ID   NGDNB_XENLA             Reviewed;         316 AA.
AC   Q5M985;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-2005, sequence version 1.
DT   25-MAY-2022, entry version 39.
DE   RecName: Full=Neuroguidin-B;
DE   AltName: Full=EIF4E-binding protein B;
DE   Flags: Fragment;
GN   Name=ngdn-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Testis;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (DEC-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   DEVELOPMENTAL STAGE.
RX   PubMed=16705177; DOI=10.1128/mcb.02470-05;
RA   Jung M.-Y., Lorenz L., Richter J.D.;
RT   "Translational control by neuroguidin, a eukaryotic initiation factor 4E
RT   and CPEB binding protein.";
RL   Mol. Cell. Biol. 26:4277-4287(2006).
CC   -!- FUNCTION: May inhibit mRNA translation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- DEVELOPMENTAL STAGE: Expressed from the early tailbud stage (at protein
CC       level). Expressed in animal pole blastomeres of the four-cell embryo
CC       and in the neural crest and neural folds of the neurula stage embryo.
CC       {ECO:0000269|PubMed:16705177}.
CC   -!- SIMILARITY: Belongs to the SAS10 family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; BC087522; AAH87522.1; -; mRNA.
DR   AlphaFoldDB; Q5M985; -.
DR   SMR; Q5M985; -.
DR   Proteomes; UP000186698; Genome assembly.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR007146; Sas10/Utp3/C1D.
DR   PANTHER; PTHR13237; PTHR13237; 1.
DR   Pfam; PF04000; Sas10_Utp3; 1.
PE   1: Evidence at protein level;
KW   Cytoplasm; Nucleus; Reference proteome; Repressor; Translation regulation.
FT   CHAIN           <1..316
FT                   /note="Neuroguidin-B"
FT                   /id="PRO_0000269249"
FT   REGION          124..169
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          292..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        141..157
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..316
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   NON_TER         1
SQ   SEQUENCE   316 AA;  36067 MW;  2574B57C95AD6A98 CRC64;
     AAAGDVILED VPGSVNLFNT LQDQITKVTA HVQDLTQKVR SSIYNTDKGL SFLELKDQLL
     LFYLQDLTHL MLEKTNGKSI KGNPGILRLV ELRTVLEKMR PIDQKLKYQI DKLVKAAVTG
     SLGENDPLRF KPNPQNLMSK LSEPDERESD SGEEGAEGGV AKKPQSKVKR YIPPRLAPVH
     YDDTEAEREH RIVERAKKLA LSSSTIRELK EQYSDAPEEI REGRAYHMMR HDKEEQHRIN
     HEESMMVRLN MTRKEKARKK RVLSMTSQLN SLTHFSDISA LTGGEGRAED MVPFMKKSKK
     GPKKSKKKKG FSRRRH