NGF_MASNA
ID NGF_MASNA Reviewed; 241 AA.
AC P20675;
DT 01-FEB-1991, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1991, sequence version 1.
DT 25-MAY-2022, entry version 91.
DE RecName: Full=Beta-nerve growth factor;
DE Short=Beta-NGF;
DE Flags: Precursor;
GN Name=NGF; Synonyms=NGFB;
OS Mastomys natalensis (African soft-furred rat) (Praomys natalensis).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mastomys.
OX NCBI_TaxID=10112;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RX PubMed=3234767; DOI=10.1016/0378-1119(88)90436-2;
RA Fahnestock M., Bell R.A.;
RT "Molecular cloning of a cDNA encoding the nerve growth factor precursor
RT from Mastomys natalensis.";
RL Gene 69:257-264(1988).
CC -!- FUNCTION: Nerve growth factor is important for the development and
CC maintenance of the sympathetic and sensory nervous systems.
CC Extracellular ligand for the NTRK1 and NGFR receptors, activates
CC cellular signaling cascades through those receptor tyrosine kinase to
CC regulate neuronal proliferation, differentiation and survival. Inhibits
CC metalloproteinase dependent proteolysis of platelet glycoprotein VI.
CC {ECO:0000250|UniProtKB:P01138}.
CC -!- SUBUNIT: Homodimer. Interacts with ADAM10 in a divalent cation-
CC dependent manner. {ECO:0000250|UniProtKB:P01138}.
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAA40599.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; M22748; AAA40599.1; ALT_INIT; mRNA.
DR PIR; JT0343; NGRTBA.
DR AlphaFoldDB; P20675; -.
DR SMR; P20675; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0008191; F:metalloendopeptidase inhibitor activity; ISS:UniProtKB.
DR Gene3D; 2.10.90.10; -; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR020408; Nerve_growth_factor-like.
DR InterPro; IPR002072; Nerve_growth_factor-rel.
DR InterPro; IPR020425; Nerve_growth_factor_bsu.
DR InterPro; IPR020437; Nerve_growth_factor_bsu_mml.
DR InterPro; IPR019846; Nerve_growth_factor_CS.
DR PANTHER; PTHR11589; PTHR11589; 1.
DR Pfam; PF00243; NGF; 1.
DR PIRSF; PIRSF001789; NGF; 1.
DR PRINTS; PR01925; MAMLNGFBETA.
DR PRINTS; PR00268; NGF.
DR PRINTS; PR01913; NGFBETA.
DR SMART; SM00140; NGF; 1.
DR SUPFAM; SSF57501; SSF57501; 1.
DR PROSITE; PS00248; NGF_1; 1.
DR PROSITE; PS50270; NGF_2; 1.
PE 2: Evidence at transcript level;
KW Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW Growth factor; Metalloenzyme inhibitor; Metalloprotease inhibitor;
KW Protease inhibitor; Secreted; Signal.
FT SIGNAL 1..18
FT /evidence="ECO:0000255"
FT PROPEP 19..121
FT /id="PRO_0000019607"
FT CHAIN 122..241
FT /note="Beta-nerve growth factor"
FT /id="PRO_0000019608"
FT CARBOHYD 69
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 114
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 166
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 136..201
FT /evidence="ECO:0000250|UniProtKB:P01138"
FT DISULFID 179..229
FT /evidence="ECO:0000250|UniProtKB:P01138"
FT DISULFID 189..231
FT /evidence="ECO:0000250|UniProtKB:P01138"
SQ SEQUENCE 241 AA; 27036 MW; 8BFBB207A1FFB2F7 CRC64;
MSMLFYTLIT ALLIGVQAEP YTDSNLPEGD SVPEAHWTKL QHSLDTALRR ARSAPAAPIA
ARVTGQTRNI TVDPRLFKKR KLRSPRVLFS TQPPPTSSDT LDLDFQAHGT ISFNRTHRSK
RSSTHPVFQM GEFSVCDSVS VWVGDKTTAT DIKGNEVTVL GEVNINNSVF KQYFFETKCR
ARNPVESGCR GIDSKHWNSY CTTTHTFVKA LTTDDRQAAW RFIRIDTACV CVLTRKAPRR
G
