ID   NGB_PANTR               Reviewed;         151 AA.
AC   Q3KN66;
DT   07-FEB-2006, integrated into UniProtKB/Swiss-Prot.
DT   08-NOV-2005, sequence version 1.
DT   03-AUG-2022, entry version 93.
DE   RecName: Full=Neuroglobin;
GN   Name=NGB;
OS   Pan troglodytes (Chimpanzee).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pan.
OX   NCBI_TaxID=9598;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=16136131; DOI=10.1038/nature04072;
RG   Chimpanzee sequencing and analysis consortium;
RT   "Initial sequence of the chimpanzee genome and comparison with the human
RT   genome.";
RL   Nature 437:69-87(2005).
RN   [2]
RP   IDENTIFICATION.
RX   PubMed=15804835; DOI=10.1080/15216540500037257;
RA   Burmester T., Haberkamp M., Mitz S., Roesner A., Schmidt M., Ebner B.,
RA   Gerlach F., Fuchs C., Hankeln T.;
RT   "Neuroglobin and cytoglobin: genes, proteins and evolution.";
RL   IUBMB Life 56:703-707(2004).
CC   -!- FUNCTION: Involved in oxygen transport in the brain. Hexacoordinate
CC       globin, displaying competitive binding of oxygen or the distal His
CC       residue to the iron atom. Not capable of penetrating cell membranes (By
CC       similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Monomer. Homodimer and homotetramer; disulfide-linked.
CC       {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the globin family. {ECO:0000255|PROSITE-
CC       ProRule:PRU00238}.
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DR   EMBL; AADA01016196; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; BN000825; CAJ30481.1; -; mRNA.
DR   RefSeq; NP_001030585.1; NM_001035508.1.
DR   AlphaFoldDB; Q3KN66; -.
DR   BMRB; Q3KN66; -.
DR   SMR; Q3KN66; -.
DR   STRING; 9598.ENSPTRP00000011169; -.
DR   PaxDb; Q3KN66; -.
DR   Ensembl; ENSPTRT00000012061; ENSPTRP00000011169; ENSPTRG00000006575.
DR   GeneID; 467518; -.
DR   KEGG; ptr:467518; -.
DR   CTD; 58157; -.
DR   VGNC; VGNC:12565; NGB.
DR   eggNOG; KOG3378; Eukaryota.
DR   GeneTree; ENSGT00510000048375; -.
DR   HOGENOM; CLU_003827_13_5_1; -.
DR   InParanoid; Q3KN66; -.
DR   OMA; MQRGWET; -.
DR   OrthoDB; 1529889at2759; -.
DR   TreeFam; TF333247; -.
DR   Proteomes; UP000002277; Chromosome 14.
DR   Bgee; ENSPTRG00000006575; Expressed in dorsolateral prefrontal cortex and 7 other tissues.
DR   GO; GO:0020037; F:heme binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0019825; F:oxygen binding; IBA:GO_Central.
DR   GO; GO:0005344; F:oxygen carrier activity; IBA:GO_Central.
DR   GO; GO:0015671; P:oxygen transport; IBA:GO_Central.
DR   GO; GO:0001666; P:response to hypoxia; IBA:GO_Central.
DR   Gene3D; 1.10.490.10; -; 1.
DR   InterPro; IPR000971; Globin.
DR   InterPro; IPR009050; Globin-like_sf.
DR   InterPro; IPR012292; Globin/Proto.
DR   Pfam; PF00042; Globin; 1.
DR   SUPFAM; SSF46458; SSF46458; 1.
DR   PROSITE; PS01033; GLOBIN; 1.
PE   2: Evidence at transcript level;
KW   Disulfide bond; Heme; Iron; Metal-binding; Oxygen transport;
KW   Reference proteome; Transport.
FT   CHAIN           1..151
FT                   /note="Neuroglobin"
FT                   /id="PRO_0000053394"
FT   REGION          1..149
FT                   /note="Globin"
FT   BINDING         64
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="distal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   BINDING         96
FT                   /ligand="heme b"
FT                   /ligand_id="ChEBI:CHEBI:60344"
FT                   /ligand_part="Fe"
FT                   /ligand_part_id="ChEBI:CHEBI:18248"
FT                   /note="proximal binding residue"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00238"
FT   DISULFID        46..55
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   151 AA;  16933 MW;  45A292A7D77B9CE3 CRC64;
     MERPEPELIR QSWRAVSRSP LEHGTVLFAR LFALEPDLLP LFQYNCRQFS SPEDCLSSPE
     FLDHIRKVML VIDAAVTNVE DLSSLEEYLA SLGRKHRAVG VKLSSFSTVG ESLLYMLEKC
     LGPAFTPATR AAWSQLYGAV VQAMSRGWDG E