ID   NGB2_ONCMY              Reviewed;         159 AA.
AC   P59743;
DT   20-JUN-2003, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2003, sequence version 1.
DT   03-AUG-2022, entry version 67.
DE   RecName: Full=Neuroglobin-2;
GN   Name=ngb2;
OS   Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Protacanthopterygii; Salmoniformes;
OC   Salmonidae; Salmoninae; Oncorhynchus.
OX   NCBI_TaxID=8022;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Rosner A., Milke C., Hankeln T., Burmester T.;
RT   "Neuroglobin cDNA sequences of from the rainbow trout, Oncorhynchus
RT   mykiss.";
RL   Submitted (FEB-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Involved in oxygen transport in the brain. Hexacoordinate
CC       globin, displaying competitive binding of oxygen or the distal His
CC       residue to the iron atom. Capable of penetrating cell membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Perikaryon {ECO:0000250}. Cytoplasm
CC       {ECO:0000250}. Note=Located in the soma (perikaryon) of most nerve
CC       cells in brain. Has ability to penetrate cell membranes and translocate
CC       into cells (By similarity). {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; AJ547801; CAD68069.1; -; mRNA.
DR   RefSeq; NP_001117861.1; NM_001124389.1.
DR   AlphaFoldDB; P59743; -.
DR   SMR; P59743; -.
DR   Ensembl; ENSOMYT00000140979; ENSOMYP00000136328; ENSOMYG00000053114.
DR   GeneID; 100136083; -.
DR   KEGG; omy:100136083; -.
DR   CTD; 58157; -.
DR   OrthoDB; 1529889at2759; -.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0098809; F:nitrite reductase activity; IEA:Ensembl.
DR   GO; GO:0019825; F:oxygen binding; IEA:Ensembl.
DR   GO; GO:0005344; F:oxygen carrier activity; IEA:UniProtKB-KW.
DR   GO; GO:0001666; P:response to hypoxia; IEA:Ensembl.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   Pfam; PF00042; Globin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Heme; Iron; Metal-binding; Oxygen transport; Transport.
FT   CHAIN           1..159
FT                   /note="Neuroglobin-2"
FT                   /id="PRO_0000053400"
FT   REGION          2..153
FT                   /note="Globin"
FT   BINDING         66
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         98
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   SITE            7
FT                   /note="Essential for protein transduction into cells"
FT                   /evidence="ECO:0000250"
FT   SITE            9
FT                   /note="Essential for protein transduction into cells"
FT                   /evidence="ECO:0000250"
FT   SITE            21
FT                   /note="Essential for protein transduction into cells"
FT                   /evidence="ECO:0000250"
FT   SITE            23
FT                   /note="Essential for protein transduction into cells"
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   159 AA;  17829 MW;  F1F6AD4D01143059 CRC64;
     MEKLTEKDKE LIRGSWESLG KNKVPHGVVM FSRLFELEPA LLNLFHYNTN CSPTQDCLSS
     PEFLDHVTKV MLVIDAAVSH LDDLHTLEDF LLNLGKKHQA VGVNTQSFAV VGESLLYMLQ
     CSLGHGYTGP LRQAWLNMYT IVVAAMSRGW AKNGEHKTD