NFYC_MOUSE
ID NFYC_MOUSE Reviewed; 335 AA.
AC P70353; O35088; Q6GU21;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 08-NOV-2005, sequence version 2.
DT 03-AUG-2022, entry version 173.
DE RecName: Full=Nuclear transcription factor Y subunit gamma;
DE AltName: Full=CAAT box DNA-binding protein subunit C;
DE AltName: Full=Nuclear transcription factor Y subunit C;
DE Short=NF-YC;
GN Name=Nfyc;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=8910521; DOI=10.1074/jbc.271.46.28784;
RA Nakshatri H., Bhat-Nakshatri P., Currie R.A.;
RT "Subunit association and DNA binding activity of the heterotrimeric
RT transcription factor NF-Y is regulated by cellular redox.";
RL J. Biol. Chem. 271:28784-28791(1996).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=9287329; DOI=10.1074/jbc.272.37.23216;
RA Orita T., Shimozaki K., Murakami H., Nagata S.;
RT "Binding of NF-Y transcription factor to one of the Cis-elements in the
RT myeloperoxidase gene promoter that responds to granulocyte colony-
RT stimulating factor.";
RL J. Biol. Chem. 272:23216-23223(1997).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=Czech II, and FVB/N; TISSUE=Colon, and Mammary tumor;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4]
RP IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
RC TISSUE=Lung, and Spleen;
RX PubMed=21183079; DOI=10.1016/j.cell.2010.12.001;
RA Huttlin E.L., Jedrychowski M.P., Elias J.E., Goswami T., Rad R.,
RA Beausoleil S.A., Villen J., Haas W., Sowa M.E., Gygi S.P.;
RT "A tissue-specific atlas of mouse protein phosphorylation and expression.";
RL Cell 143:1174-1189(2010).
CC -!- FUNCTION: Component of the sequence-specific heterotrimeric
CC transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3'
CC box motif found in the promoters of its target genes. NF-Y can function
CC as both an activator and a repressor, depending on its interacting
CC cofactors.
CC -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and
CC dimerize for NF-YA association and DNA binding (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the NFYC/HAP5 subunit family. {ECO:0000305}.
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DR EMBL; U62297; AAC52892.1; -; mRNA.
DR EMBL; AB006181; BAA22216.1; -; mRNA.
DR EMBL; BC020117; AAH20117.1; -; mRNA.
DR EMBL; BC085261; AAH85261.1; -; mRNA.
DR CCDS; CCDS18594.1; -.
DR RefSeq; NP_001041633.1; NM_001048168.2.
DR RefSeq; NP_001264024.1; NM_001277095.1.
DR RefSeq; NP_032718.2; NM_008692.4.
DR RefSeq; XP_006502909.1; XM_006502846.1.
DR RefSeq; XP_017175513.1; XM_017320024.1.
DR RefSeq; XP_017175514.1; XM_017320025.1.
DR AlphaFoldDB; P70353; -.
DR SMR; P70353; -.
DR BioGRID; 201762; 24.
DR ComplexPortal; CPX-89; CCAAT-binding factor complex.
DR IntAct; P70353; 22.
DR STRING; 10090.ENSMUSP00000112810; -.
DR PhosphoSitePlus; P70353; -.
DR EPD; P70353; -.
DR MaxQB; P70353; -.
DR PaxDb; P70353; -.
DR PeptideAtlas; P70353; -.
DR PRIDE; P70353; -.
DR ProteomicsDB; 252832; -.
DR Antibodypedia; 18017; 260 antibodies from 29 providers.
DR DNASU; 18046; -.
DR Ensembl; ENSMUST00000043429; ENSMUSP00000047441; ENSMUSG00000032897.
DR Ensembl; ENSMUST00000097906; ENSMUSP00000095516; ENSMUSG00000032897.
DR Ensembl; ENSMUST00000118902; ENSMUSP00000112610; ENSMUSG00000032897.
