ID   NGB_BOVIN               Reviewed;         151 AA.
AC   Q6WZ19; Q6KC88;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 106.
DE   RecName: Full=Neuroglobin;
GN   Name=NGB;
OS   Bos taurus (Bovine).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC   Bovinae; Bos.
OX   NCBI_TaxID=9913;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=15804835; DOI=10.1080/15216540500037257;
RA   Burmester T., Haberkamp M., Mitz S., Roesner A., Schmidt M., Ebner B.,
RA   Gerlach F., Fuchs C., Hankeln T.;
RT   "Neuroglobin and cytoglobin: genes, proteins and evolution.";
RL   IUBMB Life 56:703-707(2004).
CC   -!- FUNCTION: Involved in oxygen transport in the brain. Hexacoordinate
CC       globin, displaying competitive binding of oxygen or the distal His
CC       residue to the iron atom. Not capable of penetrating cell membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Homodimer and homotetramer; disulfide-linked.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Perikaryon {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; AJ635234; CAG25616.2; -; mRNA.
DR   RefSeq; NP_001001853.1; NM_001001853.1.
DR   AlphaFoldDB; Q6WZ19; -.
DR   SMR; Q6WZ19; -.
DR   STRING; 9913.ENSBTAP00000021661; -.
DR   PaxDb; Q6WZ19; -.
DR   Ensembl; ENSBTAT00000021661; ENSBTAP00000021661; ENSBTAG00000016285.
DR   GeneID; 414920; -.
DR   KEGG; bta:414920; -.
DR   CTD; 58157; -.
DR   VEuPathDB; HostDB:ENSBTAG00000016285; -.
DR   VGNC; VGNC:32058; NGB.
DR   eggNOG; KOG3378; Eukaryota.
DR   GeneTree; ENSGT00510000048375; -.
DR   HOGENOM; CLU_003827_13_5_1; -.
DR   InParanoid; Q6WZ19; -.
DR   OMA; DEMKEAW; -.
DR   OrthoDB; 1529889at2759; -.
DR   TreeFam; TF333247; -.
DR   Reactome; R-BTA-8981607; Intracellular oxygen transport.
DR   Proteomes; UP000009136; Chromosome 10.
DR   Bgee; ENSBTAG00000016285; Expressed in hypothalamus and 54 other tissues.
DR   ExpressionAtlas; Q6WZ19; baseline.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR   GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR   GO; GO:0015671; P:oxygen transport; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IBA:GO_Central.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   Pfam; PF00042; Globin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Heme; Iron; Metal-binding; Oxygen transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..151
FT                   /note="Neuroglobin"
FT                   /id="PRO_0000053388"
FT   REGION          1..149
FT                   /note="Globin"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         96
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   DISULFID        46..55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   151 AA;  16904 MW;  E11B4A823039D38F CRC64;
     MELPEPELIR QSWREVSRSP LEHGTVLFAR LFDLEPDLLP LFQYNCRQFS SPEDCLSSPE
     FLDHIRKVML VIDAAVTNVE DLSSLEEYLA GLGRKHRAVG VKLSSFSTVG ESLLYMLEKC
     LGPAFTPATR AAWSQLYGAV VQAMSRGWGG E