ID   NGB_MACMU               Reviewed;         151 AA.
AC   Q6WZ20; Q3KN64;
DT   16-AUG-2004, integrated into UniProtKB/Swiss-Prot.
DT   13-JUN-2006, sequence version 2.
DT   03-AUG-2022, entry version 105.
DE   RecName: Full=Neuroglobin;
GN   Name=NGB;
OS   Macaca mulatta (Rhesus macaque).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini;
OC   Cercopithecidae; Cercopithecinae; Macaca.
OX   NCBI_TaxID=9544;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   PubMed=15804835; DOI=10.1080/15216540500037257;
RA   Burmester T., Haberkamp M., Mitz S., Roesner A., Schmidt M., Ebner B.,
RA   Gerlach F., Fuchs C., Hankeln T.;
RT   "Neuroglobin and cytoglobin: genes, proteins and evolution.";
RL   IUBMB Life 56:703-707(2004).
CC   -!- FUNCTION: Involved in oxygen transport in the brain. Hexacoordinate
CC       globin, displaying competitive binding of oxygen or the distal His
CC       residue to the iron atom. Not capable of penetrating cell membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Homodimer and homotetramer; disulfide-linked.
CC       {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Perikaryon {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BN000827; CAJ30482.1; -; mRNA.
DR   RefSeq; NP_001030591.1; NM_001035514.1.
DR   AlphaFoldDB; Q6WZ20; -.
DR   BMRB; Q6WZ20; -.
DR   SMR; Q6WZ20; -.
DR   STRING; 9544.ENSMMUP00000001458; -.
DR   Ensembl; ENSMMUT00000072435; ENSMMUP00000056314; ENSMMUG00000048130.
DR   GeneID; 641331; -.
DR   KEGG; mcc:641331; -.
DR   CTD; 58157; -.
DR   VEuPathDB; HostDB:ENSMMUG00000048130; -.
DR   VGNC; VGNC:84408; NGB.
DR   eggNOG; KOG3378; Eukaryota.
DR   GeneTree; ENSGT00510000048375; -.
DR   HOGENOM; CLU_003827_13_5_1; -.
DR   InParanoid; Q6WZ20; -.
DR   OMA; MQRGWET; -.
DR   OrthoDB; 1529889at2759; -.
DR   TreeFam; TF333247; -.
DR   Proteomes; UP000006718; Chromosome 7.
DR   Bgee; ENSMMUG00000048130; Expressed in dorsolateral prefrontal cortex and 6 other tissues.
DR   ExpressionAtlas; Q6WZ20; baseline.
DR   GO; GO:0043204; C:perikaryon; IEA:UniProtKB-SubCell.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR   GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR   GO; GO:0015671; P:oxygen transport; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IBA:GO_Central.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   Pfam; PF00042; Globin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Heme; Iron; Metal-binding; Oxygen transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..151
FT                   /note="Neuroglobin"
FT                   /id="PRO_0000053391"
FT   REGION          1..149
FT                   /note="Globin"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         96
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   DISULFID        46..55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   151 AA;  16963 MW;  45BF52A7D77B9CE3 CRC64;
     MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS SPEDCLSSPE
     FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG VKLSSFSTVG ESLLYMLEKC
     LGPAFTPATR AAWSQLYGAV VQAMSRGWDS E