ID   NGA4_ARATH              Reviewed;         333 AA.
AC   O82595; C3VMM5;
DT   26-MAY-2009, integrated into UniProtKB/Swiss-Prot.
DT   31-MAY-2011, sequence version 2.
DT   03-AUG-2022, entry version 119.
DE   RecName: Full=B3 domain-containing transcription factor NGA4;
DE   AltName: Full=Protein NGATHA 4;
GN   Name=NGA4; OrderedLocusNames=At4g01500; ORFNames=F11O4.9;
OS   Arabidopsis thaliana (Mouse-ear cress).
OC   Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC   Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC   rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX   NCBI_TaxID=3702;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=cv. Landsberg erecta;
RA   Alvarez J.P., Goldshmidt A., Efroni I., Bowman J.L., Eshed Y.;
RT   "The NGATHA distal organ development genes are essential for style
RT   specification in Arabidopsis.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=cv. Columbia;
RX   PubMed=10617198; DOI=10.1038/47134;
RA   Mayer K.F.X., Schueller C., Wambutt R., Murphy G., Volckaert G., Pohl T.,
RA   Duesterhoeft A., Stiekema W., Entian K.-D., Terryn N., Harris B.,
RA   Ansorge W., Brandt P., Grivell L.A., Rieger M., Weichselgartner M.,
RA   de Simone V., Obermaier B., Mache R., Mueller M., Kreis M., Delseny M.,
RA   Puigdomenech P., Watson M., Schmidtheini T., Reichert B., Portetelle D.,
RA   Perez-Alonso M., Boutry M., Bancroft I., Vos P., Hoheisel J.,
RA   Zimmermann W., Wedler H., Ridley P., Langham S.-A., McCullagh B.,
RA   Bilham L., Robben J., van der Schueren J., Grymonprez B., Chuang Y.-J.,
RA   Vandenbussche F., Braeken M., Weltjens I., Voet M., Bastiaens I., Aert R.,
RA   Defoor E., Weitzenegger T., Bothe G., Ramsperger U., Hilbert H., Braun M.,
RA   Holzer E., Brandt A., Peters S., van Staveren M., Dirkse W., Mooijman P.,
RA   Klein Lankhorst R., Rose M., Hauf J., Koetter P., Berneiser S., Hempel S.,
RA   Feldpausch M., Lamberth S., Van den Daele H., De Keyser A., Buysshaert C.,
RA   Gielen J., Villarroel R., De Clercq R., van Montagu M., Rogers J.,
RA   Cronin A., Quail M.A., Bray-Allen S., Clark L., Doggett J., Hall S.,
RA   Kay M., Lennard N., McLay K., Mayes R., Pettett A., Rajandream M.A.,
RA   Lyne M., Benes V., Rechmann S., Borkova D., Bloecker H., Scharfe M.,
RA   Grimm M., Loehnert T.-H., Dose S., de Haan M., Maarse A.C., Schaefer M.,
RA   Mueller-Auer S., Gabel C., Fuchs M., Fartmann B., Granderath K., Dauner D.,
RA   Herzl A., Neumann S., Argiriou A., Vitale D., Liguori R., Piravandi E.,
RA   Massenet O., Quigley F., Clabauld G., Muendlein A., Felber R., Schnabl S.,
RA   Hiller R., Schmidt W., Lecharny A., Aubourg S., Chefdor F., Cooke R.,
RA   Berger C., Monfort A., Casacuberta E., Gibbons T., Weber N., Vandenbol M.,
RA   Bargues M., Terol J., Torres A., Perez-Perez A., Purnelle B., Bent E.,
RA   Johnson S., Tacon D., Jesse T., Heijnen L., Schwarz S., Scholler P.,
RA   Heber S., Francs P., Bielke C., Frishman D., Haase D., Lemcke K.,
RA   Mewes H.-W., Stocker S., Zaccaria P., Bevan M., Wilson R.K.,
RA   de la Bastide M., Habermann K., Parnell L., Dedhia N., Gnoj L., Schutz K.,
