NFYC_RAT
ID NFYC_RAT Reviewed; 335 AA.
AC Q62725; Q566C6;
DT 23-JAN-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1996, sequence version 1.
DT 03-AUG-2022, entry version 146.
DE RecName: Full=Nuclear transcription factor Y subunit gamma;
DE AltName: Full=CAAT box DNA-binding protein subunit C;
DE AltName: Full=CCAAT-binding transcription factor subunit C;
DE Short=CBF-C;
DE AltName: Full=Nuclear transcription factor Y subunit C;
DE Short=NF-YC;
GN Name=Nfyc;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley; TISSUE=Brain;
RX PubMed=7878029; DOI=10.1073/pnas.92.5.1624;
RA Sinha S., Maity S.N., Lu J., de Crombrugghe B.;
RT "Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a
RT protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3.";
RL Proc. Natl. Acad. Sci. U.S.A. 92:1624-1628(1995).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
CC -!- FUNCTION: Component of the sequence-specific heterotrimeric
CC transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3'
CC box motif found in the promoters of its target genes. NF-Y can function
CC as both an activator and a repressor, depending on its interacting
CC cofactors.
CC -!- SUBUNIT: Heterotrimeric transcription factor composed of three
CC components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and
CC dimerize for NF-YA association and DNA binding (By similarity).
CC {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Nucleus.
CC -!- SIMILARITY: Belongs to the NFYC/HAP5 subunit family. {ECO:0000305}.
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DR EMBL; U17607; AAA91103.1; -; mRNA.
DR EMBL; BC093619; AAH93619.1; -; mRNA.
DR PIR; I59348; I59348.
DR RefSeq; NP_036998.1; NM_012866.2.
DR RefSeq; XP_006238847.1; XM_006238785.3.
DR RefSeq; XP_017448648.1; XM_017593159.1.
DR AlphaFoldDB; Q62725; -.
DR SMR; Q62725; -.
DR BioGRID; 247376; 1.
DR DIP; DIP-2662N; -.
DR STRING; 10116.ENSRNOP00000053489; -.
DR PaxDb; Q62725; -.
DR Ensembl; ENSRNOT00000056651; ENSRNOP00000053489; ENSRNOG00000010735.
DR GeneID; 25337; -.
DR KEGG; rno:25337; -.
DR UCSC; RGD:3173; rat.
DR CTD; 4802; -.
DR RGD; 3173; Nfyc.
DR eggNOG; KOG1657; Eukaryota.
DR GeneTree; ENSGT00940000155689; -.
DR HOGENOM; CLU_045277_2_1_1; -.
DR InParanoid; Q62725; -.
DR OMA; DIAQPMF; -.
DR OrthoDB; 1558176at2759; -.
DR PhylomeDB; Q62725; -.
DR TreeFam; TF354207; -.
DR PRO; PR:Q62725; -.
DR Proteomes; UP000002494; Chromosome 5.
DR Bgee; ENSRNOG00000010735; Expressed in thymus and 20 other tissues.
DR Genevisible; Q62725; RN.
DR GO; GO:0016602; C:CCAAT-binding factor complex; IDA:RGD.
DR GO; GO:0005654; C:nucleoplasm; TAS:Reactome.
DR GO; GO:0005634; C:nucleus; ISO:RGD.
DR GO; GO:0032993; C:protein-DNA complex; ISO:RGD.
DR GO; GO:0090575; C:RNA polymerase II transcription regulator complex; ISO:RGD.
DR GO; GO:0003677; F:DNA binding; ISO:RGD.
DR GO; GO:0001228; F:DNA-binding transcription activator activity, RNA polymerase II-specific; ISO:RGD.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; ISO:RGD.
DR GO; GO:0046982; F:protein heterodimerization activity; IEA:InterPro.
DR GO; GO:0000978; F:RNA polymerase II cis-regulatory region sequence-specific DNA binding; ISO:RGD.
DR GO; GO:0080182; P:histone H3-K4 trimethylation; ISO:RGD.
DR GO; GO:0045944; P:positive regulation of transcription by RNA polymerase II; ISO:RGD.
DR GO; GO:0045893; P:positive regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0035065; P:regulation of histone acetylation; ISO:RGD.
DR GO; GO:0006355; P:regulation of transcription, DNA-templated; ISO:RGD.
DR GO; GO:0006366; P:transcription by RNA polymerase II; IC:RGD.
DR Gene3D; 1.10.20.10; -; 1.
DR InterPro; IPR009072; Histone-fold.
DR InterPro; IPR007125; Histone_H2A/H2B/H3.
DR Pfam; PF00125; Histone; 1.
DR SUPFAM; SSF47113; SSF47113; 1.
PE 2: Evidence at transcript level;
KW Activator; DNA-binding; Nucleus; Reference proteome; Transcription;
KW Transcription regulation.
FT CHAIN 1..335
FT /note="Nuclear transcription factor Y subunit gamma"
FT /id="PRO_0000218249"
SQ SEQUENCE 335 AA; 37254 MW; CD663F057DF7B6A6 CRC64;
MSTEGGFGST SSSDAQQSLQ SFWPRVMEEI RNLTVKDFRV QELPLARIKK IMKLDEDVKM
ISAEAPVLFA KAAQIFITEL TLRAWIHTED NKRRTLQRND IAMAITKFDQ FDFLIDIVPR
DELKPPKRQE EVRQSVTPAE PVQYYFTLAQ QPTAVQVQGQ QQGQQTTSST TTIQPGQIII
AQPQQGQTTP VTMQVGEGQQ VQIVQAQPQG QAQQAQSGTG QTMQVMQQII TNTGEIQQIP
VQLNAGQLQY IRLAQPVSGT QVVQGQIQTL ATNAQQITQT EVQQGQQQFS QFTDGQQLYQ
IQQVTMPAGQ DLAQPMFIQS ANQPSDGQTP QVTGD
