NGFV_AGKCO
ID NGFV_AGKCO Reviewed; 190 AA.
AC B8QCG6;
DT 19-FEB-2014, integrated into UniProtKB/Swiss-Prot.
DT 03-MAR-2009, sequence version 1.
DT 25-MAY-2022, entry version 35.
DE RecName: Full=Venom nerve growth factor;
DE Short=v-NGF;
DE Short=vNGF;
DE Flags: Precursor; Fragment;
OS Agkistrodon contortrix contortrix (Southern copperhead).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Lepidosauria; Squamata; Bifurcata; Unidentata; Episquamata; Toxicofera;
OC Serpentes; Colubroidea; Viperidae; Crotalinae; Agkistrodon.
OX NCBI_TaxID=8713;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=18570036; DOI=10.1080/10635150802166053;
RA Wiens J.J., Kuczynski C.A., Smith S.A., Mulcahy D.G., Sites J.W. Jr.,
RA Townsend T.M., Reeder T.W.;
RT "Branch lengths, support, and congruence: testing the phylogenomic approach
RT with 20 nuclear loci in snakes.";
RL Syst. Biol. 57:420-431(2008).
RN [2]
RP CHARACTERIZATION, AND GLYCOSYLATION.
RC TISSUE=Venom;
RX PubMed=21801740; DOI=10.1016/j.toxicon.2011.07.005;
RA Trummal K., Tonismagi K., Paalme V., Jarvekulg L., Siigur J., Siigur E.;
RT "Molecular diversity of snake venom nerve growth factors.";
RL Toxicon 58:363-368(2011).
CC -!- FUNCTION: Nerve growth factor is important for the development and
CC maintenance of the sympathetic and sensory nervous systems. It
CC stimulates division and differentiation of sympathetic and embryonic
CC sensory neurons as well as basal forebrain cholinergic neurons in the
CC brain. Its relevance in the snake venom is not clear. However, it has
CC been shown to inhibit metalloproteinase-dependent proteolysis of
CC platelet glycoprotein Ib alpha, suggesting a metalloproteinase
CC inhibition to prevent metalloprotease autodigestion and/or protection
CC against prey proteases (By similarity). Binds a lipid between the two
CC protein chains in the homodimer. The lipid-bound form promotes
CC histamine relase from mouse mast cells, contrary to the lipid-free form
CC (By similarity). {ECO:0000250|UniProtKB:P61898,
CC ECO:0000250|UniProtKB:P61899}.
CC -!- SUBUNIT: Homodimer; non-covalently linked.
CC {ECO:0000250|UniProtKB:P61898}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:21801740}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:21801740}.
CC -!- PTM: Glycosylated. {ECO:0000269|PubMed:21801740}.
CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR EMBL; EU437986; ACC85799.1; -; Genomic_DNA.
DR AlphaFoldDB; B8QCG6; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008289; F:lipid binding; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR020425; Nerve_growth_factor_bsu.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR InterPro; IPR020433; Venom_nerve_growth_factor.
DR PANTHER; PTHR11589; PTHR11589; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR00268; NGF.
DR PRINTS; PR01913; NGFBETA.
DR PRINTS; PR01917; VENOMNGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 1: Evidence at protein level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Lipid-binding; Metalloenzyme inhibitor;
KW Metalloprotease inhibitor; Protease inhibitor; Secreted; Signal; Toxin.
FT SIGNAL <1..7
FT /evidence="ECO:0000255"
FT PROPEP 8..111
FT /evidence="ECO:0000250"
FT /id="PRO_0000425460"
FT CHAIN 112..>190
FT /note="Venom nerve growth factor"
FT /id="PRO_0000425461"
FT CARBOHYD 134
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 125..190
FT /evidence="ECO:0000250|UniProtKB:P61898"
FT NON_TER 1
FT NON_TER 190
SQ SEQUENCE 190 AA; 21385 MW; F97D6D155DD2E095 CRC64;
FLIGIWAAPK SEDNVPLGSP ATSDLSDTSC AKTHEALKTS RNIDQHYPAP KKAEDQEFGS
AANIIVDPKL FQKRRFQSPR VLFSTQPPPL SRDEQNVDNA NSLNRNIRAK REDHPVHNRG
EYSVCDSVNV WVANKTTATD IRGNVVTVMV DVNINNNVYK QYFFETKCRN PNPVPTGCRG
IDARHWNSYC