RA   Huang E., Spiegel L., Sekhon M., Murray J., Sheet P., Cordes M.,
RA   Abu-Threideh J., Stoneking T., Kalicki J., Graves T., Harmon G.,
RA   Edwards J., Latreille P., Courtney L., Cloud J., Abbott A., Scott K.,
RA   Johnson D., Minx P., Bentley D., Fulton B., Miller N., Greco T., Kemp K.,
RA   Kramer J., Fulton L., Mardis E., Dante M., Pepin K., Hillier L.W.,
RA   Nelson J., Spieth J., Ryan E., Andrews S., Geisel C., Layman D., Du H.,
RA   Ali J., Berghoff A., Jones K., Drone K., Cotton M., Joshu C., Antonoiu B.,
RA   Zidanic M., Strong C., Sun H., Lamar B., Yordan C., Ma P., Zhong J.,
RA   Preston R., Vil D., Shekher M., Matero A., Shah R., Swaby I.K.,
RA   O'Shaughnessy A., Rodriguez M., Hoffman J., Till S., Granat S., Shohdy N.,
RA   Hasegawa A., Hameed A., Lodhi M., Johnson A., Chen E., Marra M.A.,
RA   Martienssen R., McCombie W.R.;
RT   "Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana.";
RL   Nature 402:769-777(1999).
RN   [3]
RP   GENOME REANNOTATION.
RC   STRAIN=cv. Columbia;
RX   PubMed=27862469; DOI=10.1111/tpj.13415;
RA   Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA   Town C.D.;
RT   "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT   genome.";
RL   Plant J. 89:789-804(2017).
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-333.
RC   STRAIN=cv. Columbia;
RA   Bautista V.R., Kim C.J., Chen H., Quinitio C., Ecker J.R.;
RT   "Arabidopsis ORF clones.";
RL   Submitted (DEC-2006) to the EMBL/GenBank/DDBJ databases.
RN   [5]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 6-333.
RA   Fujita M., Mizukado S., Seki M., Shinozaki K., Mitsuda N., Takiguchi Y.,
RA   Takagi M.;
RT   "ORF cloning and analysis of Arabidopsis transcription factor genes.";
RL   Submitted (MAR-2009) to the EMBL/GenBank/DDBJ databases.
RN   [6]
RP   FUNCTION.
RX   PubMed=16603651; DOI=10.1105/tpc.105.040725;
RA   Alvarez J.P., Pekker I., Goldshmidt A., Blum E., Amsellem Z., Eshed Y.;
RT   "Endogenous and synthetic microRNAs stimulate simultaneous, efficient, and
RT   localized regulation of multiple targets in diverse species.";
RL   Plant Cell 18:1134-1151(2006).
RN   [7]
RP   GENE FAMILY.
RX   PubMed=18986826; DOI=10.1016/j.tplants.2008.09.006;
RA   Swaminathan K., Peterson K., Jack T.;
RT   "The plant B3 superfamily.";
RL   Trends Plant Sci. 13:647-655(2008).
CC   -!- FUNCTION: Regulates lateral organ growth. Functionally redundant with
CC       NGA1, NGA2 and NGA3. {ECO:0000269|PubMed:16603651}.
CC   -!- INTERACTION:
CC       O82595; O80748: B-box domain protein 26; NbExp=3; IntAct=EBI-15193945, EBI-15191535;
CC       O82595; Q9SIV3: GLK1; NbExp=3; IntAct=EBI-15193945, EBI-4442165;
CC       O82595; Q9LDT3: YAB4; NbExp=3; IntAct=EBI-15193945, EBI-1115523;
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC62776.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=ACP18974.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
CC       Sequence=CAB77720.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR   EMBL; FJ873734; ACP18974.1; ALT_INIT; mRNA.
DR   EMBL; AF096370; AAC62776.1; ALT_INIT; Genomic_DNA.
