ID   NGDN_XENTR              Reviewed;         316 AA.
AC   Q28IV8; Q6P1T3;
DT   12-DEC-2006, integrated into UniProtKB/Swiss-Prot.
DT   04-APR-2006, sequence version 1.
DT   03-AUG-2022, entry version 60.
DE   RecName: Full=Neuroguidin;
DE   AltName: Full=EIF4E-binding protein;
GN   Name=ngdn; ORFNames=TNeu114c02.1;
OS   Xenopus tropicalis (Western clawed frog) (Silurana tropicalis).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Silurana.
OX   NCBI_TaxID=8364;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Neurula;
RG   Sanger Xenopus tropicalis EST/cDNA project;
RL   Submitted (JUN-2006) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: May inhibit mRNA translation. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the SAS10 family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAH64878.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; CR760199; CAJ83037.1; -; mRNA.
DR   EMBL; BC064878; AAH64878.1; ALT_INIT; mRNA.
DR   RefSeq; NP_001032334.1; NM_001037257.1.
DR   AlphaFoldDB; Q28IV8; -.
DR   SMR; Q28IV8; -.
DR   STRING; 8364.ENSXETP00000058341; -.
DR   PaxDb; Q28IV8; -.
DR   Ensembl; ENSXETT00000031863; ENSXETP00000031863; ENSXETG00000014562.
DR   GeneID; 395016; -.
DR   KEGG; xtr:395016; -.
DR   CTD; 25983; -.
DR   Xenbase; XB-GENE-946309; ngdn.
DR   eggNOG; KOG3117; Eukaryota.
DR   HOGENOM; CLU_031901_0_0_1; -.
DR   InParanoid; Q28IV8; -.
DR   OrthoDB; 1511802at2759; -.
DR   Proteomes; UP000008143; Chromosome 1.
DR   Proteomes; UP000790000; Unplaced.
DR   Bgee; ENSXETG00000014562; Expressed in egg cell and 13 other tissues.
DR   ExpressionAtlas; Q28IV8; baseline.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005730; C:nucleolus; IBA:GO_Central.
DR   GO; GO:0032040; C:small-subunit processome; IBA:GO_Central.
DR   GO; GO:0000462; P:maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); IBA:GO_Central.
DR   GO; GO:0006417; P:regulation of translation; IEA:UniProtKB-KW.
DR   InterPro; IPR007146; Sas10/Utp3/C1D.
DR   PANTHER; PTHR13237; PTHR13237; 1.
DR   Pfam; PF04000; Sas10_Utp3; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Nucleus; Reference proteome; Repressor; Translation regulation.
FT   CHAIN           1..316
FT                   /note="Neuroguidin"
FT                   /id="PRO_0000269250"
FT   REGION          143..172
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          280..316
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        299..316
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   316 AA;  36015 MW;  0DD1CC4FE439F8C0 CRC64;
     MAAPGEIILE DVPASVNLFR TLQDQVTKVT AHVQALTQKV RSGIYNTDKG LSFLELKDQL
     LLFYLQDLTH LMLEKTNGKS IKGNPGILRL VELRTVLEKM RPIDQKLKYQ IDKLVRASVT
     GSLGENDPLR FKPNPQNLIS KLSEADEGES DSGEDCAESG NAKKPQSKVK KYIPPRLAPV
     HYDDTEAERE HRIIERAKKL ALSSSTIREL KEQYSDAPEE IREGRAYHMM RHDKEEQHRI
     NHEESMMVRL NMTRKEKARK KRVLAMTSQL NSLTHFSDIS ALTGGEGRTD DLVPSVKKSR
     KGPKKSKKRK GFRKRH