ID   NGF_SAIBB               Reviewed;         241 AA.
AC   Q5ISB0;
DT   20-FEB-2007, integrated into UniProtKB/Swiss-Prot.
DT   20-FEB-2007, sequence version 2.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Beta-nerve growth factor;
DE            Short=Beta-NGF;
DE   Flags: Precursor;
GN   Name=NGF; Synonyms=NGFB;
OS   Saimiri boliviensis boliviensis (Bolivian squirrel monkey).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Platyrrhini; Cebidae;
OC   Saimiriinae; Saimiri.
OX   NCBI_TaxID=39432;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Brain;
RX   PubMed=15620360; DOI=10.1016/j.cell.2004.11.040;
RA   Dorus S., Vallender E.J., Evans P.D., Anderson J.R., Gilbert S.L.,
RA   Mahowald M., Wyckoff G.J., Malcom C.M., Lahn B.T.;
RT   "Accelerated evolution of nervous system genes in the origin of Homo
RT   sapiens.";
RL   Cell 119:1027-1040(2004).
CC   -!- FUNCTION: Nerve growth factor is important for the development and
CC       maintenance of the sympathetic and sensory nervous systems.
CC       Extracellular ligand for the NTRK1 and NGFR receptors, activates
CC       cellular signaling cascades through those receptor tyrosine kinase to
CC       regulate neuronal proliferation, differentiation and survival. Inhibits
CC       metalloproteinase dependent proteolysis of platelet glycoprotein VI.
CC       {ECO:0000250|UniProtKB:P01138}.
CC   -!- SUBUNIT: Homodimer. Interacts with ADAM10 in a divalent cation-
CC       dependent manner. {ECO:0000250|UniProtKB:P01138}.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAV74256.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; AY665218; AAV74256.1; ALT_INIT; mRNA.
DR   RefSeq; XP_003933556.1; XM_003933507.2.
DR   RefSeq; XP_010342361.1; XM_010344059.1.
DR   AlphaFoldDB; Q5ISB0; -.
DR   SMR; Q5ISB0; -.
DR   STRING; 39432.ENSSBOP00000026931; -.
DR   GeneID; 101038561; -.
DR   KEGG; sbq:101038561; -.
DR   CTD; 4803; -.
DR   OrthoDB; 1156054at2759; -.
DR   Proteomes; UP000233220; Whole Genome Shotgun Assembly.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   GO; GO:0008191; F:metalloendopeptidase inhibitor activity; ISS:UniProtKB.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR020425; Nerve_growth_factor_bsu.
DR   InterPro; IPR020437; Nerve_growth_factor_bsu_mml.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR01925; MAMLNGFBETA.
DR   PRINTS; PR00268; NGF.
DR   PRINTS; PR01913; NGFBETA.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   2: Evidence at transcript level;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Metalloenzyme inhibitor; Metalloprotease inhibitor;
KW   Protease inhibitor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..121
FT                   /evidence="ECO:0000250"
FT                   /id="PRO_0000277876"
FT   CHAIN           122..241
FT                   /note="Beta-nerve growth factor"
FT                   /id="PRO_0000277877"
FT   CARBOHYD        69
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        114
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        166
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        136..201
FT                   /evidence="ECO:0000250|UniProtKB:P01138"
FT   DISULFID        179..229
FT                   /evidence="ECO:0000250|UniProtKB:P01138"
FT   DISULFID        189..231
FT                   /evidence="ECO:0000250|UniProtKB:P01138"
SQ   SEQUENCE   241 AA;  26838 MW;  04AAA100D8E6361E CRC64;
     MSMLFYTLIT AFLIGIQAEP HSESNVPAGH TIPQAHWTKL QHSLDTALRR ARSAPAGPIA
     ARVAGQTRNI TVDPKLFKKR RLRSPRVLFS TQPPPEAADT QDLDFEVAGA APVNRTHRSK
     RSSSHPIFHR GEFSVCDSVS VWVGDKTTAT DIKGKEVMVL GEVNINNSVF KQYFFETKCR
     DPNPVDSGCR GIDSKHWNSY CTTTHTFVKA LTMDGKQAAW RFIRIDTACV CVLSRKASRR
     A