ID   NGF_XIPMA               Reviewed;         194 AA.
AC   P34129;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 97.
DE   RecName: Full=Nerve growth factor;
DE            Short=NGF;
DE   Flags: Precursor;
GN   Name=ngf; Synonyms=ngfb;
OS   Xiphophorus maculatus (Southern platyfish) (Platypoecilus maculatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Atherinomorphae; Cyprinodontiformes; Poeciliidae; Poeciliinae;
OC   Xiphophorus.
OX   NCBI_TaxID=8083;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX   PubMed=1629719; DOI=10.1111/j.1471-4159.1992.tb09389.x;
RA   Gotz R., Raulf F., Schartl M.;
RT   "Brain-derived neurotrophic factor is more highly conserved in structure
RT   and function than nerve growth factor during vertebrate evolution.";
RL   J. Neurochem. 59:432-442(1992).
CC   -!- FUNCTION: Nerve growth factor is important for the development and
CC       maintenance of the sympathetic and sensory nervous systems. It
CC       stimulates division and differentiation of sympathetic and embryonic
CC       sensory neurons as well as basal forebrain cholinergic neurons in the
CC       brain.
CC   -!- SUBUNIT: Homodimer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- SIMILARITY: Belongs to the NGF-beta family. {ECO:0000305}.
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DR   EMBL; X59941; CAA42566.1; -; Genomic_DNA.
DR   PIR; I51709; I51709.
DR   RefSeq; XP_005813808.1; XM_005813751.1.
DR   AlphaFoldDB; P34129; -.
DR   SMR; P34129; -.
DR   STRING; 8083.ENSXMAP00000020404; -.
DR   Ensembl; ENSXMAT00000020432; ENSXMAP00000020404; ENSXMAG00000020357.
DR   eggNOG; ENOG502RYPU; Eukaryota.
DR   GeneTree; ENSGT00390000007725; -.
DR   HOGENOM; CLU_059942_2_0_1; -.
DR   InParanoid; P34129; -.
DR   OMA; PLNRTHR; -.
DR   OrthoDB; 1156054at2759; -.
DR   Proteomes; UP000002852; Unassembled WGS sequence.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR   Gene3D; 2.10.90.10; -; 1.
DR   InterPro; IPR029034; Cystine-knot_cytokine.
DR   InterPro; IPR020408; Nerve_growth_factor-like.
DR   InterPro; IPR002072; Nerve_growth_factor-rel.
DR   InterPro; IPR019846; Nerve_growth_factor_CS.
DR   PANTHER; PTHR11589; PTHR11589; 1.
DR   Pfam; PF00243; NGF; 1.
DR   PIRSF; PIRSF001789; NGF; 1.
DR   PRINTS; PR00268; NGF.
DR   SMART; SM00140; NGF; 1.
DR   SUPFAM; SSF57501; SSF57501; 1.
DR   PROSITE; PS00248; NGF_1; 1.
DR   PROSITE; PS50270; NGF_2; 1.
PE   3: Inferred from homology;
KW   Cleavage on pair of basic residues; Disulfide bond; Growth factor;
KW   Reference proteome; Secreted; Signal.
FT   SIGNAL          1..30
FT                   /evidence="ECO:0000255"
FT   PROPEP          31..79
FT                   /id="PRO_0000019621"
FT   CHAIN           80..194
FT                   /note="Nerve growth factor"
FT                   /id="PRO_0000019622"
FT   REGION          56..81
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        90..155
FT                   /evidence="ECO:0000250"
FT   DISULFID        133..183
FT                   /evidence="ECO:0000250"
FT   DISULFID        143..185
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   194 AA;  21596 MW;  0369E0F4A51147AE CRC64;
     MRSSMLVLFL IFSAQAVAPI IGVLCSVTTA QQDHPTSIPT VDPKLFNKRR HLSPRVLFSS
     QPPDAEPAGG QGVSRRTRRQ PQHRGVYSVC ESVSVWVGNK TKATDISGKE VTVLPYVNIN
     NVKKKQYFFE TTCHSPPSGG SRCLGIDARH WNSHCTNSHT FVRALTSSEN QVAWRLIRIN
     VACVCVLSRK SWQH