ID   NGF_XENLA               Reviewed;         231 AA.
AC   P21617;
DT   01-MAY-1991, integrated into UniProtKB/Swiss-Prot.
DT   15-DEC-1998, sequence version 2.
DT   03-AUG-2022, entry version 96.
DE   RecName: Full=Nerve growth factor;
DE            Short=NGF;
DE   Flags: Precursor;
GN   Name=ngf; Synonyms=ngfb;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1888511; DOI=10.1002/mrd.1080290402;
RA   Carriero F., Campioni M., Cardinali B., Pierandrei-Amaldi P.;
RT   "Structure and expression of the nerve growth factor gene in Xenopus
RT   oocytes and embryos.";
RL   Mol. Reprod. Dev. 29:313-322(1991).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 170-211.
RC   TISSUE=Liver;
RX   PubMed=2025430; DOI=10.1016/0896-6273(91)90180-8;
RA   Hallboeoek F., Ibanez C.F., Persson H.;
RT   "Evolutionary studies of the nerve growth factor family reveal a novel
RT   member abundantly expressed in Xenopus ovary.";
RL   Neuron 6:845-858(1991).
CC   -!- FUNCTION: Nerve growth factor is important for the development and
CC       maintenance of the sympathetic and sensory nervous systems. It
CC       stimulates division and differentiation of sympathetic and embryonic
CC       sensory neurons.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=CAA39249.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR   EMBL; X55716; CAA39249.1; ALT_INIT; Genomic_DNA.
DR   PIR; S14481; S14481.
DR   RefSeq; XP_018104654.1; XM_018249165.1.
DR   AlphaFoldDB; P21617; -.
DR   SMR; P21617; -.
DR   GeneID; 108709389; -.
DR   KEGG; xla:108709389; -.
DR   CTD; 108709389; -.
DR   Xenbase; XB-GENE-6500082; ngf.S.
DR   OMA; PLNRTHR; -.
DR   Proteomes; UP000186698; Chromosome 2S.
DR   Bgee; 108709389; Expressed in egg cell and 16 other tissues.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR020425; Nerve_growth_factor_bsu.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR00268; NGF.
DR   PRINTS; PR01913; NGFBETA.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Glycoprotein;
KW   Growth factor; Reference proteome; Secreted; Signal.
FT   SIGNAL          1..18
FT                   /evidence="ECO:0000255"
FT   PROPEP          19..114
FT                   /evidence="ECO:0000255"
FT                   /id="PRO_0000019619"
FT   CHAIN           115..231
FT                   /note="Nerve growth factor"
FT                   /id="PRO_0000019620"
FT   REGION          24..53
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        32..49
FT                   /note="Basic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CARBOHYD        63
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        107
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        158
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   DISULFID        128..193
FT                   /evidence="ECO:0000250"
FT   DISULFID        171..221
FT                   /evidence="ECO:0000250"
FT   DISULFID        181..223
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   231 AA;  26416 MW;  72A04E7D00B858C5 CRC64;
     MSMLYYTLLI AILISVQAAP KTKDHAPARS SAKSRIPHHT HRTKSLHHSH GKLEAKEPSY
     FRNVTVDPKL FRKRKFRSPR VLFSTQPPPL SEDFQHLEYL DDEESLNKTI RAKRTVHPVL
     HKGEYSVCDS VSMWVGEKTK ATDIKGKEVT VLGEVNINNS VFKQYFFETK CRDPKPVSSG
     CRGIDAKHWN SYCTTTHTFV KALTMEGKQA AWRFIRIDTA CVCVLSRKGR T