DR Ensembl; ENSMUST00000120779; ENSMUSP00000112810; ENSMUSG00000032897.
DR GeneID; 18046; -.
DR KEGG; mmu:18046; -.
DR UCSC; uc008unn.2; mouse.
DR CTD; 4802; -.
DR MGI; MGI:107901; Nfyc.
DR VEuPathDB; HostDB:ENSMUSG00000032897; -.
DR eggNOG; KOG1657; Eukaryota.
DR GeneTree; ENSGT00940000155689; -.
DR HOGENOM; CLU_045277_2_1_1; -.
DR InParanoid; P70353; -.
DR OMA; DIAQPMF; -.
DR OrthoDB; 1558176at2759; -.
DR PhylomeDB; P70353; -.
DR TreeFam; TF354207; -.
DR BioGRID-ORCS; 18046; 24 hits in 79 CRISPR screens.
DR ChiTaRS; Nfyc; mouse.
DR PRO; PR:P70353; -.
DR Proteomes; UP000000589; Chromosome 4.
DR RNAct; P70353; protein.
DR Bgee; ENSMUSG00000032897; Expressed in secondary oocyte and 73 other tissues.
DR ExpressionAtlas; P70353; baseline and differential.
DR Genevisible; P70353; MM.
DR GO; GO:0016602; C:CCAAT-binding factor complex; ISO:MGI.
DR GO; GO:0005654; C:nucleoplasm; ISO:MGI.
DR GO; GO:0005634; C:nucleus; IDA:MGI.
DR GO; GO:0032993; C:protein-DNA complex; ISO:MGI.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; ISO:MGI.
DR GO; GO:0005667; C:transcription regulator complex; IC:MGI.
DR GO; GO:0003677; F:DNA binding; IDA:MGI.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; IDA:NTNU_SB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IDA:MGI.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; IDA:NTNU_SB.
DR GO; GO:0000976; F:transcription cis-regulatory region binding; IDA:MGI.
DR GO; GO:0080182; P:histone H3-K4 trimethylation; ISO:MGI.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; IDA:NTNU_SB.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; IDA:MGI.
DR GO; GO:0035065; P:regulation of histone acetylation; ISO:MGI.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:MGI.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR Pfam; PF00125; Histone; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 1: Evidence at protein level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..335
FT /note="Nuclear transcription factor Y subunit gamma"
FT /id="PRO_0000218247"
FT CONFLICT 72
FT /note="A -> G (in Ref. 1; AAC52892)"
FT /evidence="ECO:0000305"
FT CONFLICT 87
FT /note="H -> R (in Ref. 1; AAC52892)"
FT /evidence="ECO:0000305"
FT CONFLICT 95
FT /note="T -> P (in Ref. 1; AAC52892)"
FT /evidence="ECO:0000305"
FT CONFLICT 163
FT /note="G -> P (in Ref. 1; AAC52892)"
FT /evidence="ECO:0000305"
FT CONFLICT 236
FT /note="I -> T (in Ref. 1; AAC52892)"
FT /evidence="ECO:0000305"
FT CONFLICT 246
FT /note="G -> A (in Ref. 1; AAC52892)"
FT /evidence="ECO:0000305"
FT CONFLICT 287
FT /note="Q -> E (in Ref. 1; AAC52892)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 335 AA; 37254 MW; D14620C1773C31E5 CRC64;
MSTEGGFGGT SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM
ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR
DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ QPTAVQVQGQ QQGQQTTSST TTIQPGQIII
AQPQQGQTTP VTMQVGEGQQ VQIVQAQPQG QAQQTQSGTG QTMQVMQQII TNTGEIQQIP
VQLNAGQLQY IRLAQPVSGT QVVQGQIQTL ATNAQQITQT EVQQGQQQFS QFTDGQQLYQ
IQQVTMPAGQ DLAQPMFIQS ANQPSDGQTP QVTGD
