ID   NGF_CAVPO               Reviewed;         241 AA.
AC   P19093;
DT   01-NOV-1990, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1990, sequence version 1.
DT   25-MAY-2022, entry version 98.
DE   RecName: Full=Beta-nerve growth factor;
DE            Short=Beta-NGF;
DE   Flags: Precursor;
GN   Name=NGF; Synonyms=NGFB;
OS   Cavia porcellus (Guinea pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Hystricomorpha; Caviidae;
OC   Cavia.
OX   NCBI_TaxID=10141;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Prostate;
RX   PubMed=2926397; DOI=10.1111/j.1471-4159.1989.tb01867.x;
RA   Schwarz M.A., Fisher D., Bradshaw R.A., Isackson P.J.;
RT   "Isolation and sequence of a cDNA clone of beta-nerve growth factor from
RT   the guinea pig prostate gland.";
RL   J. Neurochem. 52:1203-1209(1989).
CC   -!- FUNCTION: Nerve growth factor is important for the development and
CC       maintenance of the sympathetic and sensory nervous systems.
CC       Extracellular ligand for the NTRK1 and NGFR receptors, activates
CC       cellular signaling cascades through those receptor tyrosine kinase to
CC       regulate neuronal proliferation, differentiation and survival. Inhibits
CC       metalloproteinase dependent proteolysis of platelet glycoprotein VI.
CC       {ECO:0000250|UniProtKB:P01138}.
CC   -!- SUBUNIT: Homodimer. Interacts with ADAM10 in a divalent cation-
CC       dependent manner. {ECO:0000250|UniProtKB:P01138}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   PIR; JL0097; JL0097.
DR   AlphaFoldDB; P19093; -.
DR   SMR; P19093; -.
DR   STRING; 10141.ENSCPOP00000017720; -.
DR   eggNOG; ENOG502RYPU; Eukaryota.
DR   InParanoid; P19093; -.
DR   Proteomes; UP000005447; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; ISS:UniProtKB.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR020425; Nerve_growth_factor_bsu.
DR   InterPro; IPR020437; Nerve_growth_factor_bsu_mml.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01925; MAMLNGFBETA.
DR   PRINTS; PR00268; NGF.
DR   PRINTS; PR01913; NGFBETA.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Metalloenzyme inhibitor; Metalloprotease inhibitor;
KW   Protease inhibitor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..121
FT                   /id="PRO_0000019597"
FT   CHAIN           122..241
FT                   /note="Beta-nerve growth factor"
FT                   /id="PRO_0000019598"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        136..201
FT                   /evidence="ECO:0000250|UniProtKB:P01138"
FT   DISULFID        179..229
FT                   /evidence="ECO:0000250|UniProtKB:P01138"
FT   DISULFID        189..231
FT                   /evidence="ECO:0000250|UniProtKB:P01138"
SQ   SEQUENCE   241 AA;  26822 MW;  2F4E26B197804BF4 CRC64;
     MSMLFYTLIT VFLIGIQAEP YSDSNVLSGD TIPQAHWTKL QHSLDTALRR AHSAPAAPIA
     ARVAGQTLNI TVDPRLFKKR RLHSPRVLFS TQPPPLSTDA QDLDFEVDGA ASVNRTHRSK
     RSSTHPVFHM GEFSVCDSVS VWVADKTTAT DIKGKEVTVL AEVNVNNNVF KQYFFETKCR
     DPSPVDSGCR GIDSKHWNSY CTTTHTFVKA LTTANKQAAW RFIRIDTACV CVLNRKAARR
     G