopsis.";
RL Plant Physiol. 143:1590-1600(2007).
RN [8]
RP FUNCTION, AND INTERACTION WITH NFYA2; NFYB2; REF6; CO AND RGA.
RX PubMed=25105952; DOI=10.1038/ncomms5601;
RA Hou X., Zhou J., Liu C., Liu L., Shen L., Yu H.;
RT "Nuclear factor Y-mediated H3K27me3 demethylation of the SOC1 locus
RT orchestrates flowering responses of Arabidopsis.";
RL Nat. Commun. 5:4601-4601(2014).
CC -!- FUNCTION: Stimulates the transcription of various genes by recognizing
CC and binding to a CCAAT motif in promoters (By similarity). Interacts
CC with REF6 to directly regulate SOC1 transcription in response to
CC flowering signals from photoperiod and gibberellic acid pathways
CC (PubMed:25105952). {ECO:0000250, ECO:0000269|PubMed:25105952}.
CC -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC components, NF-YA, NF-YB and NF-YC. Interacts with NFYA2, NFYB2, CO and
CC RGA. Interacts with REF6 (via N-terminus).
CC {ECO:0000269|PubMed:25105952}.
CC -!- INTERACTION:
CC Q8L4B2; Q9LKL2: APRR1; NbExp=3; IntAct=EBI-2466050, EBI-618423;
CC Q8L4B2; A0A178U8Q1: AXX17_At5g59430; NbExp=3; IntAct=EBI-2466050, EBI-15192959;
CC Q8L4B2; Q39057: CO; NbExp=3; IntAct=EBI-2466050, EBI-1639724;
CC Q8L4B2; O50055: COL1; NbExp=3; IntAct=EBI-2466050, EBI-1112154;
CC Q8L4B2; O22800-2: COL14; NbExp=3; IntAct=EBI-2466050, EBI-15192033;
CC Q8L4B2; Q9C7E8: COL15; NbExp=3; IntAct=EBI-2466050, EBI-2465998;
CC Q8L4B2; Q8H1G0: GATA28; NbExp=3; IntAct=EBI-2466050, EBI-4435064;
CC Q8L4B2; P94077: LSD1; NbExp=4; IntAct=EBI-2466050, EBI-5849461;
CC Q8L4B2; Q8VY64: NFYA4; NbExp=4; IntAct=EBI-2466050, EBI-4461713;
CC Q8L4B2; Q9LVJ7: NFYA6; NbExp=3; IntAct=EBI-2466050, EBI-15195195;
CC Q8L4B2; Q9LNP6: NFYA8; NbExp=3; IntAct=EBI-2466050, EBI-15192013;
CC Q8L4B2; Q945M9: NFYA9; NbExp=3; IntAct=EBI-2466050, EBI-15191941;
CC Q8L4B2; Q9SLG0: NFYB1; NbExp=3; IntAct=EBI-2466050, EBI-2126009;
CC Q8L4B2; Q67XJ2: NFYB10; NbExp=3; IntAct=EBI-2466050, EBI-2475824;
CC Q8L4B2; Q9FGJ3: NFYB2; NbExp=5; IntAct=EBI-2466050, EBI-15192505;
CC Q8L4B2; O23310: NFYB3; NbExp=3; IntAct=EBI-2466050, EBI-4452064;
CC Q8L4B2; O04027: NFYB4; NbExp=3; IntAct=EBI-2466050, EBI-1751677;
CC Q8L4B2; O82248: NFYB5; NbExp=3; IntAct=EBI-2466050, EBI-2475759;
CC Q8L4B2; Q84W66-2: NFYB6; NbExp=3; IntAct=EBI-2466050, EBI-15191739;
CC Q8L4B2; Q9SIT9: NFYB7; NbExp=3; IntAct=EBI-2466050, EBI-4459822;
CC Q8L4B2; Q8VYK4: NFYB8; NbExp=3; IntAct=EBI-2466050, EBI-15192579;
CC Q8L4B2; Q9LQF0: TCP23; NbExp=4; IntAct=EBI-2466050, EBI-15192297;
CC Q8L4B2; Q8LPR5: TCP4; NbExp=3; IntAct=EBI-2466050, EBI-15192325;
CC Q8L4B2; Q9FME3: TCP5; NbExp=3; IntAct=EBI-2466050, EBI-15192251;
CC Q8L4B2; Q8GY55: TIFY4B; NbExp=3; IntAct=EBI-2466050, EBI-15206004;
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- TISSUE SPECIFICITY: Ubiquitous. Present in etiolated seedlings.
