NFYC_DICDI
ID NFYC_DICDI Reviewed; 684 AA.
AC Q557I1; Q8SSZ4;
DT 08-APR-2008, integrated into UniProtKB/Swiss-Prot.
DT 24-MAY-2005, sequence version 1.
DT 25-MAY-2022, entry version 121.
DE RecName: Full=Nuclear transcription factor Y subunit gamma;
DE AltName: Full=Nuclear transcription factor Y subunit C;
DE Short=NF-YC;
GN Name=nfyc-1; ORFNames=DDB_G0273479;
GN and
GN Name=nfyc-2; ORFNames=DDB_G0273545;
OS Dictyostelium discoideum (Slime mold).
OC Eukaryota; Amoebozoa; Evosea; Eumycetozoa; Dictyostelia; Dictyosteliales;
OC Dictyosteliaceae; Dictyostelium.
OX NCBI_TaxID=44689;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=12097910; DOI=10.1038/nature00847;
RA Gloeckner G., Eichinger L., Szafranski K., Pachebat J.A., Bankier A.T.,
RA Dear P.H., Lehmann R., Baumgart C., Parra G., Abril J.F., Guigo R.,
RA Kumpf K., Tunggal B., Cox E.C., Quail M.A., Platzer M., Rosenthal A.,
RA Noegel A.A.;
RT "Sequence and analysis of chromosome 2 of Dictyostelium discoideum.";
RL Nature 418:79-85(2002).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=AX4;
RX PubMed=15875012; DOI=10.1038/nature03481;
RA Eichinger L., Pachebat J.A., Gloeckner G., Rajandream M.A., Sucgang R.,
RA Berriman M., Song J., Olsen R., Szafranski K., Xu Q., Tunggal B.,
RA Kummerfeld S., Madera M., Konfortov B.A., Rivero F., Bankier A.T.,
RA Lehmann R., Hamlin N., Davies R., Gaudet P., Fey P., Pilcher K., Chen G.,
RA Saunders D., Sodergren E.J., Davis P., Kerhornou A., Nie X., Hall N.,
RA Anjard C., Hemphill L., Bason N., Farbrother P., Desany B., Just E.,
RA Morio T., Rost R., Churcher C.M., Cooper J., Haydock S., van Driessche N.,
RA Cronin A., Goodhead I., Muzny D.M., Mourier T., Pain A., Lu M., Harper D.,
RA Lindsay R., Hauser H., James K.D., Quiles M., Madan Babu M., Saito T.,
RA Buchrieser C., Wardroper A., Felder M., Thangavelu M., Johnson D.,
RA Knights A., Loulseged H., Mungall K.L., Oliver K., Price C., Quail M.A.,
RA Urushihara H., Hernandez J., Rabbinowitsch E., Steffen D., Sanders M.,
RA Ma J., Kohara Y., Sharp S., Simmonds M.N., Spiegler S., Tivey A.,
RA Sugano S., White B., Walker D., Woodward J.R., Winckler T., Tanaka Y.,
RA Shaulsky G., Schleicher M., Weinstock G.M., Rosenthal A., Cox E.C.,
RA Chisholm R.L., Gibbs R.A., Loomis W.F., Platzer M., Kay R.R.,
RA Williams J.G., Dear P.H., Noegel A.A., Barrell B.G., Kuspa A.;
RT "The genome of the social amoeba Dictyostelium discoideum.";
RL Nature 435:43-57(2005).
CC -!- FUNCTION: Stimulates the transcription of various genes by recognizing
CC and binding to a CCAAT motif in promoters. {ECO:0000250}.
CC -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and
CC dimerize for NF-YA association and DNA binding (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NFYC/HAP5 subunit family. {ECO:0000305}.
CC -!- CAUTION: The gene for this protein is duplicated in strains AX3 and
CC AX4. These strains contain a duplication of a segment of 750 kb of
CC chromosome 2 compared to the corresponding sequence in strain AX2.
CC {ECO:0000305}.
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DR EMBL; AAFI02000010; EAL70694.1; -; Genomic_DNA.
DR EMBL; AAFI02000010; EAL70727.1; -; Genomic_DNA.
DR RefSeq; XP_644597.1; XM_639505.1.
DR RefSeq; XP_644654.1; XM_639562.1.
DR AlphaFoldDB; Q557I1; -.
DR SMR; Q557I1; -.
DR STRING; 44689.DDB0220097; -.
DR PaxDb; Q557I1; -.
DR EnsemblProtists; EAL70694; EAL70694; DDB_G0273479.
DR EnsemblProtists; EAL70727; EAL70727; DDB_G0273545.
DR GeneID; 8618961; -.
DR GeneID; 8619016; -.
DR KEGG; ddi:DDB_G0273479; -.
DR KEGG; ddi:DDB_G0273545; -.
DR dictyBase; DDB_G0273479; nfyC-1.
DR dictyBase; DDB_G0273545; nfyC-2.
DR eggNOG; KOG1657; Eukaryota.
DR HOGENOM; CLU_402509_0_0_1; -.
DR InParanoid; Q557I1; -.
DR OMA; SMENCES; -.
DR PRO; PR:Q557I1; -.
DR Proteomes; UP000002195; Chromosome 2.
DR GO; GO:0016602; C:CCAAT-binding factor complex; ISS:dictyBase.
DR GO; GO:0005634; C:nucleus; IBA:GO_Central.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; IBA:GO_Central.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR003958; CBFA_NFYB_domain.
DR InterPro; IPR009072; Histone-fold.
DR Pfam; PF00808; CBFD_NFYB_HMF; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 3: Inferred from homology;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..684
FT /note="Nuclear transcription factor Y subunit gamma"
FT /id="PRO_0000328559"
FT REGION 1..74
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 112..238
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 414..487
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 511..650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..50
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 112..163
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..210
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 221..238
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 511..643
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 684 AA; 78054 MW; B188B6FC8DF5975A CRC64;
MENQIHSLLH FPSSASTGST SNSHNNHHNN NNNNNYNNNN NNNINNINNN HHHHHNYKSI
QQHSPHSSTP NISTENVDIY SSHEANSSNG YNNGNNFSYS MNGNFNYNFS PMNSPHHSHN
HPDTSNNNML PLNDSGIHFN QHQHPSSASS SSSSSSSSLS SSSHHHHSNH HHHHPNLHIN
LPPIPQYPSL NDSSSNGNGT PALSSPSSTT PHPTTPHPTT PTSTPNQRFQ SNGSSSFQNQ
LQNHLENKLS SFWSSQLRDI HKTEDFKTHE LPLARIKKIM KSDKDVNKIS SEAPILFAKA
CEILILEMTH RSWVHTEMNK RRTLQRTDII NSLSRCETFD FLIDMLPRDE IKPSRKYLDE
LSKAQVITPE YLQYLQLQQM ATENQQKNNQ NNQNNQNKNN QQILPQQRNL NIPHSPQLQE
QSSNNNNNNN NNNNNNNSVS VKRSYSMEIQ NSSPLSTPKK RSNSQDYNFQ YNENNHNQSS
LSQTQQLQQL NQQQQQQQQQ QQQQQQQQQQ QQQQHSQQIS QQIHHIPTPS NSSSSLPPLP
PHNSNHAHNN NNNNNNNNNN NNNNNLNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN
NNNNNNNNNN NNNNNNNNNN NNNNNNNNNN NNNNNNNTFD YSFNDSKNDE HKVSLNESNF
ISTPTNDNII SSSPSSQVYY YSDN
