NGF_DANRE
ID NGF_DANRE Reviewed; 194 AA.
AC Q6YBR5; Q504K7;
DT 01-FEB-2005, integrated into UniProtKB/Swiss-Prot.
DT 05-JUL-2004, sequence version 1.
DT 03-AUG-2022, entry version 109.
DE RecName: Full=Nerve growth factor;
DE Short=NGF;
DE Short=zNGF;
DE Flags: Precursor;
GN Name=ngf; Synonyms=ngfb;
OS Danio rerio (Zebrafish) (Brachydanio rerio).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes;
OC Danionidae; Danioninae; Danio.
OX NCBI_TaxID=7955;
RN [1]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA / MRNA].
RX PubMed=14572460; DOI=10.1016/s1044-7431(03)00195-7;
RA Dethleffsen K., Heinrich G., Lauth M., Knapik E.W., Meyer M.;
RT "Insert-containing neurotrophins in teleost fish and their relationship to
RT nerve growth factor.";
RL Mol. Cell. Neurosci. 24:380-394(2003).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Olfactory epithelium;
RG NIH - Zebrafish Gene Collection (ZGC) project;
RL Submitted (MAY-2005) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Nerve growth factor is important for the development and
CC maintenance of the sympathetic and sensory nervous systems. It
CC stimulates division and differentiation of sympathetic and embryonic
CC sensory neurons (By similarity). {ECO:0000250}.
CC -!- SUBUNIT: Homodimer. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR EMBL; AY162414; AAP15472.1; -; Genomic_DNA.
DR EMBL; AY162415; AAO31810.1; -; mRNA.
DR EMBL; AY162416; AAO31811.1; -; mRNA.
DR EMBL; AY162417; AAO31812.1; -; mRNA.
DR EMBL; AY162418; AAO31813.1; -; mRNA.
DR EMBL; AY162419; AAO31814.1; -; mRNA.
DR EMBL; AY162420; AAO31815.1; -; mRNA.
DR EMBL; BC094968; AAH94968.1; -; mRNA.
DR RefSeq; NP_954680.1; NM_199210.1.
DR AlphaFoldDB; Q6YBR5; -.
DR SMR; Q6YBR5; -.
DR STRING; 7955.ENSDARP00000065032; -.
DR PaxDb; Q6YBR5; -.
DR Ensembl; ENSDART00000065033; ENSDARP00000065032; ENSDARG00000014050.
DR Ensembl; ENSDART00000103376; ENSDARP00000094153; ENSDARG00000014050.
DR Ensembl; ENSDART00000132131; ENSDARP00000115321; ENSDARG00000014050.
DR Ensembl; ENSDART00000132347; ENSDARP00000121658; ENSDARG00000014050.
DR Ensembl; ENSDART00000132867; ENSDARP00000121753; ENSDARG00000014050.
DR Ensembl; ENSDART00000143252; ENSDARP00000122624; ENSDARG00000014050.
DR Ensembl; ENSDART00000182255; ENSDARP00000151408; ENSDARG00000014050.
DR GeneID; 58133; -.
DR KEGG; dre:58133; -.
DR CTD; 58133; -.
DR ZFIN; ZDB-GENE-000629-2; ngfb.
DR eggNOG; ENOG502RYPU; Eukaryota.
DR GeneTree; ENSGT00390000007725; -.
DR HOGENOM; CLU_059942_2_0_1; -.
DR InParanoid; Q6YBR5; -.
DR OMA; PLNRTHR; -.
DR OrthoDB; 1156054at2759; -.
DR PhylomeDB; Q6YBR5; -.
DR TreeFam; TF106463; -.
DR Reactome; R-DRE-167060; NGF processing.
DR Reactome; R-DRE-170968; Frs2-mediated activation.
DR Reactome; R-DRE-170984; ARMS-mediated activation.
DR Reactome; R-DRE-177504; Retrograde neurotrophin signalling.
DR Reactome; R-DRE-187042; TRKA activation by NGF.
DR Reactome; R-DRE-198203; PI3K/AKT activation.
DR Reactome; R-DRE-205017; NFG and proNGF binds to p75NTR.
DR Reactome; R-DRE-205043; NRIF signals cell death from the nucleus.
DR Reactome; R-DRE-209543; p75NTR recruits signalling complexes.
DR Reactome; R-DRE-209560; NF-kB is activated and signals survival.
DR Reactome; R-DRE-209563; Axonal growth stimulation.
DR PRO; PR:Q6YBR5; -.
DR Proteomes; UP000000437; Genome assembly.
DR Proteomes; UP000814640; Chromosome 6.
DR Bgee; ENSDARG00000014050; Expressed in alar plate midbrain and 35 other tissues.
DR ExpressionAtlas; Q6YBR5; baseline.
DR GO; GO:0030424; C:axon; IBA:GO_Central.
DR GO; GO:0030425; C:dendrite; IBA:GO_Central.
DR GO; GO:0005615; C:extracellular space; IBA:GO_Central.
DR GO; GO:0008021; C:synaptic vesicle; IBA:GO_Central.
DR GO; GO:0008083; F:growth factor activity; IBA:GO_Central.
DR GO; GO:0005163; F:nerve growth factor receptor binding; IBA:GO_Central.
DR GO; GO:0007613; P:memory; IBA:GO_Central.
DR GO; GO:0050804; P:modulation of chemical synaptic transmission; IBA:GO_Central.
DR GO; GO:0043524; P:negative regulation of neuron apoptotic process; IBA:GO_Central.
DR GO; GO:0021675; P:nerve development; IBA:GO_Central.
DR GO; GO:0038180; P:nerve growth factor signaling pathway; IBA:GO_Central.
DR GO; GO:0048812; P:neuron projection morphogenesis; IBA:GO_Central.
DR GO; GO:0007422; P:peripheral nervous system development; IBA:GO_Central.
DR GO; GO:0048672; P:positive regulation of collateral sprouting; IBA:GO_Central.
DR GO; GO:0033138; P:positive regulation of peptidyl-serine phosphorylation; IBA:GO_Central.
DR GO; GO:0045664; P:regulation of neuron differentiation; IBA:GO_Central.
DR GO; GO:0007169; P:transmembrane receptor protein tyrosine kinase signaling pathway; IBA:GO_Central.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589; PTHR11589; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR00268; NGF.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Reference proteome; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..76
FT /evidence="ECO:0000255"
FT /id="PRO_0000019617"
FT CHAIN 77..194
FT /note="Nerve growth factor"
FT /id="PRO_0000019618"
FT REGION 54..84
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 54..75
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT CARBOHYD 99
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 120
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 90..155
FT /evidence="ECO:0000250"
FT DISULFID 133..183
FT /evidence="ECO:0000250"
FT DISULFID 143..185
FT /evidence="ECO:0000250"
SQ SEQUENCE 194 AA; 21903 MW; 89441401648C50DA CRC64;
MRWSMLVLLL LSCSQTFAQR PGDICPQNPH HGQDVTANTV PTVDPKLFNK RRYRSPRVLF
SEHPPDSEPS RSRTKRKAGP PQHRGVYSVC ESISHWEGNK TKATDITGNE VTVLPDVIIN
NSKKKQYFFE TTCSSGRTGG SGCLGIDARH WNSYCTNSHT FVRALTSFKN LVAWRLIRIN
VACVCVLSRK SWRA
