ID   NGDN_DANRE              Reviewed;         315 AA.
AC   Q6PFJ1;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 81.
DE   RecName: Full=Neuroguidin;
DE   AltName: Full=EIF4E-binding protein;
GN   Name=ngdn; ORFNames=zgc:66416;
OS   Danio rerio (Zebrafish) (Brachydanio rerio).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC   Danionidae; Danioninae; Danio.
OX   NCBI_TaxID=7955;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   STRAIN=SJD;
RG   NIH - Zebrafish Gene Collection (ZGC) project;
RL   Submitted (SEP-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May inhibit mRNA translation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SAS10 family. {ECO:0000305}.
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DR   EMBL; BC057531; AAH57531.1; -; mRNA.
DR   RefSeq; NP_938187.2; NM_198373.2.
DR   AlphaFoldDB; Q6PFJ1; -.
DR   SMR; Q6PFJ1; -.
DR   STRING; 7955.ENSDARP00000066720; -.
DR   PaxDb; Q6PFJ1; -.
DR   GeneID; 386642; -.
DR   KEGG; dre:386642; -.
DR   CTD; 25983; -.
DR   ZFIN; ZDB-GENE-031030-13; ngdn.
DR   eggNOG; KOG3117; Eukaryota.
DR   InParanoid; Q6PFJ1; -.
DR   OrthoDB; 1511802at2759; -.
DR   PhylomeDB; Q6PFJ1; -.
DR   PRO; PR:Q6PFJ1; -.
DR   Proteomes; UP000000437; Genome assembly.
DR   Proteomes; UP000814640; Unplaced.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR007146; Sas10/Utp3/C1D.
DR   PANTHER; PTHR13237; PTHR13237; 1.
DR   Pfam; PF04000; Sas10_Utp3; 1.
PE   2: Evidence at transcript level;
KW   Coiled coil; Cytoplasm; Nucleus; Reference proteome; Repressor;
KW   Translation regulation.
FT   CHAIN           1..315
FT                   /note="Neuroguidin"
FT                   /id="PRO_0000269247"
FT   REGION          127..201
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          289..315
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          181..206
FT                   /evidence="ECO:0000255"
FT   COMPBIAS        127..145
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        146..169
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        183..201
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        298..315
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   315 AA;  36201 MW;  D747AE18DBEC76F6 CRC64;
     MAATAVGNDV IDRDLPTAVR LLNSLTEQIV SVTSHVRELI KKVREKAYQT SKGLSFLDLR
     YHLLLFYLQD ITHLISLKTE GESLKDNSAI HRLVTIRTVL EKMRPLDQKL KYQIDKLVRT
     AVTGSLSEND PLHFRPNPQS LVSKLSESED SDDDGVGGKT KEQKEPSGGR RYVPPRIAPM
     HYDGDLTEAD RQKERVEKQK RAALRSSVIQ ELRQQYSDAP EEIRDRRDFQ TDRQGREELN
     RKNYEESMMV RLSTTRDQKL RKRGMMGMTS QLSNITRFSD ITALTGGEVQ DIGNPKPKKK
     KIIKKGKKKV FRKRK