ID   NGF_PONPY               Reviewed;         241 AA.
AC   Q9N2E9; Q8HZH1;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 73.
DE   RecName: Full=Beta-nerve growth factor;
DE            Short=Beta-NGF;
DE   Flags: Precursor;
GN   Name=NGF; Synonyms=NGFB;
OS   Pongo pygmaeus (Bornean orangutan).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Pongo.
OX   NCBI_TaxID=9600;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC   STRAIN=Isolate Oran-U1;
RX   PubMed=15014171; DOI=10.1093/molbev/msh100;
RA   Kitano T., Liu Y.-H., Ueda S., Saitou N.;
RT   "Human-specific amino acid changes found in 103 protein-coding genes.";
RL   Mol. Biol. Evol. 21:936-944(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 15-224.
RA   O'Huigin C., Tichy H., Klein J.;
RT   "Molecular evolution in higher primates; gene specific and organism
RT   specific characteristics.";
RL   Submitted (MAR-2002) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Nerve growth factor is important for the development and
CC       maintenance of the sympathetic and sensory nervous systems.
CC       Extracellular ligand for the NTRK1 and NGFR receptors, activates
CC       cellular signaling cascades through those receptor tyrosine kinase to
CC       regulate neuronal proliferation, differentiation and survival. Inhibits
CC       metalloproteinase dependent proteolysis of platelet glycoprotein VI.
CC       {ECO:0000250|UniProtKB:P01138}.
CC   -!- SUBUNIT: Homodimer. Interacts with ADAM10 in a divalent cation-
CC       dependent manner. {ECO:0000250|UniProtKB:P01138}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; AB037520; BAA90440.1; -; Genomic_DNA.
DR   EMBL; AY091927; AAM76545.1; -; Genomic_DNA.
DR   AlphaFoldDB; Q9N2E9; -.
DR   SMR; Q9N2E9; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; ISS:UniProtKB.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR020425; Nerve_growth_factor_bsu.
DR   InterPro; IPR020437; Nerve_growth_factor_bsu_mml.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01925; MAMLNGFBETA.
DR   PRINTS; PR00268; NGF.
DR   PRINTS; PR01913; NGFBETA.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Metalloenzyme inhibitor; Metalloprotease inhibitor;
KW   Protease inhibitor; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..121
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000277874"
FT   CHAIN           122..241
FT                   /note="Beta-nerve growth factor"
FT                   /id="PRO_0000277875"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        166
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        136..201
FT                   /evidence="ECO:0000250|UniProtKB:P01138"
FT   DISULFID        179..229
FT                   /evidence="ECO:0000250|UniProtKB:P01138"
FT   DISULFID        189..231
FT                   /evidence="ECO:0000250|UniProtKB:P01138"
SQ   SEQUENCE   241 AA;  26877 MW;  DFC168E7E4E01F15 CRC64;
     MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR ARSTPAAAIA
     ARVAGQTCNI TVDPRLFKKR RLRSPRVLFS TQPPPEAADT QDLDFEVGGA APFNRTHRSK
     RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT DIKGKEVMVL GEVNINNSVF KQYFFETKCR
     DPNPVDSGCR GIDSKHWNSY CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKAVRR
     A