DR   EMBL; AL161492; CAB77720.1; ALT_INIT; Genomic_DNA.
DR   EMBL; CP002687; AEE82033.1; -; Genomic_DNA.
DR   EMBL; BT029520; ABL66776.1; -; mRNA.
DR   EMBL; AB493670; BAH30508.1; -; mRNA.
DR   PIR; T01944; T01944.
DR   RefSeq; NP_192059.4; NM_116380.6.
DR   AlphaFoldDB; O82595; -.
DR   SMR; O82595; -.
DR   BioGRID; 12049; 11.
DR   IntAct; O82595; 9.
DR   STRING; 3702.AT4G01500.1; -.
DR   PaxDb; O82595; -.
DR   PRIDE; O82595; -.
DR   ProteomicsDB; 251147; -.
DR   EnsemblPlants; AT4G01500.1; AT4G01500.1; AT4G01500.
DR   GeneID; 826750; -.
DR   Gramene; AT4G01500.1; AT4G01500.1; AT4G01500.
DR   KEGG; ath:AT4G01500; -.
DR   Araport; AT4G01500; -.
DR   TAIR; locus:2117007; AT4G01500.
DR   eggNOG; ENOG502QSHQ; Eukaryota.
DR   HOGENOM; CLU_038898_3_2_1; -.
DR   InParanoid; O82595; -.
DR   OMA; WNLGRSE; -.
DR   OrthoDB; 661086at2759; -.
DR   PRO; PR:O82595; -.
DR   Proteomes; UP000006548; Chromosome 4.
DR   ExpressionAtlas; O82595; baseline and differential.
DR   Genevisible; O82595; AT.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR   GO; GO:0003700; F:DNA-binding transcription factor activity; ISS:TAIR.
DR   GO; GO:0009908; P:flower development; IMP:TAIR.
DR   GO; GO:0048366; P:leaf development; IMP:TAIR.
DR   GO; GO:1901371; P:regulation of leaf morphogenesis; IGI:TAIR.
DR   CDD; cd10017; B3_DNA; 1.
DR   Gene3D; 2.40.330.10; -; 1.
DR   InterPro; IPR003340; B3_DNA-bd.
DR   InterPro; IPR015300; DNA-bd_pseudobarrel_sf.
DR   InterPro; IPR044800; LEC2-like.
DR   PANTHER; PTHR31140; PTHR31140; 1.
DR   Pfam; PF02362; B3; 1.
DR   SMART; SM01019; B3; 1.
DR   SUPFAM; SSF101936; SSF101936; 1.
DR   PROSITE; PS50863; B3; 1.
PE   1: Evidence at protein level;
KW   DNA-binding; Nucleus; Reference proteome; Transcription;
KW   Transcription regulation.
FT   CHAIN           1..333
FT                   /note="B3 domain-containing transcription factor NGA4"
FT                   /id="PRO_0000375094"
FT   DNA_BIND        36..145
FT                   /note="TF-B3"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00326"
FT   REGION          268..333
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        319..333
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   333 AA;  38512 MW;  196E05E4D2A3C123 CRC64;
     MNISTMNLDQ ELAEIRASSS DHTNYFYSSE RREHMFDKVL TPSDVGKLNR LVIPKQHAEN
     FFPLEDNQNG TVLDFQDKNG KMWRFRYSYW NSSQSYVMTK GWSRFVKEKK LFAGDTVSFY
     RGYIPDDNAQ PERRRKIMFI DWRPRAEINF VHNINNHNFV FGSPTYPTAR FYPVTPEYSM
     PYRSFPPFYQ NQFQEREYLG YGYGRVVNGN GVRYYAGSPL DQHHQWNLGR SEPLVYDSVP
     VFPAGRVPPS APPQPSTTKK LRLFGVDVEE SSSSGDTRGE MGVAGYSSSS PVVIRDDDQS
     FWRSPRGEMA SSSSAMQLSD DEEYKRKGKS LEL