CC {ECO:0000269|PubMed:11867211, ECO:0000269|PubMed:17322342}.
CC -!- SIMILARITY: Belongs to the NFYC/HAP5 subunit family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB70410.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AF193440; AAF06791.1; -; mRNA.
DR EMBL; AC000106; AAB70410.1; ALT_INIT; Genomic_DNA.
DR EMBL; CP002684; AEE28374.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28375.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28376.1; -; Genomic_DNA.
DR EMBL; CP002684; AEE28377.1; -; Genomic_DNA.
DR EMBL; AY126997; AAM83224.1; -; mRNA.
DR EMBL; AY143827; AAN28766.1; -; mRNA.
DR EMBL; AY085860; AAM63073.1; -; mRNA.
DR PIR; E86221; E86221.
DR RefSeq; NP_172371.1; NM_100768.4.
DR RefSeq; NP_849619.1; NM_179288.3.
DR RefSeq; NP_973796.1; NM_202067.2.
DR RefSeq; NP_973797.1; NM_202068.2.
DR AlphaFoldDB; Q8L4B2; -.
DR SMR; Q8L4B2; -.
DR BioGRID; 22658; 80.
DR IntAct; Q8L4B2; 70.
DR STRING; 3702.AT1G08970.4; -.
DR iPTMnet; Q8L4B2; -.
DR PaxDb; Q8L4B2; -.
DR PRIDE; Q8L4B2; -.
DR ProteomicsDB; 251105; -.
DR EnsemblPlants; AT1G08970.1; AT1G08970.1; AT1G08970.
DR EnsemblPlants; AT1G08970.2; AT1G08970.2; AT1G08970.
DR EnsemblPlants; AT1G08970.3; AT1G08970.3; AT1G08970.
DR EnsemblPlants; AT1G08970.4; AT1G08970.4; AT1G08970.
DR GeneID; 837417; -.
DR Gramene; AT1G08970.1; AT1G08970.1; AT1G08970.
DR Gramene; AT1G08970.2; AT1G08970.2; AT1G08970.
DR Gramene; AT1G08970.3; AT1G08970.3; AT1G08970.
DR Gramene; AT1G08970.4; AT1G08970.4; AT1G08970.
DR KEGG; ath:AT1G08970; -.
DR Araport; AT1G08970; -.
DR TAIR; locus:2036034; AT1G08970.
DR eggNOG; KOG1657; Eukaryota.
DR HOGENOM; CLU_045277_0_0_1; -.
DR InParanoid; Q8L4B2; -.
DR OMA; HAHASTY; -.
DR OrthoDB; 1558176at2759; -.
DR PhylomeDB; Q8L4B2; -.
DR PRO; PR:Q8L4B2; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q8L4B2; baseline and differential.
DR Genevisible; Q8L4B2; AT.
DR GO; GO:0005737; C:cytoplasm; HDA:TAIR.
DR GO; GO:0005576; C:extracellular region; HDA:TAIR.
DR GO; GO:0005634; C:nucleus; HDA:TAIR.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0043565; F:sequence-specific DNA binding; IDA:TAIR.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IPI:TAIR.
DR GO; GO:0009738; P:abscisic acid-activated signaling pathway; IGI:TAIR.
DR GO; GO:0009740; P:gibberellic acid mediated signaling pathway; IGI:TAIR.
DR GO; GO:2000306; P:positive regulation of photomorphogenesis; IMP:TAIR.
DR GO; GO:0010029; P:regulation of seed germination; IGI:TAIR.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR003958; CBFA_NFYB_domain.
DR InterPro; IPR009072; Histone-fold.
DR Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..231
FT /note="Nuclear transcription factor Y subunit C-9"
FT /id="PRO_0000218258"
FT REGION 211..231
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 215..231
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CONFLICT 78
FT /note="N -> K (in Ref. 1; AAF06791)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 231 AA; 25640 MW; 997477FDB1E2C1AF CRC64;
MDQQDHGQSG AMNYGTNPYQ TNPMSTTAAT VAGGAAQPGQ LAFHQIHQQQ QQQQLAQQLQ
AFWENQFKEI EKTTDFKNHS LPLARIKKIM KADEDVRMIS AEAPVVFARA CEMFILELTL
RSWNHTEENK RRTLQKNDIA AAVTRTDIFD FLVDIVPRED LRDEVLGSIP RGTVPEAAAA
GYPYGYLPAG TAPIGNPGMV MGNPGGAYPP NPYMGQPMWQ QQAPDQPDQE N
