ID   NGCG_STRCO              Reviewed;         302 AA.
AC   O50501;
DT   18-SEP-2019, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1998, sequence version 1.
DT   25-MAY-2022, entry version 120.
DE   RecName: Full=Diacetylchitobiose uptake system permease protein NgcG {ECO:0000305};
GN   Name=ngcG {ECO:0000303|PubMed:30089751};
GN   OrderedLocusNames=SCO6007 {ECO:0000312|EMBL:CAA15784.1};
OS   Streptomyces coelicolor (strain ATCC BAA-471 / A3(2) / M145).
OC   Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
OC   Streptomyces; Streptomyces albidoflavus group.
OX   NCBI_TaxID=100226;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=12000953; DOI=10.1038/417141a;
RA   Bentley S.D., Chater K.F., Cerdeno-Tarraga A.-M., Challis G.L.,
RA   Thomson N.R., James K.D., Harris D.E., Quail M.A., Kieser H., Harper D.,
RA   Bateman A., Brown S., Chandra G., Chen C.W., Collins M., Cronin A.,
RA   Fraser A., Goble A., Hidalgo J., Hornsby T., Howarth S., Huang C.-H.,
RA   Kieser T., Larke L., Murphy L.D., Oliver K., O'Neil S., Rabbinowitsch E.,
RA   Rajandream M.A., Rutherford K.M., Rutter S., Seeger K., Saunders D.,
RA   Sharp S., Squares R., Squares S., Taylor K., Warren T., Wietzorrek A.,
RA   Woodward J.R., Barrell B.G., Parkhill J., Hopwood D.A.;
RT   "Complete genome sequence of the model actinomycete Streptomyces coelicolor
RT   A3(2).";
RL   Nature 417:141-147(2002).
RN   [2]
RP   FUNCTION, SUBUNIT, AND INDUCTION.
RC   STRAIN=ATCC BAA-471 / A3(2) / M145;
RX   PubMed=30089751; DOI=10.1264/jsme2.me17172;
RA   Iinuma C., Saito A., Ohnuma T., Tenconi E., Rosu A., Colson S.,
RA   Mizutani Y., Liu F., Swiatek-Polatynska M., van Wezel G.P., Rigali S.,
RA   Fujii T., Miyashita K.;
RT   "NgcESco acts as a lower-affinity binding protein of an ABC transporter for
RT   the uptake of N,N'-diacetylchitobiose in Streptomyces coelicolor A3(2).";
RL   Microbes Environ. 33:272-281(2018).
CC   -!- FUNCTION: Part of the ABC transporter complex NgcEFG-MsiK involved in
CC       N,N'-diacetylchitobiose ((GlcNAc)2) uptake. Responsible for the
CC       translocation of the substrate across the membrane.
CC       {ECO:0000305|PubMed:30089751}.
CC   -!- SUBUNIT: The complex is composed of two ATP-binding proteins (MsiK),
CC       two transmembrane proteins (NgcF and NgcG) and a solute-binding protein
CC       (NgcE). {ECO:0000305|PubMed:30089751}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC       protein {ECO:0000255}.
CC   -!- INDUCTION: Constitutively expressed. Slightly induced by GlcNAc,
CC       (GlcNAc)2 and chitin. Repressed by DasR. {ECO:0000269|PubMed:30089751}.
CC   -!- SIMILARITY: Belongs to the binding-protein-dependent transport system
CC       permease family. {ECO:0000305}.
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DR   EMBL; AL939126; CAA15784.1; -; Genomic_DNA.
DR   PIR; T35672; T35672.
DR   RefSeq; NP_630121.1; NC_003888.3.
DR   RefSeq; WP_011030593.1; NZ_VNID01000007.1.
DR   AlphaFoldDB; O50501; -.
DR   SMR; O50501; -.
DR   STRING; 100226.SCO6007; -.
DR   GeneID; 1101449; -.
DR   KEGG; sco:SCO6007; -.
DR   PATRIC; fig|100226.15.peg.6105; -.
DR   eggNOG; COG0395; Bacteria.
DR   HOGENOM; CLU_016047_1_2_11; -.
DR   InParanoid; O50501; -.
DR   OMA; IAVMILW; -.
DR   PhylomeDB; O50501; -.
DR   Proteomes; UP000001973; Chromosome.
DR   GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0055085; P:transmembrane transport; IEA:InterPro.
DR   CDD; cd06261; TM_PBP2; 1.
DR   Gene3D; 1.10.3720.10; -; 1.
DR   InterPro; IPR000515; MetI-like.
DR   InterPro; IPR035906; MetI-like_sf.
DR   Pfam; PF00528; BPD_transp_1; 1.
DR   SUPFAM; SSF161098; SSF161098; 1.
DR   PROSITE; PS50928; ABC_TM1; 1.
PE   1: Evidence at protein level;
KW   Cell membrane; Membrane; Reference proteome; Sugar transport;
KW   Transmembrane; Transmembrane helix; Transport.
FT   CHAIN           1..302
FT                   /note="Diacetylchitobiose uptake system permease protein
FT                   NgcG"
FT                   /id="PRO_0000447877"
FT   TRANSMEM        40..60
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        99..119
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        131..151
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        166..186
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        221..241
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        268..288
FT                   /note="Helical"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          95..288
FT                   /note="ABC transmembrane type-1"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00441"
SQ   SEQUENCE   302 AA;  33764 MW;  06A5B64191480034 CRC64;
     MSVIAADRKP ASDRKPVSDR KLARAAASSD RRFAAISHAL LILWSVIVIV PMLWVLMSSF
     KSTGEILSSP FSLPDHWRFE NYANAWTDAN IGKYFLNSVI VVVSALILVM LLGAMCAYVL
     ARFEFPGRRL IYYVMLAGLT FPVFLAIVPL FFQLQNFGLL NTRPGLILTY VAFALPFTMF
     FLYSFFRSLP HDVYEAALID GAGDWRAFFQ VMLPMARPGM AAVAIFNFLG LWNQFLLPVA
     LNTDQDKWVL TQGMAAYASS QVYDIDYGAL FAAIVVTVVP VLLVYCVFQR RIAGSVSQGT
     FR