NFYC_BOVIN
ID NFYC_BOVIN Reviewed; 335 AA.
AC Q5E9X1; Q5EA27;
DT 08-NOV-2005, integrated into UniProtKB/Swiss-Prot.
DT 15-MAR-2005, sequence version 1.
DT 03-AUG-2022, entry version 113.
DE RecName: Full=Nuclear transcription factor Y subunit gamma;
DE AltName: Full=CAAT box DNA-binding protein subunit C;
DE AltName: Full=Nuclear transcription factor Y subunit C;
DE Short=NF-YC;
GN Name=NFYC;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=16305752; DOI=10.1186/1471-2164-6-166;
RA Harhay G.P., Sonstegard T.S., Keele J.W., Heaton M.P., Clawson M.L.,
RA Snelling W.M., Wiedmann R.T., Van Tassell C.P., Smith T.P.L.;
RT "Characterization of 954 bovine full-CDS cDNA sequences.";
RL BMC Genomics 6:166-166(2005).
CC -!- FUNCTION: Component of the sequence-specific heterotrimeric
CC transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3'
CC box motif found in the promoters of its target genes. NF-Y can function
CC as both an activator and a repressor, depending on its interacting
CC cofactors (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and
CC dimerize for NF-YA association and DNA binding (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NFYC/HAP5 subunit family. {ECO:0000305}.
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DR EMBL; BT020742; AAX08759.1; -; mRNA.
DR EMBL; BT020799; AAX08816.1; -; mRNA.
DR RefSeq; NP_001029770.1; NM_001034598.1.
DR RefSeq; XP_005204835.1; XM_005204778.2.
DR RefSeq; XP_005204836.1; XM_005204779.3.
DR RefSeq; XP_010801959.1; XM_010803657.2.
DR RefSeq; XP_010801960.1; XM_010803658.2.
DR RefSeq; XP_010801961.1; XM_010803659.2.
DR RefSeq; XP_010801962.1; XM_010803660.2.
DR RefSeq; XP_010801963.1; XM_010803661.1.
DR RefSeq; XP_010801964.1; XM_010803662.2.
DR RefSeq; XP_010801965.1; XM_010803663.1.
DR AlphaFoldDB; Q5E9X1; -.
DR SMR; Q5E9X1; -.
DR STRING; 9913.ENSBTAP00000029254; -.
DR PaxDb; Q5E9X1; -.
DR Ensembl; ENSBTAT00000074351; ENSBTAP00000057952; ENSBTAG00000021943.
DR Ensembl; ENSBTAT00000081656; ENSBTAP00000067634; ENSBTAG00000021943.
DR GeneID; 534003; -.
DR KEGG; bta:534003; -.
DR CTD; 4802; -.
DR VEuPathDB; HostDB:ENSBTAG00000021943; -.
DR VGNC; VGNC:32057; NFYC.
DR eggNOG; KOG1657; Eukaryota.
DR GeneTree; ENSGT00940000155689; -.
DR HOGENOM; CLU_045277_2_1_1; -.
DR InParanoid; Q5E9X1; -.
DR OMA; DIAQPMF; -.
DR OrthoDB; 1558176at2759; -.
DR TreeFam; TF354207; -.
DR Proteomes; UP000009136; Chromosome 3.
DR Bgee; ENSBTAG00000021943; Expressed in retina and 106 other tissues.
DR ExpressionAtlas; Q5E9X1; baseline.
DR GO; GO:0016602; C:CCAAT-binding factor complex; IBA:GO_Central.
DR GO; GO:0005654; C:nucleoplasm; IEA:Ensembl.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0032993; C:protein-DNA complex; IEA:Ensembl.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IEA:Ensembl.
DR GO; GO:0080182; P:histone H3-K4 trimethylation; IEA:Ensembl.
DR GO; GO:0035065; P:regulation of histone acetylation; IEA:Ensembl.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR Pfam; PF00125; Histone; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..335
FT /note="Nuclear transcription factor Y subunit gamma"
FT /id="PRO_0000218245"
FT CONFLICT 297
FT /note="Missing (in Ref. 1; AAX08759)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 335 AA; 37134 MW; 33AD21FF5E73E423 CRC64;
MSTEGGFGGA GSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM
ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR
DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ QPTAVQVQGQ QQGQQTTSST TTIQPGQIII
AQPQQGQTTP VTMQVGEGQQ VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP
VQLNAGQLQY IRLAQPVSGT QVVQGQIQTL ATNAQQITQT EVQQGQQQFS QFTDGQQLYQ
IQQVTMPAGQ DLAQPMFIQS ANQPSDGQAP QVTGD
