ID   NGDNA_XENLA             Reviewed;         317 AA.
AC   Q4KLC4;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   02-AUG-2005, sequence version 1.
DT   03-AUG-2022, entry version 42.
DE   RecName: Full=Neuroguidin-A;
DE   AltName: Full=EIF4E-binding protein A;
GN   Name=ngdn-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16705177; DOI=10.1128/mcb.02470-05;
RA   Jung M.-Y., Lorenz L., Richter J.D.;
RT   "Translational control by neuroguidin, a eukaryotic initiation factor 4E
RT   and CPEB binding protein.";
RL   Mol. Cell. Biol. 26:4277-4287(2006).
CC   -!- FUNCTION: May inhibit mRNA translation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from the early tailbud stage (at protein
CC       level). Expressed in animal pole blastomeres of the four-cell embryo
CC       and in the neural crest and neural folds of the neurula stage embryo.
CC       {ECO:0000269|PubMed:16705177}.
CC   -!- SIMILARITY: Belongs to the SAS10 family. {ECO:0000305}.
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DR   EMBL; BC099295; AAH99295.1; -; mRNA.
DR   RefSeq; NP_001088857.1; NM_001095388.1.
DR   AlphaFoldDB; Q4KLC4; -.
DR   SMR; Q4KLC4; -.
DR   MaxQB; Q4KLC4; -.
DR   DNASU; 496169; -.
DR   GeneID; 496169; -.
DR   KEGG; xla:496169; -.
DR   CTD; 496169; -.
DR   Xenbase; XB-GENE-946315; ngdn.L.
DR   OrthoDB; 1511802at2759; -.
DR   Proteomes; UP000186698; Chromosome 1L.
DR   Bgee; 496169; Expressed in neurula embryo and 19 other tissues.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR007146; Sas10/Utp3/C1D.
DR   PANTHER; PTHR13237; PTHR13237; 1.
DR   Pfam; PF04000; Sas10_Utp3; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Repressor; Translation regulation.
FT   CHAIN           1..317
FT                   /note="Neuroguidin-A"
FT                   /id="PRO_0000269248"
FT   REGION          125..170
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..317
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        142..158
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..317
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   317 AA;  36108 MW;  15354A82768F4710 CRC64;
     MAAAGDVILE DVPGSVNLFN TLQDQITKVT AHVQDLTQKV RSGIYNTDKG LSFLELKDQL
     LLFYLQDLTH LMLEKTNGKS IKGNPGILRL VELRTVLEKM RPIDQKLKYQ IDKLVKAAVT
     GSLGENDPLR FKPNPQNLMS KLSEPDERES DSGEEGAEGG VAKKPQSKVK RYIPPRLAPV
     HYDDTEAERE HRIVERAKKL ALSSSTIREL KEQYSDAPEE IREGRAYHMM RHDKEEQHRI
     NHEESMMVRL NMTRKEKARK KRVLSMTSQL NSLTHFSDIS ALTGGEGRAE DMVPSMKKSK
     KGPKKSKKKK GFSRRRH